Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Photoreceptor Cells"”.
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Steroid induced neuroprotection of damaged photoreceptor cells
… Norgestrel worked. To this aim, the 661W cone photoreceptor-like cell line and ex vivo retinal explanting was utilised. We found that Norgestrel induces a increase in neuroprotective basic fibroblast growth factor (bFGF) with subsequent downstream actions on the inhibition of glycogen synthase …
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Light deprivation and presumed photoreceptor cells in Hydra littoralis
Typescript (photocopy).
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Multi-Scale Structure and Dynamics of Visual Signaling in Drosophila Photoreceptor Cells
A general problem in science today is how to understand complex systems. An emerging and promising approach makes the bold assumption that complex systems adhere to particular design principles. The power of this is that design principles by definition impose an intuitive nature on a system by …
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Glucose metabolism in the outer segments of photoreceptor cells : its involvement in the phototransduction process
… of glucose metabolism in the outer segments of photoreceptor cells were investigated using biochemical and immunocytochemical approaches. The presence of glycolytic enzymes in photoreceptor outer segments was detected by enzyme activity assays, Western blotting, and immunofluorescence …
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Spatial, temporal and spectral properties of photoreceptor cells in the fiddler crab Uca pugilator (Bosc, 1802)
… not yet completely understood, especially at the photoreceptor level. The objective of my thesis has been to fill this gap in knowledge, and specifically determine the spatial, temporal and spectral properties of photoreceptor cells through an integrative approach, using several molecular and …
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Functional studies of <i>Ci-Gsx</i> gene in the developing central nervous system of <i>Ciona intestinalis</i>
… CNS, including the precursors of the ocellus photoreceptor cells. Clana ocellus, a pigmented multicellular photoreceptive organ, despite its simplicity, possesses functional and molecular similarities to vertebrate eye, thus representing a valuable tool to study the basic mechanisms of eye …
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Effect of Melatonin and Dopamine in Site Specific Phosphorylation of Phosducin in Intact Retina
… dimer (G-beta-gamma) found abundantly in the photoreceptor cells of the retina and pineal gland. In the retina, light-dependent changes in cAMP and Ca2+ control the phosphorylation of Pdc at serine 73 and 54, respectively, which in turn controls the binding of Pdc to G protein beta gamma …
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Mechanism of activation of photoreceptor phosphodiesterase by transducin and by low molecular weight proteins
<p>Rod photoreceptor phosphodiesterase (PDE) is the central enzyme of visual transduction. PDE is a heterodimer (Palphabeta) with two associated inhibitory gamma subunits, and is bound to the disk membrane by isoprenyl groups. Each catalytic subunit contains a catalytic site and a high-affinity …
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Inflammasome upregulation and activation in photoreceptors of type 2 diabetes and N-methyl-N-nitrosourea models is attenuated by Wedelolactone
… mitochondrial dysfunction in various retinal cells where it can manifest as loss of organelle membrane integrity and porosity, leading to the extravasation of mtDNA. In such scenarios, AIM2 inflammasome signalling is activated in response to DNA-sensing, leading to inflammation and cell death. …
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Functional analysis of A 5' untranslated variant in rhodopsin : implications for the retinitis pigmentosa phenotype
… diseases that predominantly affect rod photoreceptor cells. Symptoms include night blindness and gradual peripheral vision loss, which progresses to a complete loss of vision. Clinical, phenotypic and genetic heterogeneity are frequently observed in RP. Mutations in Rhodopsin (RHO) have …
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Deciphering Underlying Mechanisms Of Photoreceptor Outer Segment Degradation; Involvement Of Intracellular Trafficking
… AMD is characterized by the degeneration of photoreceptors and retinal pigment epithelium (RPE) cells in the macula region of the retina. RPE maintain the health of the retina by providing support to the photoreceptor cells and the retina through various tasks. One major task RPE cells are …
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FOXO is the Mediator Linking Temporal Differentiation and the Insulin Signaling Pathway
… can be used reiteratively to differentiate cells. Until recently, the molecular mechanism behind the temporal control of differentiation has remained elusive. Bateman and McNeill (2004) revealed a novel role for the insulin/insulin-like growth factor receptor (InR) pathway in regulating the …
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Biochemical Investigations of Macular Degeneration: The Significance of Protein Oxidation including Novel Methods for Its Study
… pigment epithelium (RPE) is a monolayer of cells located directly behind the photoreceptor cells in the retina. These cells are involved in a variety of functions that support the visual process in the eye, namely 1) they form a blood-retina barrier which separates the neural retina from the …
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Genetic analysis of the maintenance of neuronal morphology in Drosophila melanogaster
… In the developing Drosophila eye, normal photoreceptor cells establish and maintain a highly polarized architecture, with cell bodies and nuclei located apically in the epithelium, and axons extending basally into the brain. Disruption of the Dynactin complex, which activates the …
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Cell Death Mechanisms in Drosophila Differentiated Photoreceptor Neurons
… the Drosophila retina, cell death terminates and photoreceptor neurons complete their differentiation process. We use these terminally differentiated photoreceptor neurons as a system to study neurodegeneration. We first adapt and develop fluorescent tools for photoreceptor visualization in vivo. …
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A microfabricated 3-D stem cell delivery scaffold for retinal regenerative therapy
… (RP), result in the degeneration of the photoreceptor cells and can ultimately lead to blindness in patients. There is currently no cure for AMD or RP, and only a few methods exist for slowing the progression of these diseases. Although there has been much recent headway in cell …
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Real-time image-based cell identification
… limit its subsequent use. For example, for photoreceptor transplantations, highly pure samples of photoreceptor cells are required, which can currently only be obtained using molecular labelling, rendering the resulting sample incompatible for clinical application. A promising alternative to …
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Development of selective high-affinity fluorescent sensors for imaging neurotransmitters and application in cells and tissue
… and fluorescence) and their applications in cells and tissue. NeuroSensor 510 (NS510) was designed and synthesized as a selective sensor for imaging norepinephrine. Formation of both an iminium ion and a boronate ester gave high affinity upon binding NS510 to norepinephrine. The sensor was …
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Evolution and functional specializations in nocturnal environments: insights from visual pigments in Chiroptera
… pigments, light-sensitive complexes expressed in photoreceptor cells in the retina that have been shown to evolve in response to changes in ecology and light environment. In this thesis, I employ molecular evolutionary analyses and experimental characterization of visual pigments to study the …
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Unravelling the genetic relationships between auditory processing and speech and language
… loss resulting from dysfunctional neurosensory cells in the inner ear and retina (hair cells and photoreceptor cells respectively). Analyses indicate that there is no one single risk variant, but a complex mix of variation across Usher genes (such as USH2A, PCDH15, CLRN1, and ADGRV1) might …
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