Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Phosphoramidate"”.
-
Development of chemical probes for intracellular nucleotide delivery, profiling of the metabolic fate(s) of nucleoside monoester phosphoramidates, and a nucleotide mimetic inhibitor of eIF4E
… successful application of the aryloxy amino acid phosphoramidate (ProTide) strategy for development of sofosbuvir. Although widely successful, several drawbacks of the ProTide strategy limit its utility for delivery of significant levels of nucleotide analogs in tissues other than the liver. In …
-
The synthesis and fungicidal activity of some novel phosphoramidates
The synthesis of novel fungicidal phosphoramidates was the main objective of the present work. Various fungitoxic substituents were included in their structure together with a trichloromethyl group which has been shown to enhance fungicidal activity in other compounds. Fourteen compounds containing …
-
Dimethyl N-Aryl phosphoramidates : structural effects on bonding and solvolytic reactivity
… number of ring alkyl substituted dimethyl N-aryl phosphoramidates, (MeO)2P(0)NHAr, has been studied by measuring the rates of hyd~olysis with the aid of a UV spectrophotometer. These rates have been correlated with the pKa values of the corresponding ani I inium iOhs and the slope of this …
-
Advancements in the synthesis of distorted tricoordinate phosphorus compounds and their use as platforms in reductive chemistries
… phosphines. Chapter three presents a distorted phosphoramidate with a functionally hydridic P-H bond derived from the activation of water to generate equivalents of hydrogen. Chapter four explores the activation of both hydrazine and hydrazones by a distorted phosphoramidite and initial results …
-
Rapid, Efficient and Versatile Strategies for Functionally Sophisticated Polymers and Nanoparticles: Degradable Polyphosphoesters and Anisotropic Distribution of Chemical Functionalities
… addition, a direct synthesis of acid-labile polyphosphoramidate by organobase-catalyzed ring-opening polymerization and an improved two-step preparation of polyphosphoester ionomer by acid-assisted cleavage of phosphoramidate bonds on polyphosphoramidate were developed. Polyphosphoramidate and …
-
Carbonyl Catalysis: Hydrolysis of Organophosphorus Compounds and Application in Prebiotic Chemistry
… the hydrolysis of one inorganic substance, phosphoramidate. This Chapter describes a systematic research to identify a superior catalyst, o-phthalaldehyde, and develop catalytic hydrolyses of various organophosphorus compounds containing P(=O)-NHR subunits. Gratifyingly, the reaction proved …
-
Localization and Function Of RNA Interference in the Cerebral Cortex
… retention in tissues. The advantage of EDC-based phosphoramidate-linked miRNA is that the sample can be exposed to higher temperatures for a longer time, resulting in a more complete reversion of the formaldehyde induced nucleobase modification of the miRNAs and less interference with probe …
-
DNA catalysts for amide bond cleavage and for lysine side chain modification
… identified which catalyze the reaction between phosphoramidate linkage and triphosphorylated RNA, even when a much stronger lysine nucleophile was available. In efforts described in chapter 4, a more reactive phosphorimidazolide substrate was employed to react with both DNA-C3-NH2 and …