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Showing 1 to 9 of 9 for “"Phosphoramidates"”.
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The synthesis and fungicidal activity of some novel phosphoramidates
The synthesis of novel fungicidal phosphoramidates was the main objective of the present work. Various fungitoxic substituents were included in their structure together with a trichloromethyl group which has been shown to enhance fungicidal activity in other compounds. Fourteen compounds containing …
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Dimethyl N-Aryl phosphoramidates : structural effects on bonding and solvolytic reactivity
… number of ring alkyl substituted dimethyl N-aryl phosphoramidates, (MeO)2P(0)NHAr, has been studied by measuring the rates of hyd~olysis with the aid of a UV spectrophotometer. These rates have been correlated with the pKa values of the corresponding ani I inium iOhs and the slope of this …
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Tertiary N-acyl phosphoramidates : a mechanistic study of their formation and collapse in reactions with nucleophiles
… The preparation of (III) via the N-acylation of phosphoramidates was investigated. The reaction of PhC(O)X (X = Br, Cl, F) with the conjugate base of (EtO)₂P(O)NHMe (IX) yields three products: PhCO₂Et (4), PhC(O)NHMe (5) and (PhCO)₂NMe (6). (5) and (6) are formed via the initial rapid formation …
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Development of chemical probes for intracellular nucleotide delivery, profiling of the metabolic fate(s) of nucleoside monoester phosphoramidates, and a nucleotide mimetic inhibitor of eIF4E
… interacting partners of nucleoside monoester phosphoramidates. Mapping the small molecule-protein interactome of nucleoside monoester phosphoramidates should help us decipher the mode of cellular uptake and identify other metabolizing enzymes of nucleoside monoester phosphoramidates (excluding …
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Reactivity studies of phosphoric amides and esters
… shifts of the ester and amide bonds in selected phosphoramidates (RO)₂P(O)NR'₂ was investigated. The results are interpreted in terms of the interaction of the phosphoryl oxygen atom with Lewis acids and oxygen/nitrogen diprotonation in trifluoromethanesulphonic acid. Intramolecular nucleophilic …
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CHIRAL LEWIS BASES ACTIVATION OF TRICHLOROSILYL DERIVATIVES
… three class of compounds: phosphoramides, phosphoramidates and phosphine oxides. These compounds, in presence of trichlorosilyl derivatives, generate hypervalent cationic species able to promote stereoselective C-H bond formations (by reaction with HSiCl3) and stereoselective C-C bond …
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Carbonyl Catalysis: Hydrolysis of Organophosphorus Compounds and Application in Prebiotic Chemistry
… proved efficient with phosphinic amides and phosphoramidates. Moreover, chemoselectivity was also studied and selective hydrolysis of the P(=O)-N bonds in the presence of P(=O)-OR bonds could be accomplished. The second part of this thesis demonstrated the further development of one of the …
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A structure-reactivity study of selected phosphorus compounds
… a series of ring substituted dimethyl-N-phenyl-phosphoramidates, (R)PhNHP(OCH₃)₂, (R = p-OMe, H, p-NO₂, o-Et and 2,6-diMe) have confirmed the preference of the phosphoramidates for dimer formation which was proposed earlier from infrared data. The formation of N - H - - - - O = P hydrogen bonded …