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Showing 1 to 3 of 3 for “"Physiologically-based pharmacokinetic modelling"”.
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In vitro metabolism studies to inform physiologically-based pharmacokinetic modelling of mefloquine, ritonavir and proguanil
… One method of doing so is through the use of physiologically based pharmacokinetic (PBPK) modelling. By combining in vitro data with available knowledge on the physicochemical properties of a drug PBPK modelling provides a mechanistic understanding of drug exposure. As such, the in vitro …
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Novel strategies to enhance bumetanide concentrations in the brain in the treatment of neonatal seizures
… further when an OAT3 inhibitor was administered. Physiologically-based pharmacokinetic modelling was employed to predict plasma and brain concentrations of bumetanide in a virtual neonatal population. The simulated brain tissue concentrations of bumetanide in neonates were below the half-maximal …
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In vitro and in silico profiling to assist pharmaceutical development
… On the other hand studies demonstrated that poor pharmacokinetic behaviour was responsible for the majority of drug candidate failures. Therefore the challenge is to be able to keep up with the rate of production to study the in vivo behaviour of so many drugs more rapidly and efficiently. The …