Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Piezo1"”.
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PIEZO1 Channel-Mediated Mechanotransduction as a Driver of Cardiac Remodelling
… the Ca2+-permeable mechanosensitive ion channel PIEZO1 in cardiac fibroblasts, aiming to determine how PIEZO1-mediated fibroblast mechanotransduction contributes to hypertrophy and fibrosis under pressure overload, and whether pharmacological inhibition of PIEZO1 signalling could offer …
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The Role of Piezo1 in Mediating Chondrocyte Cell Signaling and Senescence
… and inflammation. Mechanosensitive ion channels PIEZO1 and PIEZO2 have been implicated in OA progression via calcium signaling in chondrocytes. This study investigates the role of conditional Piezo channel knockout (cKO) in modulating calcium signaling and senescence in OA, particularly under the …
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Piezo1-dependent mechanical regulation of chemical signalling in the developing Xenopus laevis brain
… knockdown of the mechanosensitive ion channel Piezo1, which transduces mechanical signals into intracellular chemical signals. Piezo1 downregulation led to a decrease in both semaphorin 3A (sema3A) and slit1 expression. Piezo1 depletion not only altered the chemical landscape of the developing …
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Interplay between Piezo1-mediated mechanosensing and the chemical guidance cue Semaphorin3A during development of the embryonic nervous system
… cues is the mechanosensitive ion channel (MSC) Piezo1. Perturbations of Piezo1 resulted in aberrant axon guidance in vivo. When I studied Piezo1 downregulation further, I found that it regulates not only axon pathfinding but also mechanical tissue properties. Tissue-specific downregulation of …
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Ο ρόλος των μηχανοϋποδοχέων στη μη-αλκοολική στεατοηπατίτιδα
… της ηπατικής παθοφυσιολογίας. Μεταξύ αυτών, το Piezo1 έχει συσχετιστεί με φλεγμονώδεις και ινωτικές διεργασίες σε διάφορους ιστούς, ωστόσο ο ρόλος του στη μεταβολική νόσο του ήπατος δεν έχει πλήρως αποσαφηνιστεί. Σκοπός της παρούσας μελέτης ήταν η διερεύνηση της πιθανής εμπλοκής του Piezo1 στην …
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Molecular Basis of Mechanosensitivity
… conductances in mouse embryonic stem cells is Piezo1, a mechanosensitive channel canonically known for displaying fastinactivating kinetics. With very few modulators known to date, the mechanism by which Piezo1 could produce slow inactivating currents was not known. To address possible novel …
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Substrate stiffness tunes the neuronal response to the chemical guidance cue semaphorin3A
… stiffness and the mechanosensitive ion channel Piezo1 are important for proper pathfinding of the axons of retinal ganglion cell neurons (RGCs). In an in vitro culture system comprising explanted Xenopus laevis eye primordia, I found that application of the Piezo1 agonist Yoda1 triggered axonal …
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Role of vascular smooth muscle Interleukin-11 in aortic aneurysm development
… and AA development via AT1 receptors and PIEZO1 channels. METHODS: To simulate these BSMKO conditions, aortic VSMCs were pharmacologically treated with AngII and Yoda1. This treatment is expected to enhance calcium influx via AT1 receptors and PIEZO1 channels, resulting in increased …
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Regulation of PIEZO Channels by Membrane Lipids
… mechanosensitive non-selective cation channels, PIEZO1 and PIEZO2. These ion channels have a fundamental role in multiple normal and pathophysiological mechanisms in mammals. Loss- and gain-of-function mutations of both proteins cause disease, yet there are no pharmacological tools available to …
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Understanding the mechanisms of phosphatidylserine exposure in sickle cells
… and PS exposure. It was hypothesized that PIEZO1, a mechanosensitive ion channel, is a potential candidate for Psickle and a major channel for Ca2+ entry in RBCs. Thus, drugs acting on PIEZO1 such as Yoda1, Dooku1 and GsMTx4 were used to examine their effects on Ca2+ entry and PS exposure. …
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Effect of sinusoidal extremely low-frequency electromagnetic stimulation on neurons and glia in a transient stroke model
… by targeting subcellular pathways involving the Piezo1 channel, PI3K/Akt pathway, and Src protein. Overall, ELF-EMS had a beneficial effect on ischemia/reperfusion injury models by improving neurological outcome. This is linked to a protective effect of neurons, a decrease in glial reactivity, …
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Mecanosensibilidad mediada por PIEZO2
… especialmente de la familia Pieza (PIEZO1 y PIEZO2). Por otro lado, existen evidencias sobre la expresión y funcionalidad de las proteínas PIEZO en tejidos no nerviosos, y estudios recientes relacionan la expresión de las proteínas PIEZO con diferentes patologías humanas, …
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The mechanical regulation of Semaphorin3A signalling in the developing Xenopus laevis brain
… I focused on the mechanosensitive ion channel Piezo1 due to data supporting its in vivo requirement for Xenopus retinal ganglion cell axon pathfinding. To replicate increased axon outgrowth on stiff gels, I refined the protocols for compliant gel fabrication and Xenopus eye primordium …
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Stretch Injury Alters Calcium Dynamics and Actin Organization in Human Astrocytes
… in cytoskeleton structure and overexpression of Piezo1, a mechanosensitive ion channel. These findings support the hypothesis that astrocytic calcium dysfunction links immediate trauma pathology to chronic neurodegenerative pathology. Overall, this work captures consequential changes in …
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Intimations on the Development of Effective Treatment for the Prevention of Preterm Birth: β3 Adrenergic Receptor Signaling in the Human Myometrium
… connexin 43 (Cx43). The mechanosensitive channel Piezo1 was identified in the myometrium and showed to promote relaxation using similar mechanisms involving NO and BKCa. Our studies showed that NO mediated S-nitrosation of Cx43 promote a hemichannel state over a gap junction state. Together this …
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Early Onset Alzheimer’s Disease Markers in Mouse Hippocampus Unveiled by Single-Cell Transcriptomic Analysis Following Cranial Radiotherapy
… such as CST3, APOE, APOE, APOJ/CLU, TREM2 and PIEZO1. We also identified downregulation of several ribosomal genes in pyramidal cells of the hippocampal CA1-3 regions in radiated mice. Comparisons between the observed transcriptional changes and markers of Alzheimer’s disease (PMID: 31042697, …
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Functional Investigation of Genetic Determinants of Red Blood Cell Traits
… TLN2), mechanosensitive ion channel activity (PIEZO1, TMC8 ), sphingolipid signalling (PLD1, SPHK1, S1PR2), iron homeostasis (TF, TFR2) and nucleotide metabolism (GMPR, PKLR). To uncover the function of candidate genes in relation to red blood cell development, I established protocols to …
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Adult hippocampal neurogenesis: traumatic brain injury-induced dysregulation and therapeutic potentials of a novel non-invasive nano-pulsed laser treatment
… and glial differentiation. Inhibition of Piezo1, a mechanoreceptor known to regulate neurogenesis, prevented stretch injury-induced miRNA upregulation, reduced proliferation and increased neuronal differentiation of hippocampal NSC. In conclusion, this work support the use of NPLT for the …
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