Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 138 for “"Photoreceptors"”.
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Optical photoreceptors for CMOS neural circuitry.
… in this thesis relates to the design of photoreceptors fabricated in Northern Telecom's 3$\mu$ CMOS process. The photoreceptor consists of a vertical BJT whose output current is fed to four diode connected MOSFETs. Results of the experiments used to characterize the device both optically …
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Structural and Spectroscopic Characterization of Modular Photoreceptors
Photoreceptors are signaling proteins that perceive a light signal and generate light-dependent biochemical responses. Cyanobacteriochromes (CBCRs) from photosynthetic cyanobacteria are an emerging family of bilin-based photoreceptors that are compact in size and diverse in absorption spectra. …
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Synaptojanin1 is involved in endolysosomal trafficking in cone photoreceptors
… vulnerable to defects in protein turnover. Photoreceptors are highly polarized, specialized neurons that have high protein trafficking demands. At one end of the photoreceptor is the outer segment; the site of photon detection and phototransduction. The outer segment requires a constant …
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Genetic Analysis of Fic-Mediated BiP AMPylation in Photoreceptors
… degeneration-like phenotypes are reversible: photoreceptors in both fic and bip mutants regain their structure and function within 72 hours once returned to a standard light:dark cycle. In fic mutants, these phenotypes are preceded by a dysregulation of the IREI and PERK-mediated ER stress …
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Controlled ablation of rod photoreceptors in transgenic Xenopus laevis
… Loss of a certain group of neurons called rod photoreceptors can occur as the result of genetic mutation. In humans, and in mammalian models of retinal degeneration, the death of these cells is permanent, and often followed by cone photoreceptor death, which leads to blindness. As a step …
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Mechanistic and Engineering Studies of LOV Photoreceptors in Yeast
… (LOV) domains in particular, are a group of photoreceptors that respond to blue wavelengths of light and can become a cellular photoswitch by converting this stimulus through their attached effector domains. For instance, the Helix-Turn-Helix (HTH) DNA-binding activity of the bacterial …
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Structural Basis for Signal Transduction in LOV Blue Light Photoreceptors
This research focused on studying the mechanisms of signal transduction within Light-Oxygen-Voltage domains, a subset of the PAS domain family. The first of two projects addressed intradomain signaling from the hydrophobic core to the domain surface. In this study, we addressed the role of a …
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Bioinformatics Discovery And Functional Characterization Of Lipid-Binding Lov Photoreceptors
… multiple kingdoms to sense blue light. LOV photoreceptors are modular flavin-binding proteins that consist of discrete sensor and effector domains. Blue-light drives a LOV sensor to trigger a conformational change in photoreceptor structure that ultimately regulates the biochemical function …
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Efficient In Vitro Development of Photoreceptors from Human Pluripotent Stem Cells
<p>Degeneration of the rod and cone photoreceptors in the human retina is among the most common causes of blindness. Replacing these damaged photoreceptors may help to restore vision. Repairing the damaged retina relies on the insertion of new, healthy cells. Embryonic stem (ES) cells and induced …
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A Comparison of Light-Activated Enzymes From Vertebrate and Invertebrate Photoreceptors
… search for light-activated enzymes in octopus photoreceptors analogous to those found in vertebrates' photoreceptors, (2) the question of which photointermediate(s) of photoexcited rhodopsin activate bovine photoreceptor GTPase, and (3) the calcium and pH dependence of phosphodiesterase in …
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Maguk Scaffolds Organize A Key Synaptic Complex In Horizontal Cell Processes Contacting Photoreceptors
… cell processes where they contact cone and rod photoreceptors. We further identified some known SAP102 binding partners, kainate receptor GluR6/7 and inward rectifier potassium channel Kir2.1, closely associated with SAP102 in the processes of invaginating HCs. In contrast, in the mouse retina …
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Influence of protein and solvent environments on quantum chemical properties of photosynthesis enzymes and photoreceptors
This thesis contains quantum chemical models and force field calculations for the RuBisCO isotope effect, the spectral characteristics of the blue-light sensor BLUF and the light harvesting complex II. The work focuses on the influence of the environment on the corresponding systems. For RuBisCO, …
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The Role of the Scaffolding Protein INAD in Localization of Signaling Complexes to the Rhabdomeres of Drosophil Photoreceptors
… efficiency of signal transduction. In fruit fly photoreceptors InaD, a scaffolding protein containing 5 PDZ domains, organizes proteins involved in the visual signaling pathway into complexes within a microvillar stack of membranes known as the rhabdomere. Light activation of rhodopsin activates …
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Structural, molecular and functional characterisation of visual photoreceptors and opsins in sole: an ontogenetic, chronobiological and environmental approach
La metamorfosis de los peces planos está acompañada de cambios drásticos, que determinan una reorganización total del cuerpo, una remodelación cráneo-facial y la migración de los ojos hacia el lado ocular superior, que transforma a las larvas simétricas en juveniles asimétricos. Durante la …
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The effects of the tubulin-binding drug, colchicine, on the electrophysiological aspects of phototransduction in toad rod photoreceptors
Colchicine, known for its antimitotic properties, its effects on neuronal conductances and its use as a treatment for acute gout, was found to affect phototransduction in toad rods during pharmacologic screening of cytoskeletal antagonists. Colchicine superfusion onto intact retinas hyperpolarized …
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Inflammasome upregulation and activation in photoreceptors of type 2 diabetes and N-methyl-N-nitrosourea models is attenuated by Wedelolactone
… vitro and in vivo, respectively. Protection of photoreceptors comes through downregulation of the AIM2/CASP11/CASP1/IL1B signalling pathway. The inflammasome pathway is upregulated and activated in the retina of T2DM, but not T1DM. Palmitic acid may play a pivotal role in obesity-induced …
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Rod Photoreceptor Regeneration in a Zebrafish Model with Retinitis Pigmentosa
… degenerative diseases is progressive loss of photoreceptors until one is completely blind. Unlike mammalian models, Zebrafish have the ability to naturally regenerate their neurons after injury or disease is detected. We have generated a zebrafish model with the most common autosomal dominant …
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Optimizing CRISPR/Cas9 Gene Targeting to Investigate Cone Photoreceptor Development in the Chick Retina
… loss of vision, due to the degeneration of cone photoreceptors in the retina. Thus, the development of methods to regenerate these cone photoreceptors is an active area of study. In order to find ways to regenerate cones, the molecular pathways and gene regulatory networks that a retinal …
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Generation and circuit development of zebrafish retinal horizontal cells
… function to modulate information transfer from photoreceptors. I examined the genesis of HCs using in vivo multiphoton time-lapse microscopy in the zebrafish retina and discovered a novel precursor cell that is dedicated to the generation of HCs. In contrast to the classical germinal cell, the …
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Retinal development and age related degeneration following gestational lead exposure
… increase in two late-born retinal neurons: rod photoreceptors and bipolar cells. The present goals were to examine: 1) the spatiotemporal differentiation and functional development of these two cell types, 2) the profile of glutamatergic responses in developing retina prior to canonical synaptic …
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