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Showing 1 to 20 of 2185 for “"Phosphorylation"”.
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Protein Phosphorylation in Archaea
Protein phosphorylation constitutes an important mechanism for cellular regulation in both Eucarya and Bacteria. All living organisms evolved from a common progenitor; this implies that protein phosphorylation as a means of regulation also exists in Archaea. Previously, in the sulfur-dependent …
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Protein phosphorylation regulation in Arabidopsis
… OF MISSOURI AT AUTHOR'S REQUEST.] Protein phosphorylation and dephosphorylation are fundamental mechanisms involved in many cell-signaling events. Coordinated actions of protein kinases and protein phosphatases help maintain the signaling through reversible protein phosphorylation and …
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Phosphorylation Regulation of T-Lymphocyte Migration
… protein L-plastin, through the process of phosphorylation. Theregulation of Myosin-IIA enables it to generate contractile force inside a migrating T-cell, maintaining the shape and proper adhesion of the cell to extracellular matrix, both being requirements for successful migration. The …
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Regulation of Myo5p function by phosphorylation
… the myosin-I ATPase. This work demonstrates that phosphorylation of the Myo5p TEDS site is required for two myosin-I in vivo functions in yeast, endocytosis and actin cytoskeleton polarization. However, the yeast PAKs Ste20p, Cla4p and Skm1p and their activator Cdc42p, while important for actin …
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MECHANISM OF PINK1-MEDIATED UBIQUITIN PHOSPHORYLATION
Ubiquitin phosphorylation by PINK1 (PTEN-induced Putative Kinase 1) is crucial for mitochondrial quality control and loss or mutation of PINK1 can lead to autosomal recessive juvenile parkinsonism (AR-JP). PINK1 is an unusual kinase, as it is characterised by three unique insertions in its kinase N …
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The Regulation of Phosphorylation Events in Platelets
… of ADP receptors. These studies have shown MLC phosphorylation occurs rapidly and is essential for shape change following the stimulation of ADP receptors. Technological advances in antibody development have resulted in the generation of commercially available phospho-specific antibodies for MLC …
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The Mycobacterium tuberculosis protein O-phosphorylation landscape
Protein phosphorylation is a main mechanism for translating extracellular signals into cellular adaptations. In bacteria, the two-component system has been the paradigm of protein phosphorylation. Increasingly, however, protein serine/threonine and tyrosine phosphorylation (O-phosphorylation) …
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Metabolic Regulation of Protein Phosphorylation and Acetylation
Pages i-xviii are misnumbered in a variety of ways.
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Ezh2 T416 Phosphorylation Enhances Breast Cancer Tumorigenesis
… these TIC populations is yet to be elucidated. Phosphorylation of EZH2 by cyclin dependent kinases (CDK) has been reported to control EZH2 epigenetic function and thus consequently control cancer cell proliferation, invasion, and stem cell differentiation. Our group has established that EZH2 and …
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Examining Intracellular Phosphorylation Gradients During Cell Division
… at two different levels. First, I analyze a phosphorylation gradient for substrates of the chromosomal passenger complex (CPC). CPC is a conserved regulator involved in key mitotic events such as chromosome-microtubule attachment and spindle midzone formation. Previously, spatial …
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Phosphorylation of polyglycans, especially glycogen and starch
… enzymes. In Arabidopsis insufficiency in starch phosphorylation or dephosphorylation results in largely impaired starch turnover, starch accumulation, and often in retardation of growth. In humans the progressive neurodegenerative epilepsy, Lafora disease, is the result of a defective enzyme …
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Regulation of HPr phosphorylation in Mycoplasma pneumoniae
Das Genom des Mollicuten Mycoplasma pneumoniae enthält lediglich 688 Gene. Zu den wenigen erhalten gebliebenen Proteinen mit regulatorischer Funktion gehört die HPr-Kinase/Phosphorylase (HPrK/P) aus dem Phosphoenolpyruvat:Zucker-Phosphotransferase-System. In dieser Arbeit wurde das in vivo …
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Interphase phosphorylation of H1.4 in transcriptional control
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2020-12-01
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Engineering phosphorylation-dependent post-translational protein devices
One goal underlying synthetic biology is to develop standard biological parts that can be reliably assembled into devices encoding higher-order functions. Here, I developed a framework for engineering post-translational devices, which are devices whose inner workings are modulated by non-covalent …
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Phosphorylation based insulation devices design and implementation
This thesis presents the analysis of a phosphorylation based insulation device implemented in Saccharomyces cerevisae and the minimization of the retroactivity to the input and retroactivity to the output of a single cycle phosphorylation device by means of optimal substrate and phosphatase …
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Post-translational phosphorylation dynamics in Arabidopsis and Physcomitrella
Phosphorylation is the most abundant post-translational modification that involves the chemical addition of a phosphate group onto serine, threonine, or tyrosine residues of substrate proteins. Phosphorylation is utilized to regulate protein activity, stability, or localization to respond to …
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Role of Phosphorylation In The Regulation of Prmt5
… which prompted us to investigate whether phosphorylation of PRMT5 regulates its subcellular localization and/or substrate choice, by facilitating phospho-dependent protein-protein interactions.</p> <p>To study how phosphorylation affects PRMT5 function, protein microarrays were used to …
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Molecular Characterization of Dopamine Transporter Phosphorylation and Regulation
… blocking reuptake or by inducing DA efflux. DAT phosphorylation and transport down regulation are best demonstrated with the treatment of Protein kinase C (PKC) activators such as (phorbol 12-myristate 13-acetate) PMA. Serine(s) and threonine(s) are known to be involved in DAT …
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