Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Pioglitazone"”.
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Pharmacokinetics and effect of pioglitazone in obese, insulin-resistant cats
Pioglitazone is a thiazolidinedione (TZD) insulin sensitizer approved for use in human type 2 diabetes mellitus. In addition to improving glycemic control, lipid profiles, and pancreatic β-cell function in diabetics, pioglitazone decreases hepatic triglyceride content in humans with non-alcoholic …
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A pharmacokinetic and pharmacodynamic study of pioglitazone in a model of induced insulin resistance in normal horses
… the incidence of laminitis in horses with EMS. Pioglitazone, a thiazolidinedione class of anti-diabetic drug, has proven efficacy in humans with type 2 diabetes, a syndrome of insulin resistance sharing some similarities with EMS. The ability of pioglitazone to influence insulin sensitivity in …
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Anticonvulsant effects of PPAR-gamma activation in an in vitro model of seizure
… experiments with a PPARγ agonist (pioglitazone) and an antagonist (GW 9662) to test their efficacy in an in vitro model of seizure using high potassium. We observed that pioglitazone delayed the latency to seizure-like events (SLE) onset and decreased the intraSLE frequency by …
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Assessment and Treatment of Impaired Insulin- Secretion and Action in Type 2 Diabetes
… I). We also evaluated the effect of a TZD (pioglitazone) and a long-acting insulin (glargine) as add-on in the treatment of patients with T2D, not achieving glycaemic goals when treated with classic anti-diabetic agents on glycaemic control, insulin sensitivity, β-cell function and markers …
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Mechanisms of Regulation of Proximal Tubule Sodium Transporters in Obesity-Induced Hypertension
… tubule epithelial cells, we determined whether pioglitazone exerts its effect via direct PPARγ activation. Pioglitazone reduced systolic blood pressure in obese rats while having no effect in lean rats. However, it increased sodium retention in the lean group. Pioglitazone increased Na,K-ATPase …
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Regulation of Nutrient Metabolism in Equine Skeletal Muscle and Adipose Tissue
… the influence of the insulin-sensitizing drug, pioglitazone, and lipopolysaccharide, on nutrient metabolism in skeletal muscle and adipose tissue, and their association with insulin sensitivity. Pioglitazone treatment did not increase insulin sensitivity; however it did increase skeletal muscle …
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Pharmacokinetics and Biological Mechanisms of Drug Outcomes in Type 2 Diabetes Mellitus
… tests to assess their response to metformin and pioglitazone. Although unable to validate the GWAS result, the study data show that pioglitazone improves the insulin resistance and adipocyte dysfunction associated with A-T, and suggests that pioglitazone, rather than metformin, should be …
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Identifying novel therapeutic targets for seizures and brain cancers
… to investigate the role of the PPARγ agonist pioglitazone on glutamate transport in vitro. Pioglitazone was chosen for its established safety profile in type 2 diabetes and widely reported anti-neoplastic effects. I demonstrated that pioglitazone increases EAAT2 expression and reduces …
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Development of Therapies to Treat Polycystic Kidney Disease
… studied showed that high (20 mg/kg BW) dose pioglitazone, a PPARγ agonist, inhibited cyst growth in the PCK rat model, a slow progressing model, of PKD. To continue to look at the effects of the PPARγ agonists another preclinical study was completed, which tested if there was a class action …
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A study of the protective effects of an aspalathin enriched green rooibos extract on experimentally induced hepatic steatosis
… exposed to oleic acid were included as controls. Pioglitazone was used as a positive control. Steatosis of C3A cells was induced using 1 mM oleic acid for 24 hours. Treatment with GRT and pioglitazone for 24 hours, either commenced in the presence of oleic acid (simultaneous treated group) or 24 …
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Improvement of Gastroparesis Management By Addressing Challenges in Drug Metabolism: Studies with Metabolite Identification, Reaction Phenotyping and In Vitro Drug-Drug Interactions
… pathways. Domperidone in combination with pioglitazone and ondansetron was evaluated. Results showed that pioglitazone inhibited domperidone metabolism in-vitro. Our experiments did not predict a DDI for the domperidone - ondansetron combination. In summary, the ultimate goal of this thesis …
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Spray Techniques And Lung Cancer Chemoprevention
… Polyphenon E, diet indole-3-carbinal, or oral pioglitazone in the animal study for the inhibitory effects over lung carcinogenesis. Aerosol characterization and drug concentration in different organs of mice, after exposure to the drug aerosols, were also carried out to facilitate the data …
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Market Response to Food and Drug Administration's Safety Warnings: a Case Study Using an Interrupted Time Series Analysis of the Medicare Database for 2006-2008
… on the post-intervention utilization rates of pioglitazone. Following the intervention, we observed a general decline in utilization for thiazolidinediones. Conclusions: The initial safety warning about rosiglitazone's cardiovascular safety was effective in decreasing rosiglitazone's …
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Retinoid X Receptor activation reverses age-related deficiencies in myelin debris phagocytosis and CNS remyelination
… The FDA-approved agonists bexarotene and pioglitazone, when used in concentrations achievable in human subjects, caused a reversion of the gene expression profiles in MS patient monocytes to a more youthful profile and enhanced myelin debris phagocytosis by patient cells. Activation of …
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Cardiometabolic aspects of polycystic ovary syndrome
… in women treated with either metformin or pioglitazone. I found that pioglitazone significantly improved endothelial function and hs-CRP whereas metformin did not produce significant improvements. Chapter seven evaluates the effects of orlistat, metformin and pioglitazone on metabolic …
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Biogenesis and Redox Transition of Iron-sulfur Clusters in Proteins
… identified target of the type II diabetes drug pioglitazone. The studies show that mitoNEET [2Fe-2S] clusters can be readily reduced by biological thiols and human glutathione reductase, and is reversibly oxidized by hydrogen peroxide, suggesting that mitoNEET may undergo redox transitions to …
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Investigation of plant derived compounds mediating cell signalling effectson FOXO1a and AMPK
… similar to the T2D drugs metformin and pioglitazone, which both activate AMOK signalling and reduce phosphorylation of the ribosomal protein S6.<br/>The project began with an analysis of plant extracts which can mediate intracellular cell signalling effects on FOXO1a and AMPK. The pilot …
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The signalling pathways allowing hormonal regulation of Na+ transport in murine collecting duct cells
… inhibited both Akt and SGK1 activity. The TZDs pioglitazone and rosiglitazone did not alter basal or insulin-stimulated Na+ transport and had no effect on SGK1 activity indicating these drugs do not alter Na+ absorption in this cell line. Dexamethasone stimulated ENaC-mediated Na+ transport in a …
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Clinical Drug-Gene and Drug-Drug-Gene Interactions for the Most Commonly Used Chronic Drugs in the UK
… and the association of CYP2C8*3 with reduced pioglitazone efficacy. We also report some other novel and potentially important associations from both the DG and DDG interaction studies.<b><br/></b><b><br/></b><b>Conclusion</b>: The work in this thesis highlights the value of using large …
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Mitochondrial dynamics in demyelinated axons in a cerebellar slice culture system
… Increasing mitochondrial biogenesis with pioglitazone increased axonal mitochondrial parameters, as well as ameliorated axonal damage after demyelination with lysolecithin. As the neuronal cell bodies in MS harbour mitochondrial DNA deletions, which affects their physiology, including …
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