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Showing 1 to 2 of 2 for “"Physiologically based pharmacokinetic modeling"”.
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STATIC AND DYNAMIC FORMS TO IDENTIFY DDI POTENTIAL AND SOURCES OF PHARMACOKINETIC VARIABILITY
… drug development, or MIDD, which employs dynamic modeling forms to determine important aspects to be addressed and included in a clinical trial. Pharmacokinetic modeling techniques can be mechanistic, semi-mechanistic, or non-mechanistic, and may aid in understanding how a drug is eliminated and …
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Model-Guided Transdermal Formulation of 1α,25-Dihydroxyvitamin D3 for Improved Safety and Efficacy
… skin as the rate-limiting step for permeation. A physiologically-based pharmacokinetic-pharmacodynamic (PBPK-PD) model was further established to interpret the complex PK and PD interplay of 1,25(OH)2D3 and guide dosing selection. Based on the modeling and studies in vivo, we were able to …