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Showing 1 to 16 of 16 for “"Physical Organic Chemistry"”.
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Mechanistic studies on metal-catalyzed carbon-nitrogen bond forming reactions
… of these processes, several principles of physical organic chemistry have been employed. Chapter 1. We have investigated the mechanism of the copper-catalyzed N-arylation of amides using aryl iodides, i.e., the Goldberg reaction. The focus of the work has been directed towards amides since …
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Bioorthogonal Reagents: Design, Synthesis, and Reactivity
… that fit the stringent criteria for click chemistry and bioorthogonal chemistry has enabled discoveries and applications in fields ranging from materials science to chemical biology. These reactions must proceed rapidly and selectively under mild conditions. This enables the chemistry to be …
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Aromaticity Across States: A Framework for Reactivity and Structure in Organic Systems
… the stability, structure, and reactivity of organic molecules. In the ground state, [4n+2] π-systems are stabilized by aromaticity, while [4n] π-systems are destabilized by antiaromaticity. Upon photoexcitation, these rules invert, as described by Baird’s rule, making aromaticity a dynamic …
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Large scale simulation and analysis to understand enzymatic chemical mechanisms
… through a combination of knowledge from physical organic chemistry, local energetic optimizations, and experimental information. The activation barriers were converted to reaction rates and simulated with mass action kinetics. The results show the slow-down in one turnover for the enzyme …
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Enantiomeric separations by HPLC:temperature, mobile phase, flow rate and retention mechanism studies
… Relationships (QSRR). Some structure-specific physical-organic chemistry parameters are determined using an EPA-developed computer program and correlations are made between retention on a given CSP and some of the parameters.
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Coacervate protocells as reaction centres at the origin of life
Contains fulltext : 325221.pdf (Publisher’s version ) (Closed access)
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To signal or not to signal: Molecular information processing through the B-cell signalling network
Contains fulltext : 321287.pdf (Publisher’s version ) (Open Access)
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Processive bio-hybrid catalysts based on the T4 clamp protein
Contains fulltext : 72127.pdf (Publisher’s version ) (Open Access)
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Functionalizing Synthetic Cells: Membranes and Condensates
Contains fulltext : 295327.pdf (Publisher’s version ) (Open Access)
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Precipitation of barium carbonate nanoparticles within water-in-oil microemulsion systems: relations between particle growth and surfactant environment
Contains fulltext : 72087.pdf (Publisher’s version ) (Open Access)
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Measuring and manipulating charge in coacervates
Contains fulltext : 320396.pdf (Publisher’s version ) (Open Access)
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Functional materials of self-assembled compounds
Contains fulltext : 74876.pdf (Publisher’s version ) (Open Access)
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Non-Covalent Interactions in Water Using Synthetic and Biological Receptors
… to use protein-templated dynamic combinatorial chemistry to speed up the structural optimisation of multivalent molecular probes that bind amyloid fibrillar aggregates. Building blocks consisting of amyloid-binding probes and linkers have been synthesised and attempts at equilibrating a dynamic …
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Towards a synthetic metabolism: exploitation of synthetic and natural nucleotide synthesis pathways for in vitro gene expression
Contains fulltext : 175865.pdf (Publisher’s version ) (Open Access)
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Development of New N-Cyclopropyl Based Electron Transfer Probes for Cytochrome P-450 and Monoamine Oxidase Catalyzed Reactions
… in utilizing the fundamental principles of physical organic chemistry to understand biological problems. Enzyme pathways can pose several experimental complications due to their complexity, therefore the small molecule probe approach can be utilized in an attempt understand the more complex …
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Quantifying Cooperativity in Non-Covalent Networks
… material, systems, and supramolecular chemistry. Some quantification of cooperativity in networks of non-covalent interactions has been done in the literature, but these experiments are often complex and not easily applicable to many different types of functional group. The work in this …