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Showing 1 to 20 of 65 for “"Phosphoryl"”.
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Bioinspired Catalysts for Phosphoryl Transfer Reactions
Phosphoryl transfer reactions are ubiquitous in biology and are usually catalyzed by metalloenzymes. For a number of phosphoryltransfer enzymes, including the exonuclease subunit of DNA polymerase I, a mechanism involving two metal ions and double Lewis-acid activation of the substrate, combined …
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Synthesis and characterisation of novel α-functionalised phosphoryl derivatives
This thesis focuses on the synthesis and study of α-aminoalkylphosphinic acids, α-aminoalkylphosphonic acids and macrocycles containing these sub-units. There are two broad types of macrocyclic systems that are targeted: (i) C-functionalised α-aminophosphonic acids; and (ii) N-functionalised …
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Phosphoryl-Coenzyme A, an Intermediate in Enzymatic Succinylation of Dihydrolipoic Acid
Made available in DSpace on 2015-05-12T17:02:37Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 0025286.PDF: 2989149 bytes, checksum: 555c748895855dbf1e4be9b513ad4dbc (MD5) Previous issue date: 1957
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Enzyme-Catalyzed Phosphoryl Transfer Reactions: Energetics of Transition States and Vanadate Analogues in Aqueous Solution
… of biochemical processes. The transfer of phosphoryl groups is a ubiquitous process in living organisms that drives key cellular activities such as glycolysis and DNA replication. Vanadate is recognized as an effective structural and electronic analogue of phosphate. Solvation effects are …
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Molecular basis of the evolution of new protein functions: Kemp elimination and phosphoryl transfer reactions
This is a series of investigations into the molecular basis of the evolution of new protein functions. The broad objective of this work was to determine exactly how a series of single amino acid mutations, typical of an evolutionary trajectory, can result in dramatic changes in catalytic activity, …
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Molecular basis of the evolution of new protein functions: Kemp elimination and phosphoryl transfer reactions
This is a series of investigations into the molecular basis of the evolution of new protein functions. The broad objective of this work was to determine exactly how a series of single amino acid mutations, typical of an evolutionary trajectory, can result in dramatic changes in catalytic activity, …
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X-ray crystallographic studies of the nucleotide binding sites on adenylosuccinate synthetase mutants from Escherichia coli
… structures presented in this work contain 6-phosphoryl-IMP, GDP, and Mg⁺². The K 16Q and R 143 L mutants have hadacidin bound, whereas R3 03 L has only water molecules in the putative aspartate binding site. As a consequence the 300's loop is disordered in the R3 03 L structure. In the K 16Q …
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Reactivity studies of phosphoric amides and esters
… interpreted in terms of the interaction of the phosphoryl oxygen atom with Lewis acids and oxygen/nitrogen diprotonation in trifluoromethanesulphonic acid. Intramolecular nucleophilic displacement of the halide ion from secondary β-chloroethyl-substituted phosphoramidates X₂P(O)NHCH₂CH₂Cl, …
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Structure and substrate specificity of myo-inositol phosphatases at atomic resolution
… (PTPLPs) follow an ordered, sequential dephosphorylation pathway that utilizes the abundant myo-inositol- 1,2,3,4,5,6-hexakisphosphate (InsP6) to produce less-phosphorylated myo-inositol phosphates (IPs) containing between one and five phosphoryl groups. To understand PTPLP substrate …
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Investigations into the chemistry of protein tyrosine phosphatase redox regulation
… is often accomplished through the reversible phosphorylation of specific protein tyrosine residues. This reversible phosphorylation serves as a biochemical "rheostat" that alters a protein's functional properties and leads to propagation of the signal. The phosphorylation status of these …
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Going Beyond Phosphorylation: Acetylphosphate-Mediated Ran Polymerase Acetylation and Caper Phosphorylation Co-Regulate Transcription of Escherichia Coli Stress-Responsive Gene cpxP
… to the interior of the cell via a transfer of phosphoryl groups from the sensory protein know as sensor kinase (SK) to the output protein known as response regulator (RR).</p><p>In addition to this constant input of extracellular information, bacterial cells also monitor their intracellular …
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Organization and dynamics of the bacteriophage Mu transpososome
… set of spatially and temporally coordinated DNA phosphoryl transfer reactions to move the element from an existing DNA location to a new DNA site. The Mu transpososome, where the DNA cleavage and joining reactions that compose transposition take place, is a large nucleoprotein complex containing …
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Synthesis and reactivity of early transitional metal complexes supported by sterically demanding amido ligands
… 3: Synthesis and Reactivity of a Linear Terminal Phosphoryl (PO) Ligand -- Chapter 6: Molybdenum Complexes of an Amido Ligand Containing a -Hydrogen Atom.
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Use of Bioinformatics in the Analysis of Chemotaxis Proteins
… to the excitation pathway via the transfer of a phosphoryl group from the receptor-associated histidine kinase CheA to the response regulator CheY. Phospho-CheY binds to the flagellar motor switching the direction of rotation of the flagella and thus allowing the cell to move towards or away from …
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Ultrahigh Vacuum Studies of the Fundamental Interactions of Chemical Warfare Agents and Their Simulants with Amorphous Silica
… the formation of a hydrogen bond between the phosphoryl oxygen of the simulant and an isolated hydroxyl group on the surface. In the limit of zero coverage, and after defect effects were excluded, the activation energies for desorption were measured to be 57.9 ± 1, 54.5 ± 0.3, 52.4 ± 0.6, 48.4 …
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Mechanistic studies to determine the catalytic roles of active site residues in phosphite dehydrogenase
… NADH. The mechanism of the reaction resembles a phosphoryl transfer reaction. A nucleophilic displacement reaction occurs on the phosphoryl group, with water or hydroxide attacking the phosphorus atom and hydride acting as the leaving group. Given the inherently poor nature of the hydride leaving …
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Chemical Probes and Strategies to Study Mycobacterial Cell Envelope Assembly
… the development of azido-functionalized farnesyl phosphoryl mannose (AzFPM) probes that mimic native polyprenyl-phosphoryl donors and selectively label mannose-containing glycolipids in live mycobacteria. Chapter 3 showcases how these probes enable glycan substructure-specific labeling and …
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