Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"PkB"”.
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PKB/Akt : a critical regulator of lymphocyte, development and function
Protein kinase B (PKB), a serine threonine kinase, is highly involved in the regulation of cellular proliferation and survival. To characterize PKB’s function in lymphocyte development and activation, transgenic (tg) mice that express a membrane targeted constitutively active form of PKBa (myr PKB) …
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Identificazione delle Lamine di tipo A come nuovi substrati della protein chinasi Akt/PKB
Akt (also called PKB) is a 63 kDa serine/threonine kinase involved in promotion of cell survival, proliferation a nd metabolic responses downstream the phosphoinositide-3-kinase (PI 3-kinase) signaling pathway. In resting cells, Akt is a predominantly cytosolic enzyme; however generation of PI …
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Investigating the role of ACSS2-mediated acetyl-CoA metabolism on EGFR-PI3K-PKB signalling
… (PI3K)-protein kinase B (PKB) pathway. This pathway is not only essential for cellular function, but has also been commonly implicated in the diseased state, including cancer and immunological deficiencies, therefore understanding its regulation is fundamental in revealing …
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Modulation of the NFAT signaling pathway by protein kinase B (PKB) ; a perspective study in the context of thymocyte development and T cell function
To analyze the role of protein kinase B(PKB)on developmental and functional aspects of T cells, we have generated transgenic mouse lines expressing a constitutively active form of PKB (myrPKB) in early stages of T cell development.Peripheral CD4+ T cells from PKB tg mice are hyperreactive, more …
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Mecanismos implicados en la protección de la apoptosis neuronal en células granulares de cerebelo por lítio valproato
… estudiando las vías de supervivencia PI3K/PKB y ERK observamos tambien su inactivación, por desfosforilación de las quinasas de dichas vias. A su vez se ha observado que el medio proapoptótico induce la activación de la actividad serina/treonina fosfatasa de tipo 2A, 2B y 2C. El Litio …
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PREPARATION AND EVALUATION OF DECONSTRUCTION ANALOGS OF 7-DEOXYKALAFUNGIN AS AKT INHIBITORS
… inhibitors of the serine-threonine kinase AKT/PKB. AKT/PKB plays a major role in tumorigenesis, hence these compounds have a great potential to act as anti-cancer agents. They act by a novel bioreductive alkylation mechanism of inhibition of AKT/PKB. In this work, 7-deoxykalafungin, a …
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The Role of the Mammalian Target of Rapamycin (mTOR) in Cytotoxic T Lymphocytes
… feedback control of the serine/threonine kinase PKB. This prompted detailed analysis of the role of mTOR in the regulation of the phosphatidylinositol (3,4,5)-trisphosphate (PIP3) signalling effector PKB in CTL. A striking observation was that mTOR inhibitors allow T cells to accumulate very high …
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The cardioprotective mechanisms of dietary flavonoids
… the effect of quercetin pre-treatment on ERK1/2, PKB, JNK and p38 MAPK phosphorylation was monitored using western blotting. It was shown that quercetin was the most potent flavonoid at inducing a protective effect, and 3’-O-methylquercetin the most potent metabolite. Using western blotting it was …
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Der Transkriptionsfaktor FKHR interagiert mit STAT-Faktoren und verstärkt die IL-6-Signaltransduktion
… activation of PI3 kinase and the ProteinkinaseB (PkB). Within the cell the IL6 signal is mediated via Janus kinases and STAT factors. This results in production and secretion of acute phase proteins in hepatocytes. For the first time it was possible to identify the transcription factor FKHR as a …
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Die Regulation aktivierender und hemmender Signalwege in humanen neutrophilen Granulozyten durch cAMP- und cGMP-erhöhende Vasodilatatoren
… der p42/p44-, p38-MAPK sowie auch der PKB. Diese intrazellulären Signalmoleküle spielen eine zentrale Rolle bei der Neutrophilenaktivierung. Da es bereits von hemmenden Einflussen der Vasodilatatoren auf die Aktivierung der Neutrophilen Granulozyten berichtet worden ist, wurde in der …
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Excited state proton transfer in 2-substituted benzothiazoles
… with Forster cycle calculations to yield pKa, pKb, pKa* and pKb* values for the various compounds. The results have been compared with those for the corresponding phenols and many similarities noted. The overlap of the pK a* and pKb* values for HBT and derivatives has been noted. This has …
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Rutas de señalización intracelular que regulan la apoptosis inducida por lovastatina en neuroblastos fetales de rata
… pathways Duch as RAS/RAF/MAP-kinases, PI3-K/PKB, as well as death pathways, stress-activated MAP-kinases (JUN-kinases and p38).
