Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Phosphorylcholine"”.
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SERUM ANTI-PHOSPHORYLCHOLINE AND ANTI-CARDIOLIPIN CONCENTRATIONS FOLLOWING PERIODONTAL SCALING AND ROOT PLANING
… directed against bacterial antigens such as phosphorylcholine (PC) and cardiolipin (CL) show opsonizing cross-reactivity with oxLDL it can be proposed that there is a link between immune responses to periodontal bacteria and atherosclerosis. The aim of this investigation was to determine …
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1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine (Platelet Activating Factor): Interactions with Sheep Platelets
<p>Platelet Activating Factor (PAF) seems to link platelet function with allergy and inflammation. Early events associated with the action of PAF on platelets are poorly understood, but PAF appears to interact with a platelet membrane receptor. Two photoaffinity-labelling analogs of PAF, …
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Effect of phosphorylcholine-based small molecule analogues of the immunomodulatory nematode product ES-62 on mast cell function
ES-62, a phosphorylcholine (PC)-containg glycoprotein derived from the filarial nematode Acanthocheilonema viteae has a plethora of immunomodulatory properties. By virue of its PC moieties ES-62 has been shown to be anti-inflammatory in nature having the ability to reduce arthritis and asthma in …
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The Molecular Characterization of Phosphorylcholine (ChoP) on Histophilus somni Lipooligosaccharide: Contribution of ChoP to Bacterial Virulence and Pathogenesis
… variation of lipooligosaccharide (LOS). Phosphorylcholine (ChoP) is often expressed on H. somni LOS and also undergoes antigenic variation. In this study, five genes that play a role in expression and antigenic variation of ChoP, lic1ABCD and glpQ, were identified in the genome sequence …
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Immunomodulatory effects of the filarial nematode product, ES-62, and phosphorylcholine-based small molecule analogues S3 and S5 in experimental autoimmune encephalomyelitis
Background: Multiple sclerosis (MS) is an autoimmune inflammatory disease of which the pathophysiology includes pro-inflammatory responses of CD4+ T cells and macrophages and their associated cytokine cells with episodes of demyelination. The filarial nematode excretory secretory product ES-62 has …
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Η TETRAHYMENA PYRIFORMIS ΣΑΝ ΒΙΟΧΗΜΙΚΟ ΣΥΣΤΗΜΑ ΜΕΛΕΤΗΣ ΤΩΝ ΔΡΑΣΕΩΝ ΚΑΙ ΤΗΣ ΠΑΡΑΓΩΓΗΣ ΤΟΥ ΠΑΡΑΓΟΝΤΑ ΕΝΕΡΓΟΠΟΙΗΣΗΣ ΑΙΜΟΠΕΤΑΛΙΩΝ
… DRASTIC DECREASE OF THE 1-0-ALKYL-5N-GLYCERYL-3-PHOSPHORYLCHOLINE CONTENT OF THE PROTOZOAN LIPIDS. TETRAHYMENA PYRIFORMIS BIOSYNTHESIZES PAF WITHOUT STIMULATION WITH CA++ IONOPHORE A23187 OR ZYMOZAN. TAKE ABSENCE OF CA++ DOES NOT EFFECT PAF PRODUCTION. BOVINE SERUM ALBOUMIN IN THE INCUBATION …
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Immunomodulatory effect of the Acanthocheilonema viteae product ES-62 in arthropod extract models of asthma
… the second model employed, HDME allergy, phosphorylcholine-specific IgM antibodies were produced in the presence of ES-62 in combination with HDME but not HDME alone. ES-62 lacked efficacy in this model, though further work should be undertaken to investigate dosage alterations before …
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Molecular characterization of a sphingomyelin binding site in the vacuolating cytotoxin of H. pylori
… site exhibited sequence homology with the phosphorylcholine binding site of another SM-binding toxin. In this study we tested the effects of mutating each of the 11 tryptophan residues in VacA. While mutating each of the 8 tryptophan residues present in the auto-transporter p33 domain did …
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Comparative and Functional Genomic Studies of Histophilus somni (Haemophilus somnus)
… a prominent biofilm and that luxS as well as phosphorylcholine expression can influence biofilm formation by H. somni. In conclusion, comparative analyses of the genomes and functional characterization of putative genes have shed new light on the versatility and evolution of H. somni.
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Nanomechanical properties of hydrated organic thin films
… model system was the biologically relevant phosphorylcholine(PC)-supported lipid layer which mimics the structure of the cell membrane. The objective of this doctoral thesis was to quantify the functional form of the net surface interaction (force versus separation distance, F(D)), as well …
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The effect of small molecule analogues of the immunomodulatory helminth product ES-62 on denritic cell responses
… responses. The post-translational addition of phosphorylcholine (PC) is responsible for many of the immunomodulatory properties of this molecule and as ES-62 is potentially immunogenic, and therefore unsuitable as a drug, a library of small molecule analogues (SMAs) of ES-62 based on its PC …
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IL-25 and B cells in atherosclerosis
… the increase of IgM antibodies targeting phosphorylcholine (PC), a major epitope on oxidized LDL (oxLDL) via innate lymphoid cell type 2 (ILC2)-derived IL-5. We suggest that the essential trigger for this mechanism is the expansion of ILC2s. Additionally, blockade of endogenous IL-25 at …
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Autoimmune Responses to Atherosclerotic Lipids: A Study In Murine Models of Atherosclerosis and Obesity
… 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine by oxidization, 1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine (PGPC) is v commonly found in atherosclerotic plaques. Upon stimulation with PGPC, spleen-derived CD1d-restricted T cells produced higher levels of cytokines and …
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Novel functionalised biodegradable polymeric micro- and nano-structures for tissue engineering and drug delivery applications
… Chapter Two, one poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) and three poly(oligo(ethylene glycol)methacrylate)) (POEGMA) homopolymers were prepared using RAFT polymerisation. Two of the POEGMA homopolymers were prepared using two different functional groups, disulphide and …
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Development of a chemical biology approach for glycoprotein discovery in Caenorhabditis elegans reveals glycosylated isoforms of multiple proteins with mitochondrial function
… lab adapted this approach for the discovery of phosphorylcholine modified N-linked glycoproteins in C. elegans (Appendix A). Thus we believe that azido-substrate metabolic labeling of primary embryonic cells from the relevant <italic>C. elegans</italic> mutants will be broadly useful as a method …
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Intestinal macrophages in health and inflammation
… Chapter 7, I treated colitic mice with ES-62, a phosphorylcholine (PC)-containing glycoprotein secreted by the filarial nematode, Acanthocheilonema viteae, which has been shown to modulate pro-inflammatory cytokine production by mφ in vitro. ES-62 treatment had no significant effect on weight …
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Characterisation of the anti-inflammatory potential of ES-62 in autoimmune disease
… protect the parasite from elimination. ES-62, a phosphorylcholine-containing glycoprotein secreted by the rodent filarial nematode, Acanthocheilonema viteae, has previously been shown to modulate the responses of several innate cells to promote anti-inflammatory immune responses in vitro and in …
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Biochemistry in healthy and neoplastic human tissues: metabolic alteration revealed by HR-MAS nuclear magnetic resonance spectroscopy
… by LCModel of the resonances from choline (Cho), phosphorylcholine (PC) and glycerolphorylcholine (GPC), the three main components of the combined tCho peak observed in gliomas by in vivo 1H MRS spectroscopy. All glioma biopsies depicted an increase in tCho as calculated from the addition of Cho, …