Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 346 for “"Physiological conditions"”.
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Metabolic Adaptations of Ovarian Cancer Metastases to Physiological Conditions and Disease Progression
… are increased in ovarian cancer patients. These conditions, combined with the physiological conditions within malignant ascites (hypoxia and low glucose), represent a physiological environment that can impact the metabolic responses of ovarian cancer spheroids. Here, we investigated the metabolic …
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Effects of Cadmium on Calcium homeostasis and physiological conditions of the freshwater Mussel Anodonta anatina
… on algal growth, cell morphology, size and algal physiological state. The minimum Cd concentration at which the algae were significantly different from the control group was about 3 µg/L. At a Cd concentration of 2 µg/L, algae exhibited a comparable physiological state to the control which was …
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Influence of alloying and processing on the degradation properties of Mg-Dy-Zn alloys under physiological conditions
… tests in DMEM + 10% FBS under cell culture conditions. In the as-cast alloys, Mg-5Dy-1.5Zn contained only small amount of intermetallics which were composed of W, γʹ and 18R LPSO phases and acted as galvanic cathodes, accelerating the degradation of the Mg matrix. With the Dy content …
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Liquid chromatography and mass spectrometry based characterization to understand the role of neuropeptides in various physiological conditions and disease states
… studies has demonstrated their role in several physiological functions such as appetite regulation, nociception, locomotion, reproduction, learning and memory. Given their important role as the molecular messengers of a biological system, there is a lot of interest in the accurate identification …
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A Computational-Experimental Study of Small Globular Proteins
… dynamics simulations are carried out under non-physiological conditions to overcome experimental obstacles. Under physiological conditions, the combination of molecular dynamics and experiments resolves the folding of small proteins in great detail.
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A Computational - Experimental Study of Small Globular Proteins
… dynamics simulations are carried out under non-physiological conditions to overcome experimental obstacles. Under physiological conditions, the combination of molecular dynamics and experiments resolves the folding of small proteins in great detail.
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Maximal short-term power output from human muscle
… and children and its variability under different physiological conditions was examined.
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Investigating the Role of PARylation in Regulating Skeletal Muscle Mass and Function in Healthy Mature Mice
… (i.e., proteins, DNA, RNA, etc.) in response to physiological stressors (i.e., nutrient deprivation, oxidative stress, DNA strand breaks). Poly-ADP-ribosylation (PARylation) is primarily mediated by the family of poly(ADP-ribose) polymerases (PARPs) and enzymatically degraded (dePARylation) by …
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Regulation of Gene Transcription by Estrogen Receptors Alpha and Beta: DNA Binding, Tethering, and Coregulatory Protein Recruitment
… the gene under different cell environments and physiological conditions. These studies will advance our understanding of the complex mechanisms by which ERalpha is able to regulate gene expression.
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Characteristics of sodium transport through the amiloride-sensitive sodium-magnesium pathway in hamster red cells
… of intracellular Mg$\sp{2+}$ concentration under physiological conditions.
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Renal blood flow in the conscious, unrestrained rat
… renal blood flow remains constant under normal physiological conditions. Methods were developed for long term studies of renal blood flow (using the Doppler flow probe) and blood pressure in the conscious unrestrained rat. Special care was taken to maintain and observe the rats under normal, …
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Preparation of Supramolecular Amphiphilic Cyclodextrin Bilayer Vesicles for Pharmaceutical Applications
… guest molecules in buffer solution that mimics physiological conditions. The solution is subject to freeze-thaw cycles and extrusion, and the complexes are separated out via size exclusion chromatography. Dynamic Light Scattering instrumentation is used to observe the particle size distribution. …
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Development of synthetic RNA-targeting catalysts from biostable nucleic acid analogues
… of targeting disease-associated RNA under physiological conditions. This approach seeks to overcome the limitations of other RNA knockdown methods, principally the lack of single-nucleotide specificity and off-target effects, and—in the case of ribozyme and DNAzyme catalysts in …
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Haemozoin formation, effects of chloroquine on iron distribution in Plasmodium falciparum and the correlation of thermordynamic and structural factors with 4-aminoquinoline activity
… a lesser extent at toluene/water interface under physiological conditions of pH and temperature and does not form at all in the absence of the interface.
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Physico-Chemical Characterisation of Disease-Related Protein-Protein Interactions in Solution
… significantly higher than those relevant under physiological conditions. Microfluidic diffusional sizing offers an alternative method for investigating protein-protein interactions and protein assembly under physiological conditions and has been applied to investigate a wide range of protein …
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Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity
… or protein stability and folding, leaving physiological or native roles for the UPR relatively uncharacterized. Richardson et al previously demonstrated a role for the UPR in innate immunity in C elegans. Here, in an effort to understand this role, we demonstrate that intestinal expression …
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Endogenous atrial natriuretic factor and airway control
… hyperresponsiveness in humans under normal physiological conditions. Two approaches are used. One approach examines the diurnal variation of endogenous ANF and its effect on the airway function of asthmatics and non-asthmatics. The second approach analyses a change in bronchoresponsiveness …
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Studies towards degradable polymers new zinc (II) and palladium (II) complexes as catalysts for lactide polymerization and carbon monoxide
… displayed slow drug release properties under physiological conditions. Palladium complexes were utilized for the production of a photodegradable CO/styrene copolymer (CP) which was subsequently reacted with lactide to form a new poly(lactide-co-CO/styrene) block copolymer.
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Nanoclusters for Cancer Therapy: Assesment of Their Reactive Oxygen Species Generation and Stability
… and properties of nanoclusters are affected by physiological conditions. This is critical for the advancement of nanoclusters, since the properties of clusters are highly structure-dependent and clusters are sensitive to their conditions. In this thesis: 1) Our understanding of nanoclusters and …
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