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Characterisation of the role of AMP-activated protein kinase in 3T3-L1 adipocytes
… as potential targets of both protein kinase B (PKB, also known as Akt) and AMPK which mediate glucose transporter 4 (GLUT4) translocation to the plasma membrane in response to insulin and 5-aminoimidazole-4-carboxamide riboside (AICAR) respectively in muscle. Previous work in our laboratory has …
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Protein kinases in hormonal regulation of adipocyte metabolism.
… exerts it actions through protein kinase B (PKB). Although PKB is known to mediate many effects of insulin, its role in lipogenesis in adipocytes is less clear. We show that PKB is important for the effects of insulin on lipogenesis (de novo and total). We also reveal that PKB can regulate …
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Fourth Belgrade : story about reclaiming land
… of one-directional progress. In August of 2018, PKB- a publicly owned cattle and crop production corporation and one of the main food producers in Serbia since 1945, was put on tender. The firm and its 300 sq km big land just north of Belgrade was to be traded for fifty percent of its estimated …
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Novel Insights Into Normal Aryl Hydrocarbon Receptor Biology Through the Regulation of Stanniocalcin 2
… AhR promotes cell survival through the PI3K-Akt/PKB axis in the absence of an exogenous ligand. However this study was performed using a cancer cell line that does not accurately represent normal liver biology. Therefore, I hypothesize that the AhR mechanistically contributes to liver homeostasis …
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Car-Parrinello Moleküldynamik-Simulationen zur Hydratisierung und Protonierung von Aminen
… und der molekülspezifischen pKB-Werte beantwortet werden. Des Weiteren lässt die Arbeit Aussagen über einen Zusammenhang von Hydratation und anormaler Basiszitätsreihenfolge der Amine zu und ermöglicht zusätzlich die Beschreibung von Systemen mit mehreren Aminfunktionen durch …
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Dual regulation of transcription factor Nrf2 by Keap1 and the beta-TrCP/GSK-3 in cancer
… 3- kinase- protein kinase B (PI3K-Akt/PKB) signalling pathway. The ability of tert-butylhydroquinone (tBHQ), 1-[2-cyano-3,12-dioxooleana-1,9(11)-diene-28-oyl]imidazole (CDDO-Im), diethyl maleate (DEM), curcumin, carnosol, ferulic acid and sulforaphane (SFN) to activate Nrf2-target genes …
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Reaktion des Epstein-Barr-Virus und seiner Wirtszelle B95-8 auf die Überexpression der extrazellulär-regulierten Kinase 3 (p97)
… coding for 14-3-3zeta/PLA2, protein kinase B (PKB) and s-adenosylhomocystic hydrolase (SAH) induced a significant ERK3 (p97) overexpression in B95-8 cells.Previous experiments had shown viral reactivation in response to overexpression of the gene products mentioned above. Thus, a role for ERK3 …
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Insulin and TSH signal transduction pathways in human preadipocytes.
… human preadipocytes, and have shown it activates PKB and p70 S6K in a wortmannin-sensitive manner. A model depicting the convergence of insulin and TSH signaling in human preadipocytes is proposed.
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