Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Pichinde"”.
-
Pichinde virus infection of outbred Hartley guinea pigs and mice as small animal models of human Lassa fever
… small animal models of infection with the Pichinde virus as surrogate models of human Lassa fever that can be carried out in a conventional (BSL2 level) laboratory, as Pichinde virus is non-pathogenic in humans. The first study uses mice that are genetically engineered to be deficient in …
-
Cytokine patterns in a comparative model of arenavirus infection: Implications for virulence and control of viral replication
Guinea pig infection with the arenavirus Pichinde provides an animal model for human Lassa fever, a disease that affects 300,000 to 500,000 people a year in western Africa. Low passage Pichinde virus (P2) induces a mild disease with low viremia, while high passage Pichinde (P18) induces a severe …
-
Characterization of a novel mouse model and vaccines for pulmonary pathogens
… vaccine for this disease. The multivalent Pichinde virus (PICV)-vectored TB vaccines elicited strong, functional T cell responses that reduced the bacterial burden in mice. This study supports the continued development of TB vaccines using the PICV vector. Collectively, the research …