Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Pips"”.
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Computational prediction of human protein-protein interactions
… our group developed PIPs, a predictor of protein-protein interactions in human based on a naive Bayesian framework that has undergone two version releases (Scott et al., 2007, McDowall, 2011). In this thesis, a third version of PIPs, PIPs v. 3.0, is described. In …
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Direct Reprogramming of Fibroblasts into Smooth Muscle Cells
… defined as partially induced pluripotent stem (PiPS) cells. PiPS cells did not form tumours in vivo and differentiated into smooth muscle cells (SMCs) when seeded on a Collagen IV substrate and maintained in differentiation media (DM). The PiPS-SMCs expressed a panel of SMC markers such as SMA, …
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Comparative Efficacy of MUS System vs Er:YAG Laser System in Reducing Bacterial Biofilms in Root Canals
… Photon Induced Photo-acoustic Streaming (PIPS) and Shock Wave Enhanced Emission Photoacoustic Streaming (SWEEPS). To conduct this evaluation, forty extracted human mandibular molars meeting the inclusion criteria were collected, processed, and sterilized following Institutional Review …
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Investigation of Phosphatidylinositols and Phosphoinositides Using Matrix- Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
… their phosphorylated forms, phosphoinositides (PIPs), which are critical regulators of cellular signaling, membrane dynamics, and cytoskeletal organization. Dysregulation of PIs and PIPs are implicated in various diseases, including atypical hemolytic uremic syndrome (aHUS), necessitating a …
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Human protein-protein interaction prediction
… the framework of the previously established PIPs protein-protein interaction predictor Scott and Barton 2007. New features considered include the semantic similarity of Gene Ontology annotating terms, clustering of interaction networks, primary sequences and gene co-expression. Integrating …
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Microbiological Study of Bacterial Load Reduction in the Root Canal System Utilizing a Novel ErYagLaser
… (SNI), Photon-Induced Photoacoustic Streaming (PIPS) – single pulse laser mode, Shock Wave Enhanced Emission Photo-acoustic Streaming (SWEEPS) – double pulse laser mode, and a baseline control. The study found no significant differences in bacterial load reduction between the different …
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Integrated Photonic Iterative Processors for Computing
… per data I/O. Photonic iterative processors (PIPs) with optical loopback for matrix inversion and related applications happen to be one of such examples towards a more practical optical processor. By enabling direct loopback in the optical domain across different iterations, PIPs significantly …
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Structural basis of membrane targeting and regulation of the innate immunity adaptor TIRAP by its phosphoinositide-binding motif
… mimics. NMR studies reveal that TIRAP PBM binds PIPs following a fast exchange regime with a moderate affinity through two conserved basic termini. Mutation of these two basic regions abolishes PIPs binding without distorting the helical structure of the peptide. Solution NMR structure of TIRAP …
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Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
… (phosphatidylinositol phosphates or PIPs), an important class of regulatory phospholipids. PH domains are presumed to bind PIPs, but specific interaction with and regulation by PIPs for most PH domain-containing protein remains unclear. Recapitulating biologically relevant …
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Molecular mechanisms of Sorting nexin-9 in membrane triggered actin polymerisation
… actions with phosphatidylinositol phosphates (PIPs) at membranes, and membrane curvature sensing to trigger actin polymerisation via the Arp2/3 complex. While membrane binding is key in in vitro purified reconstitutions of actin polymerisation, the lipid specificity and contribution of each …
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Thermally/Mechanically Responsive Polymeric Composites with Shape Memory/Self-Healing Properties
… and polymerization induced phase separation (PIPS) of an epoxy matrix with and without a semicrystalline thermoplastic was investigated. Same PIPS technique studied in this chapter was utilized in the following chapters to develop composites featuring triple shape memory and self-healing …
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Identification and characterization of phosphoinositide-binding Legionella effector proteins
… to recognize and bind host phosphoinositides (PIPs) (Steiner, Weber, & Hilbi, 2018), which are a series of phospholipids that play critical roles in coordinating cell signaling and membrane trafficking events in eukaryotic cells (Di Paolo & De Camilli, 2006). L. pneumophila effector proteins …
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GPCR to Channel Communication in a Membrane Signaling Pathway
… of Kir2.2 to different phosphoinositides (PIPs). I show that 5' phosphate is essential to Kir2.2 gating. Other PIPs without 5' phosphate can compete with PI(4,5)P<sub>2</sub> but cannot activate Kir2.2. A cell typically has multiple signaling pathways operating simultaneously, often even …
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A mixed-methods study of the impact of simulation-based education on the general practice clinical pharmacist in NHS Scotland.
… patient-facing roles as independent prescribers (PIPs). It was evident that pharmacists qualified as PIPs were not making full use of their qualifications in clinical practice. Research has shown that pharmacists would benefit from more problem-solving, critical thinking and communication skills …
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Modeling insect resistance to transgenic corn and cowpea
… and Bt corn plant-incorporated protectants (PIPs) since the late 1990s. For my dissertation research, I built four species-specific, simulation models to study the evolution of resistance by four insect pests of corn or cowpea to transgenic crops to 1) forecast the durability of traits in …
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The economy of the Roman south Pennines with particular reference to the lead extraction industry in its national context.
… the specific example under study.All the extant pips are listed in a detailed catalogue (Appendix 1) and some further implications of their study are considered in Appendices 2 and 3.Ancient and modern comparative evidence is also cited for the lead industry and a model for its nature is …
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Data-driven models of water and methane
… approximation using the model based on PIPs. As the fitted level, CCSD(T)-F12, is not applicable to larger systems, we compare the calculations to DMC results for the larger clusters and periodic systems. However, small systematic differences are found between the developed models and …
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Gripped end effect in tensile proof testing dimension lumber
… if the pieces were only 10 feet long. Then the pips of the testing machine were moved out so that the entire middle 10-foot, section including the portions that had been gripped during the initial proof test would be fully stressed during a second tension test Some specimens, referred to as …
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Structural basis for interactions of the Phytophthora sojae RxLR effector Avh5 with phosphatidylinositol 3-phosphate and for host cell entry
… motifs in the effectors and phosphoinositides (PIPs) resident in the host plasma membrane such as phosphatidylinositol 3-phosphate (PtdIns(3)P). Recent reports differ regarding the regions on RxLR effector proteins involved in PIP recognition. To clarify these differences, I have structurally …
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Targeting Ph Domain Proteins For Cancer Therapy
… domain proteins are unknown due to lacking of PH-PIPs complex crystal structures. Second, these binding pockets are positively charged, which makes it really difficult to design small molecule inhibitors targeting these sites. In order to address these issues, we performed structural sequence …
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