Global ETD Search
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Showing 1 to 2 of 2 for “"Photo affinity probe"”.
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Design and Synthesis of Small-Molecule Protein-Protein Interaction Antagonists
… the design and synthesis of small molecules to probe a proteinprotein interaction in a voltage-gated Ca2+ channel. Virtual screening identified a compound (BTT-3) that contained a 3,4-dihydro-3,4’-pyrazole core. This compound had modest biological activity when tested in a fluorescence …
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Antimalarial Agents: New Mechanisms of Actions for Old and New Drugs
… endocytosis. After this observation, a number of photo-affinity probes were designed and synthesized in hopes of isolating the molecular target of MQ. These analogs are currently being used by Dr. Klemba in pull-down experiments. In the third project, conducted in collaboration with Professor …