Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Photocage."”.
-
Design, synthesis and characterization of photocage molecules for light-activated release: Applications in polymer chemistry and phototherapeutics
ABSTRACT Photocages are photo-protecting groups that can release a covalently linked cargo on irradiation with a light of a particular wavelength. This characteristic of the photocages allows them to have precise spatial and temporal control over the release of substrates over time. But most of the …
-
Chemi-Optogenetics: Photoactivatable Probes To Control Protein Proximity And Cellular Processes
… for probing cellular processes. The removal of a photocage is irreversible and done with a single pulse of light, which enables us to study submicron targets that move quickly within three-dimensional space. This would be otherwise unfeasible with reversible systems such as photo-switches or …
-
Towards Photoredox-Cleavable Prodrugs
… carrying electron-rich benzyl groups as a photocage, which would be oxidised by a photocatalyst with molecular oxygen as a terminal oxidant. It was found that only sufficiently electron-rich benzyl groups underwent efficient photooxidative cleavage, and in particular the 2,4-dimethoxybenzyl …
-
Drug Delivery Strategies Using Light Sensitive Molecules
… PDT, we developed a new prodrug concept called ‘Photocaged Permeability’ in our first project, and demonstrated drug delivery using this approach. The basis of this concept is that, by attaching a hydrophilic molecule to the drug via a photosensitive linker, the permeability of the drug could be …
-
Light-induced modulation of DNA recognition by the Rad4/XPC damage sensor protein.
How various macromolecules come together to form specific biological complexes and how the assembly/disassembly of such complexes are regulated are key to understanding any biological process. Characterization of such dynamical processes is challenging as it necessitates means to rapidly and …