Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Pifithrin"”.
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Protection of Pifithrin-α and Melatonin against Doxorubicin-Induced Cardiotoxicity.
… designed to explore the protective effects of pifithrin-α and melatonin against doxorubicin-induced cardiotoxicity. Doxorubicin was injected at a dose of 22.5 mg/kg (i.p.) in mice to induce cardiotoxic effects. Meanwhile, doxorubicin caused a significant increase of cardiac cell apoptosis …
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Identification of small molecule inhibitors targeting Plasmodium falciparum Hsp70-Hop pathway
… PfHop and PfHsp70-1 by colistin sulfate and pifithrin µ. In order to carry out in vitro assays, both PfHop and PfHsp70-1 were heterologously expressed in E. coli XL1 Blue cells and further purified by nickel affinity chromatography. Using ELISA, it was observed that the inhibition of the …
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Development of high-throughput screening assays to identify small molecule inhibitors of Plasmodium falciparum Hsp70-1
… treatment with inhibitors colistin sulfate and pifithrin μ hindered the growth of cells heterologously expressing DnaK and KPf under non-permissive temperatures by 50-fold. Interestingly, the inhibitors seemed not to have any effect on the cells heterologously expressing the mutant protein …
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The Role of METTL21A in Kras-driven Cancers
… available HSP70 inhibitors and identified that Pifithrin-μ couldinhibit METTL21A-depleted cells compared with the control. We further investigated the sensitivity of METTL21A depletion cells to the <em>Kras<sup>G12C</sup> </em>inhibitor, AMG510, treatment. The results suggest that …
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Sublethal Hepatic Pathology and Evidence of Intranuclear Effects of the Cyanobacterial Toxin Microcystin -Lr
… with normal p53 were given doses of MCLR. Also, pifithrin, a chemical inhibitor of p53, was used to determine if it could prevent MCLR induced hepatocyte apoptosis. In both experiments, p53 did not play an essential role in the induction of apoptosis, indicating that other pathways are involved. …
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Neurological Consequences of Viral Encephalitis: Behavioral Deficits, Neuronal Restructuring, and Therapeutic Interventions
… we investigated the therapeutic potential of Pifithrin-μ (PFT-μ), an inhibitor of the autophagy-associated chaperone HSP70. PFT-μ treatment resulted in a significant reduction in viral replication for VEEV and related alphaviruses. In mice, PFT-μ treatment reduced weight loss, neurological …
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Multiple roles of epithelial signaling during craniofacial and foregut morphogenesis
… of early cell death with the p53 inhibitor pifithrin-α shows that Sonic Hedgehog is necessary for cartilage condensation and differentiation later in development. Without cartilage differentiation the mandible is unable to elongate properly and hypoplasia occurs.</p><p>Caudal to the …
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hCLCA2 IS A p53-REGULATED GENE REQUIRED FOR MESENCHYMAL TO EPITHELIAL TRANSITION IN BREAST
… inhibited by p53 knockdown and by p53 inhibitor pifithrin, indicating that p53 activates the endogenous hCLCA2 promoter in response to DNA damage. An adenovirus encoding hCLCA2 induced a cell cycle lag in G0/G1 phase, decreased intracellular pH from 7.49 to 6.7, caused Bax and Bad translocation …