Global ETD Search
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Showing 1 to 3 of 3 for “"Physiologically Based Pharmacokinetic (PBPK) modelling"”.
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In vitro metabolism studies to inform physiologically-based pharmacokinetic modelling of mefloquine, ritonavir and proguanil
… One method of doing so is through the use of physiologically based pharmacokinetic (PBPK) modelling. By combining in vitro data with available knowledge on the physicochemical properties of a drug PBPK modelling provides a mechanistic understanding of drug exposure. As such, the in vitro …
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Development of a PBPK-based health risk assessment framework for exposure to cerium, gold, silver and titanium engineered nanoparticles
… frameworks. The study managed to apply a physiologically based pharmacokinetic model for ceria nanoparticles to determine biokinetics of ceria nanoparticles, establish whether physiologically based pharmacokinetic models are a good risk assessment tool for ceria, gold, silver and titanium …
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In vitro and in silico profiling to assist pharmaceutical development
… On the other hand studies demonstrated that poor pharmacokinetic behaviour was responsible for the majority of drug candidate failures. Therefore the challenge is to be able to keep up with the rate of production to study the in vivo behaviour of so many drugs more rapidly and efficiently. The …