Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Photosensitisers"”.
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New photosensitisers for photodynamic therapy
… dyes based on Victoria Blue, a class of cationic photosensitisers which show promise for PDT, have been synthesised via their leuco bases from novel and known derivatives of benzhydrol and of 1-naphthylamine. A new synthesis of derivatives of the latter has been successfully developed and the …
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Nanoparticles and photosensitisers; their interactions and antibacterial properties
… were tiopronin and glutathione. The photosensitisers attached to the thiols were toluidine blue and tin chlorin e6 respectively. It was found gold-tiopronin-toluidine blue nanoparticles at 1 µM concentration were efficient as light activated antimicrobials, that had a reduction of …
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Iridium (III) photosensitisers for photoredox catalysed carboxylation reactions of ketimines
… design when developing efficient and versatile photosensitisers, and reveal that the benzimidazole scaffold may not be the most well-suited N^N ligand for this application.
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The Photophysics and Photochemistry of a series of Phthalocyanines as Potential Photosensitisers in Photodynamic Therapy
Abstract The photophysical and photochemical measurements have been made on 3 series of novel alpha octa(alkyl-substituted) phthalocyanines. Each series is defined by the distinct non-metal or metal ion centre, silicon hydroxide, zinc(II) and palladium(II). It is well documented that the …
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The synthesis of aza-dipyrromethenes as potential pdt agents and measurement of singlet oxygen generation.
… (1O2) after light irradiation. Current approved photosensitisers have limitations, such as a low extinction coefficient in the desired therapeutic wavelength of absorption (600 “ 900 nm), as in the case of Photofrin®. The discovery of improved photosensitisers is essential if photodynamic …
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Development of porphyrin-antiangiogenic antibody immunoconjugates for photodynamic therapy
… species. Currently, commercially available photosensitisers, including Photofrin and Foscan, only exhibit a passive selectively towards cancerous tissue. Therapeutically, this results in a variety of unfavourable characteristics, obstructing PDT from becoming a more viable cancer treatment. …
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Investigation into the toxicity and membrane interactive properties of a range of cationic photosensitisers with potential application to Photoantimicrobial Chemotherapy
… potential of a series of phenothiazinium based photosensitisers (PhBPs) to act as novel photodynamic antibacterial agents is investigated. It is shown that Azure A, Azure B, Azure C, Brilliant Cresy! Blue, Neutral Red, Pyronin Y, To!uidine Blue 0, New Methylene B!ue and Dimethylmethylene Blue …
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Investigation into the toxicity and DNA interactive properties of a range of cationic photosensitisers with potential application to photodynamic antimicrobial chemotherapy
… PhBPs is generally 0.7 or above, showing these photosensitisers to be lipophilic and suggesting an ability to interact with either lipid or membranes. Additionally, the singlet oxygen yield ((D 1 ) of these PhBPs is generally 0.77 or above, consistent with high levels of singlet oxygen …
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The Development and evaaluation of photo-antimicrobial isoalloxazine dyes towards infection control
… we report the development of a range of novel photosensitisers based on the second generation photodynamic therapeutic dyes (PDT) that are based on the tricyclic isoalloxazine structure of riboflavin, vitamin B2. Photosensitisers were synthesised using similar strategies to the isoalloxazine …
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Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer
… generators of singlet oxygen and are used as photosensitisers in PDT. They are also known to accumulate in tumour tissue due to the hyperpermeability of tumour vasculature and poor lymphatic drainage, thus exhibiting a passive tumour targeting property. Functionalised tetraazamacrocycles based …
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Studies on the natural fluorescence of wool and wool grease
… on their own and upon irradiation acted as photosensitisers causing extensive photobleaching. The difference between the two groups was attributed to the pH of the solutions used. The whitenin gobserved was (generally)d uet o the destruction of visible absorbing chromophore rsather than to …
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Polyacrylamide nanoparticle delivery systems in photodynamic therapy
… nanoparticles were chosen to deliver photosensitisers due to the chemical and biological inertness of polyacrylamide, in addition to its optical transparency. The porous three-dimensional particles produced from microemulsion polymerisation reactions are typically prepared in the …
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Tailoring the redox enzyme-material interface for enhanced electro- and photocatalytic fuel synthesis
… non-covalent attachment to electrodes and photosensitisers enables substrate conversion at high efficiencies, in both cases, stability is limited to hourly timescales, the reasons for which remain convoluted. This ambiguity stems from the need for a more thorough characterisation of the …
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Expanding the versatility of aminoquinoline organometallic complexes as anticancer and antibacterial agents
… given to the development of metal complexes as photosensitisers based on their attractive photophysical and biological properties. The aminoquinoline motif has been recognised as a remarkably versatile pharmacophore owing to its paramount contribution in the clinical success of the historical …
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Photochemical synthesis of dihydroquinolinones and their investigation toward macrocycle synthesis via ring expansion
… can be accessed using inexpensive thioxanthone photosensitisers.3 A related demethylation of amides was reported by Yi et al using a Cu catalyst and NFSI as an oxidant7 and in our attempt to use this procedure to produce the unprotected DHQ, we obtained the unsaturated quinolinone, instead. …
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Development and characterisation of photosensitiser-incorporated polymeric microparticles
This thesis details the production and characterisation of a range of photosensitiser (PS)- incorporated polymeric microparticles, optimising the photodynamic antibacterial activity exerted. Specifically, their ability to reduce the bacterial bioburden of solutions, with low visible light …