Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Piperaquine"”.
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Piperaquine - Bioanalys, drug metabolism and pharmacokinetics
… episodes each year with up to 3 million deaths. Piperaquine replaced chloroquine as the first line treatment in China for Plasmodium falciparum malaria in the 1970s and was used as mass prophylaxis until the emergence of resistance in the 1990s. It has recently been the object of renewed interest …
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An investigation of the mechanisms of piperaquine resistance in Plasmodium falciparum malaria
… and one of the widely used partner drugs, piperaquine, have been reported in multiple locations in SEA. It is therefore necessary to have reliable methods for detecting and evaluating resistant phenotypes. The purpose of this study was to combine clinical data from Cambodia with findings …
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Effect of dihydroartemisin-piperaquine for malaria intermittent preventive treatment on dolutegravir exposure in pregnant women living with HIV
… preventive treatment (IPTp). Dihydroartemisinin-piperaquine has been identified as a promising alternative to sulfadoxine-pyrimethamine for malaria prevention in pregnancy. However, another antimalarial drug, artesunate-amodiaquine, similar to dihydroartemisininpiperaquine, was previously shown …
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Changing Antimalarial Drug Sensitivities in Uganda
<p>Dihydroartemisinin-piperaquine (DP) has demonstrated excellent efficacy for the treatment and prevention of malaria in Uganda. However, resistance to both components of this regimen has emerged in Southeast Asia. The efficacy of artemether-lumefantrine, the first-line regimen to treat malaria in …
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The influence of genetic background on drug resistance in the malaria parasite Plasmodium falciparum
… spreading in Southeast Asia that confers piperaquine resistance when edited into the wild-type *pfcrt* allele of laboratory lines using CRISPR/Cas9, raising concerns that piperaquine resistance could arise in susceptible populations with a single nucleotide polymorphism. Finally, I …
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Anti-malaria drug treatment in Vietnam
… is<br></br><br></br> 1/ Dihydroartemisinin-piperaquine is an inexpensive, safe, highly efficacious fixeddose antimalarial combination treatment that could make an important contribution to the control of multidrug-resistant fa1ciparum malaria for Vietnan1 and other …
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Comparative and Epidemiological Genomics of Human Malaria Parasites
… drugs, including chloroquine, artemisinin and piperaquine, I identify a specific haplotype of the pfcrt gene that displays super-resistance to chloroquine and that acts as a genetic backbone to artemisinin resistance and to multidrug resistance in general. The approach taken in this thesis is …
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Probing the chemical biology involved in the haem detoxification pathway of the human malaria parasite, plasmodium falciparum
… like chloroquine (CQ), amodiaquine (AQ) and piperaquine (PPQ) target this process, the pathway has received tremendous recognition within the drug discovery and development arena as a valuable, druggable target. However, the pathway involves multiple processes that are equally important and …