Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Photoaffinity Pulldown"”.
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Synthetic Studies Of Biologically Active Molecules: Irl 2500, Bruceantin, And Biliatresone
… have been designed and synthesized for use in a photoaffinity pulldown experiment. The best analog has been shown to cause the biliary atresia phenotype in zebrafish and has been used in experiments aimed at determining the molecular target of biliatresone. Future study and determination of the …
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Mechanistic and therapeutic evaluation of a novel antiantiogenic small molecule
… vivo, suggesting a VEGFindependent mechanism. By photoaffinity pulldown, I identified soluble epoxide hydrolase (sEH) as an SH-11037-binding target. sEH is a key enzyme in ω-3 and ω-6 fatty acid metabolism. sEH levels were dramatically upregulated in retinal sections from L-CNV mice and a specific …
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The molecular mechanism of action of the antiangiogenic natural product, cremastranone
… protein partner of cremastranone using photoaffinity chromatography. Hence, I hypothesized that cremastranone exerts its antiangiogenic activities through modulation of the functions of FECH. Cremastranone inhibited the enzymatic activity FECH in endothelial cells. Therefore, I …