Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Pituitary development"”.
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Defining critical windows in pituitary development and elucidating sex differences in response to bisphenoL A
Open Restriction set for Item 102628 on 2019-06-12T18:33:51Z with date null by mhoh2@illinois.edu.
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The role of notch signaling in the regulation of proliferation and cell differentiation during embryonic and postnatal pituitary development
The pituitary develops in two distinct waves in mice, one occurring during embryogenesis and a second taking place during early postnatal development. During both periods, progenitor cells proliferate and subsequently differentiate into hormone-producing cells. Maintaining the proper number of …
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DELETION OF THE Foxo1 GENE IN MOUSE PITUITARY GLAND AND THE EFFECTS ON SOMATOTROPE DIFFERENTIATION AND FUNCTION
… transcription factors that are necessary for pituitary development. Lesions in the transcription factor genes result in pituitary hormone deficiency. Hormone deficiencies occur in approximately one in 4000 live births. Pituitary hormone deficiency may occur due to loss of a single hormone …
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Uncovering molecular mechanisms of the notch signaling pathway in the regulation of pituitary gland development
The pituitary acts as a central mediator of the endocrine system, integrating both hypothalamic and peripheral signals to coordinate physiological functions through the release of hormones from distinct endocrine cell types within the gland. During development, the endocrine cell types are derived …
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Sampling Strategies for Characterization of Neuropeptides Using Mass Spectrometry and Functional Implications Into Cell -Cell Signaling
The peptides with roles in the development of the pituitary were analyzed using transgenic mice. Hes1 KO is a genetically modified mouse that lives only e18.5 (embryonic days). Anterior pituitaries of Hes1 null mice exhibit hypoplasia due to increased cell death and reduced proliferation and in the …
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The role of notch signaling in the development of the hypothalamic-pituitary axis and arcuate nucleus
Development of the hypothalamic-pituitary axis requires precise neuronal signaling to establish a network that regulates neuroendocrine homeostasis. The anterior lobe (AL) and intermediate lobe (IL) of the pituitary are formed from the primordial structure Rathke’s pouch, while the posterior lobe …
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Discovering the Effects of Intrinsic and Extrinsic Signals on the Developing Pituitary Gland
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-04-12 without embargo terms
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Sonic hedgehog signaling pathway in normal and adenomatous pituitary
… of Sonic hedgehog signaling pathway in adult pituitary and in pituitary tumors. Shh is a signaling protein, important in regulating patterning and proliferation in the embryo and the adult. It has a crucial role in pituitary development and Shh deficient mice do not even have a rudimentary …
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Uncovering novel actions of numb and aryl hydrocarbon receptor in the pituitary
Many physiological responses are regulated by the pituitary including, but not limited to, growth, metabolism, response to stress, and fertility. These responses in the anterior lobe are mediated by the release of the following hormones, growth hormone (GH), adrenocorticotropic hormone (ACTH), …
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Sampling strategies for characterization of neuropeptides using mass spectrometry and functional implications into cell-cell signaling
… peptides. The peptides with roles in the development of the pituitary were analyzed using transgenic mice. Hes1 KO is a genetically modified mouse that lives only e18.5 (embryonic days). Anterior pituitaries of Hes1 null mice exhibit hypoplasia due to increased cell death and reduced …