Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Photothermal Therapy"”.
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Ultrasound and photoacoustic imaging to guide and monitor photothermal therapy
Photothermal cancer therapy is a potential alternative to surgery and involves selective tissue destruction using thermal energy. Targeted photoabsorbers, used in conjunction with matching a continuous wave laser, make photothermal therapy both noninvasive and tumor-specific. However, to become …
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Polymer Dynamic Organic Theranostic Spheres for Photothermal Therapy and Fluorescent Imaging of Cancer
Nanoparticle mediated photothermal ablation of cancer is a promising technique that utilizes light energy to destroy cancer cells. Specifically, nanoparticles that absorb in the near infrared (NIR) region of light, 700 - 900 nm, are optimal because these wavelengths are an absorption minimum for …
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Induction of Immunogenic Cell Death via Nanoparticle-Mediated Dual Chemotherapy and Photothermal Therapy
… modalities have been developed for cancer therapy. Recently, immune checkpoint (ICP) therapy has demonstrated promising results. However, low response rates, cancer recurrence and side effects are remaining problems. In this work, we aimed to develop formulations to enhance the …
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Harnessing the optical properties of gold nanorods: fluorescence enhancement, biosensing and photothermal therapy
… sensing, bioimaging, drug delivery, and cancer therapy. Excitation of a gold nanorod localized surface plasmon resonance (LSPR) can result in the enhancement of many photophysical processes such as light absorption, Rayleigh (Mie) scattering, and fluorescence. The presence of a strong …
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Single Walled Carbon Nanohorns as Photothermal Absorbers, and Incorporation of Spatial Digital Image Analysis into Cancer Diagnostics and Therapy
Background: Photothermal therapy is an actively researched cancer treatment alternative to chemotherapy and resection due to its potential as a minimally invasive treatment with fewer health complications than high energy radiation therapies. The effectiveness of photothermal therapy may be …
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Applications of Ephb4 Receptor Specific Peptides In Targeted Cancer Imaging and Therapy
… early detection rates, monitor response to therapy directed against EphB4, and improve patient outcomes. Targeted delivery of EphB4 receptor specific peptide conjugated hollow gold nanoshells (HAuNS) into tumors has great potential in cancer imaging and photothermal therapy. In this study, …
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NANOPARTICLE BASED MULTI-MODAL THERAPIES AGAINST TRIPLE-NEGATIVE BREAST CANCER
… for the development of a multimodal cancer therapy that uses a selectively cytotoxic particle that sensitizes cancerous cells to ionizing radiation and can act as a photothermal therapy heat transducer. Using a 90 nm triangular silver nanoparticle plate (AgNPP) allows for the nanoparticle to …
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Fluorinated Graphene Oxide: structure, morphology and its potential use in biological applications
… contrast agent, drug carrier as well as a photothermal therapy. FGO is a sheet like material with oxygen and fluorine functional groups present in the structure, a complete characterization of the material is offered in the following pages. Non-cytotoxic FGO exhibited paramagnetic behavior …
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Phosphonium-functionalised gold nanoparticles for mitochondria targeted therapeutics.
… for other therapeutic applications such as photothermal therapy. Cellular uptake studies of phosphonium ligands by MALDI-MS showed that they are rapidly taken-up by cells within ten minutes.Phosphonium-functionalised gold nanoparticles are soluble in biological media which is of great …
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Development of N-heterocyclic carbene ligands for nanomaterials in aqueous media and expanding the interface of metal-organic framework (MOF) and polymer chemistry via polyMOFs
… a bidendate NHC-thiol to modify gold NRs for photothermal therapy. (2) We examine the interface between amorphous polymers and crystalline metal organic frameworks (MOFs) in an emerging class of materials called polyMOFs. PolyMOFs use polymer ligands as their building blocks, opening the door …
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Gold nanorod based nanoprobes for biomedical applications
… gold nanorods (LGNRs), making the SGNRs good photothermal agents. Moreover, the SGNRs have ease of subcellular accessibility, high internalization rate and large surface area to volume ratio for binding of analytes. These attributes make the SGNRs good candidates in various biomedical …
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Polymer- and Bioadditives-Assisted Synthesis and Surface Modification of Anisotropic Gold Nanocrystals
… applications such as radiosensitization and photothermal therapy of cancer.
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PREPARATION OF NANO- AND MOLECULAR COMPOUNDS FOR ANTITUMORAL APPLICATIONS TRIGGERED BY LIGHT
… of these systems was based on the photodynamic therapy (PDT), often to combine it with a secondary antitumoral strategy to enhance its efficiency. A smaller part of the thesis was instead devoted to the preparation of a luminescent metformin derivative to investigate the antitumoral activity of …
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Design strategies and application of stimuli-responsive nanoparticles for cancer diagnosis and therapy
… molecule anticancer drugs are the first-line therapy used in clinical cancer management which has shown success in the killing of rapidly dividing cancer cells. However, nonspecific distribution of these small molecular therapeutics has adverse side effects reducing the quality of life. …
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Interaction of the potential DNA-radiosensitizer 8-bromoadenine with free and plasmonically generated electrons
… it the second most common cause of death. Chemotherapy and radiation therapy are often combined to exploit a supra-additive effect, as some chemotherapeutic agents like halogenated nucleobases sensitize the cancerous tissue to radiation. The radiosensitizing action of certain therapeutic agents …
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Manipulation and Characterization of Morphology and Composition in Mono- and Heterometallic Nanoparticles
… data storage devices, plasmonics, photothermal therapy and (electro)catalysis. This thesis is divided into two distinct sections. The first section reports the synthesis of core@shell NPs for applications in data storage or plasmonics. The synthetic development of FePt@Fe3O4 by the …
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Bioenabled Synthesis of Anisotropic Gold and Silver Nanoparticles
… them promising materials for biosensing and photothermal therapy. Since the Ag nanoprisms are susceptible to morphological deformation in the presence of strong oxidant, they also hold great potential for the colorimetric sensing of oxidative metal cation species such as Fe3+, Cr3+, etc.
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Photothermal properties and applications of gold nanorods
… nanorods (GNRs) with their special optical and photothermal properties have attracted attention recently for their potential applications in fields such as photothermal therapy, drug delivery, biomedical imaging and chemical sensing. These anisotropic gold nanocrystals have tunable surface …
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Engineering the Optical Properties of Gold Nanostructures for Biomedical Applications
… with an aim to use them as imaging agents and photothermal transducers for the diagnosis and treatment of cancer. I have produced Au nanocages with hollow interiors and porous walls using the galvanic replacement reaction between Ag nanocubes and AuCl<sub>4</sub>-. I have engineered these Au …