Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 145 for “"Physiological function"”.
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The Physiological Function of Endothelin-2 in Mice
In order to directly explore the physiological function of ET-2, we generated constitutive, tissue-specific and systemically inducible knockout mice. Global ET-2 deficient mice exhibited severe growth retardation and juvenile lethality. Despite normal milk intake, they suffered from an apparent …
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Investigating the physiological function of BACE1 and its role in metabolism
… protein cleaving enzyme 1 (BACE1). Whilst the function of this enzyme has been well studied within the context of AD, very little is known about its physiological function within healthy organisms. However, studies have identified that BACE1 KO mice are resistant to diet-induced obesity and its …
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Understanding the biochemical properties and physiological function of the protein syncollin
Syncollin is a 16-kDa protein that was originally isolated from the pancreatic zymogen granule. It is now known also to be expressed in the gut, the spleen and in neutrophils. The protein contains intramolecular disulphide bonds and is present both free within the ZG lumen and tightly associated …
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Molecular Interactions and Physiological Function of the Voltage-Dependent Calcium Channel Gamma6 Subunit
… of the VDCC. I also provide a summary of their functional effects, what information any mouse models have provided up until this point, and the clinical relevance of the various subunits of the VDCC. I conclude Chapter I with the specific aims underlying the work laid out within this thesis. In …
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A comparison between conventional and holistic exercise interventions on physiological function in the elderly
Aging is characterised by a decline in physiological function. The rate of this decline can depend on certain lifestyle factors, genetics, and the environment. Although life expectancy is slowly increasing, there is a need to reduce the time spent in debilitated, and non-independent states by …
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Investigating the physiological function of Alzheimer’s disease risk gene Abca7 in the central nervous system
… the goal of this thesis is to explore the normal function of Abca7 in the intact adult brain, which may provide crucial knowledge to understand its role in AD. I developed several mouse lines for studying Abca7 in vivo (Chapter 1), which will become available to the scientific community: Abca7-HA …
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Plant aromatic amino acid decarboxylases: Evolutionary divergence, physiological function, structure function relationships and biochemical properties
Plant aromatic amino acid decarboxylases (AAADs) are a group of economically important enzymes categorically joined through their pyridoxal 5'-phosphate (PLP) dependence and sequence homology. Extensive evolutionary divergence of this enzyme family has resulted in a selection of enzymes with …
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Investigation of the physiological function of TTBK2 (tau tubulin kinase 2), a protein kinase mutated in spinocerebellar ataxia type 11 (SCA11)
… in 2007, emphasised that TTBK2 has a prominent physiological role in the nervous system. When I started my PhD, there was little known about TTBK2 and many fundamental questions about TTBK2 remained unanswered. <br/><br/>In Chapter 3, I describe an initial analysis of TTBK2 substrate specificity …
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Computational Studies of the Concealed Gating Pathways and Electrophysiological Function of the Human Cardiac IKs Channel
… relating protein molecular structure to its physiological function remains a challenge for the next decade and beyond. Protein malfunction underlies many debilitating and life-threatening diseases. A framework relating protein structure-to-function is necessary for elucidating disease …
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Studies of T4 Polynucleotide 5'kinase 3'phosphatase
… infection is not understood. By determining the physiological function of this enzyme, a rationale may be found for having both activities on the same polypeptide chain. In addition, little is known concerning the location of the active sites on the polypeptide chain or if the two activities …
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Molecular characterization of XvlNO1, a myo-inositol 1-phosphate synthase gene from Xerophyta viscosa
… angiosperm which has the ability to resume full physiological function after desiccation. The full-length cDNA for INO1 from X viscosa was isolated using the RACE technique.
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Characterization of the genes and gene products of the acetate-activating enzymes and a novel iron-sulfur flavoprotein from Methanosarcina thermophila strain TM-1
… gene appears to encode a novel protein whose physiological function has yet to be determined.
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Biomechanical structure-function relationships of collagen tissues, B Cell membranes, and amyloid fibers
Mechanical forces are critical to defining the physiological function of biological systems spanning length scales from 1 nm (single molecules) up to 1m (full mammalian systems). This work combines theoretical and experimental mechanics to gain insights into the physiological function of three …
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Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide
… on gastrointestinal and pancreatic exocrine function, its physiological function has not been clarified. Studies were undertaken to elucidate four aspects of the physiology and pathophysiology of this candidate hormone. Firstly, factors affecting the release of human PP (hPP) were assessed in …
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Characterization of multicopper oxidase-related protein and multicopper oxidase-1 in insects
… that TcMCORP is an essential gene and that its function is required for reproduction. An understanding of the role MCORP plays in insect physiology may help to develop new strategies for controlling insect pests. A multicopper oxidase-1 (MCO1) ortholog has been identified in all insect species …
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Do dreams protect sleep? Testing the Freudian hypothesis of the function of dreams
A review of the literature indicates that a physiological function for dreaming has not yet been empirically established. Based on recent findings regarding the neural correlates of dreaming, this study tested the Freudian hypothesis that dreams protect sleep. In order to do this, sleep …
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Regulation Of Acute Myeloid Leukemia Cell Proliferation By E3 Ubiquitin Ligase DCAF15 Control Of Cohesin Dynamics
… and proteasomal degradation. However, the physiological function of DCAF15 remains unknown. Using a domain-focused genetic screening approach, we reveal DCAF15 as an acute myeloid leukemia (AML)-biased dependency. Loss of DCAF15 results in suppression of AML through compromised replication …
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THE EFFECTS OF OBESITY ON PLASMA LEVELS OF OMENTIN, A DEPOT-SPECIFIC ADIPOCYTOKINE
… It has been demonstrated that adipose tissue functions not only as a fat storage depot but also as an endocrine organ. Omentin is a protein expressed and secreted in adipose tissue that increases insulin-stimulated glucose transport. To further elucidate omentin's physiological function, its …
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SYNTHESIS, TESTING AND CRYSTALLOGRAPHIC STUDIES OF ALLOSTERIC MODIFIERS OF HEMOGLOBIN
The major physiological function of hemoglobin (Hb) is to bind, transport and deliver oxygen to tissues; made efficient by endogenous effectors, such as protons and 2,3-diphosphoglycerate. Synthetic allosteric effectors of Hb (AEHs) are also known to modulate Hb oxygen affinity, showing potential …
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