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Showing 1 to 14 of 14 for “"Photonic crystal enhanced fluorescence"”.
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Photonic Crystal Enhanced-Fluorescence and Label -Free Bioimaging
… work, a theory is outlined for predicting photonic crystal label-free imaging resolution based on resonance spectral characteristics. Devices are characterized by patterning a resolution standard onto the sensor using photolithography, and excellent design control over label-free imaging …
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Highly sensitive biosensors using photonic crystal enhanced fluorescence
Due to the importance of fluorescence assays in clinics, life science and genomic research, many nanostructures have been proposed to enhance the weak fluorescence signals from low abundance analytes. Among these structures, photonic crystal (PC) has attracted particular attentions because of its …
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Improved microarray sensitivity using photonic crystal enhanced fluorescence
… the proliferation of research on modifying fluorescence with optical resonances, there have been few evaluations of the practical impact of enhanced fluorescence on high-throughput biological assays such as microrarrays. This work details the application of photonic crystal (PC) surfaces as …
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Cavity coupled photonic crystal enhanced fluorescence for high sensitivity biomarker detection
With the rise in fluorescence-based testing of biomarkers in samples, the use of dielectric optical resonators has increased dramatically. These photonic crystals make fluorophores emit more light through a process called enhanced fluorescence which in turn allows for more signal to be collected …
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Optimization of photonic crystal enhanced fluorescence by excitation laser angle scanning
Photonic crystal enhanced fluorescence (PCEF) has been demonstrated as an effective means for amplifying the excitation provided to surface-bound fluorescent molecules while simultaneously enhancing fluorescence emission collection efficiency. Optimal coupling of a fluorophore-exciting light source …
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Photonic crystal enhanced fluorescence for single-molecule biosensing and early disease detection
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Designing, construction and analysis of line-scanning detection instrument for photonic crystal enhanced fluorescence
… portable line-scanning detection instrument for photonic crystal enhanced fluorescence. In order to increase the fluorescence signal for low-concentration detection, we introduced the photonic crystal enhanced fluorescence detection modality and demonstrated that it is a very effective approach …
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Sensitive microarray-based biomarker detection using photonic crystal enhanced fluorescence and label-free imaging
Fluorescence-based biomarker detection in serum, saliva, urine, or breath condensate samples holds great promise for disease diagnostics and therapy monitoring because of its non-invasive nature. The microarray format, for its high-throughput and low analyte consumption characteristics, is …
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Evanescent field enhanced fluorescence on a photonic crystal surface
Photonic crystal (PC) surfaces have been demonstrated to be a compelling platform for improving the sensitivity of surface-based fluorescent assays used in disease diagnostics and life science research. PCs can be engineered to support optical resonances at specific wavelengths at which strong …
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Advanced photonic crystal enhanced microscopy
This study seeks to expand the field of photonic crystal enhanced microscopy by extending simple proof-of-concept experiments to advanced biological applications. There are four distinct projects that are related to a central theme: sophisticated microscope instrumentation for photonic crystal …
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Silicon based photonic crystal coupled to an optical cavity for highly sensitive biodetection
… by Sir John Frederick William Herschel in 1845, fluorescence detection technology has developed extensively to be used in disease diagnosis, DNA sequencing, cellular imaging, flow cytometry, forensics, and monitoring processes in biological systems. In order to achieve better sensitivity and …
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Next generation instrumentation for photonic crystal biosensors: a passage to early detection of cancer
… a biomarker detection approach done using photonic crystal enhanced fluorescence (PCEF) instrumentation as the best way to achieve this goal. We introduce a model for predicting enhanced fluorescence (EF) performance of a photonic crystal (PC) in the context of a given set of instrument …
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Photonic crystal enhanced light emitters and their use in improving cancer screening and disease progression monitoring
… patient outcomes. This dissertation describes a photonic crystal-based detection and analysis system to improve cancer screening and treatment by increasing sensitivity to low concentrations of cancer biomarkers. There are two main methods of increasing sensitivity: automating detection and …
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Study and development of plasmonic biosensors for biomedical applications
… the design, fabrication, and characterization of photonic crystal (PC) and plasmonic nanostructures, both of which employ the resonantly enhanced near-field effect for biosensing applications. The near-field enhancement around PC surfaces is exploited to increase fluorescence emission from the …