Global ETD Search
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Showing 1 to 1 of 1 for “"PiggyBac transposase"”.
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Novel immunotherapy for paediatric cancers
… CART cells. Originally generated CAR19 using piggyBac (PB) transposon system had poor in vivo efficacy and persistence. Here we show that modifications in CAR constructs removing IgG1 Fc and incorporation of CD28 or 4-1BB co-stimulatory domains improve the in vivo potency of PB-CARs. At …