Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 2 of 2 for “"Pironetin"”.
-
Asymmetrische Synthese von Tarchonanthuslacton und Pironetin-Bausteinen
The natural product Pironetin was isolated from the culture broths Streptomyces sp. NK10958 and Streptomyces prunicolor PA-48153 in 1994 and shows remarkably high antitumor and immunosuppressive activity. Aim of this thesis was an efficient asymmetric synthesis of the aforementioned natural …
-
NOVEL MICROTUBULE TARGETING AGENTS: SYNTHESIS AND STRUCTURAL DETERMINATION OF THEIR INTERACTIONS
… 2.3, the synthesis of simplified biotinylated pironetin analogues is described. Pironetin, a natural product that covalently binds alfa-tubulin, and the possibility of its biotinylation to use then biotin capturing on streptavidin for protein immobilization. Taking into consideration the low …