Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Pick's disease"”.
-
Amyloid seeding assays for the selective amplification of tau aggregates from human brain homogenates
… into amyloid inclusions in a diverse class of diseases called tauopathies. A growing body of biochemical and structural literature has now confirmed that tau takes different disease-specific aggregate conformations, which then propagate throughout the brains of afflicted patients. The …
-
Structural Polymorphism in Tau Filaments: An Implication for Neurodegenerative Diseases
… pathological hallmark of >20 neurodegenerative diseases including Alzheimer's disease, Pick's disease, and progressive supranuclear palsy. In the adult human brain, six isoforms of tau are expressed that differ by presence or absence of the second of the four semiconserved repeats. As a …
-
On the aberrant nature of tau protein: biophysical approaches to characterise and target aggregation in neurodegeneration
… therapeutics that can modify the course of the disease. To achieve this, we have combined the advantages of metadynamic structural biology and bioorthogonal chemistry to investigate the relative contributions of site-specific PTMs to the stability of tau-microtubule interactions. Our …
-
Factors affecting transduction efficiency of pseudotyped viral vectors incorporating alphaviral glycoproteins
… deficient (ASMase-/-) cells derived from Niemann Pick’s disease-model mice more efficiently than the cells from healthy mice (ASMase+/+). Thus alphavirus-glycoprotein pseudotypes hold a potential as suitable vectors for gene therapy/ transfer in Niemann Pick’s Disease-Type A, a genetic …