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Showing 1 to 19 of 19 for “"Phosphonic acids"”.
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Nitrogen Compounds of the Phosphoric and Phosphonic Acids
Made available in DSpace on 2014-12-05T19:35:59Z (GMT). No. of bitstreams: 1 0009145.pdf: 6317038 bytes, checksum: 189e69dc53192acb9a665a1bd8f42394 (MD5) Previous issue date: 1954
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Pathway engineering for the discovery and optimized production of phosphonic acids
… a focus on the class of natural products called phosphonic acids. These compounds have a stable carbon-phosphorus bond, which allow them to mimic phosphate esters and carboxylic acids, making them potential enzyme inhibitors. For the antimalarial phosphonate FR900098, a novel pathway engineering …
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The synthesis, structure and fungicidal activity of guanidinophosphonic acids and their aminophosphonic precursors
Alkanephosphonic acids of the classes a-amino, a-guanidino, a-(hydroxy)amino, a-thioureido, w-amino, and w-guanidino have been prepared, and also the u-amino and 10-guanidino types having aza substituents In positions 2 and 3 In the alkyl chain. The 1H, 13C, and 31p nmr spectroscopy of these …
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Design and synthesis of novel P. fulciparum GDH inhibitors for use as potential antimalarial agents
… phosphonates, substituted benzyl-α-hydroxy phosphonic acids and substituted benzyl-α-amino phosphonic acids. These compounds are intended to target one of the recently hypothesised antimalarial drug development targets, Pf-glutamate dehydrogenase (PfGDH). 2) The synthesised compounds were …
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Synthesis of phosphorus/sulfur-based antivirals
… derivatisation of adefovir via the corresponding phosphonic dichloride intermediate and under Garegg-Samuelsson reaction conditions is further discussed. The preparation of novel butyl and dibutyl phosphonate analogues of adefovir using both approaches is described. Attempted coupling of the …
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Synthesis of Chiral Vanadium Phosphonates and Their Catalytic Activity
… starting materials with chiral and achiral phosphonic acids and phosphonates provided the soluble [BuPPh3]4[(V 2O2(OH)2)6(O3PR)8] R = CH(CH2Ph)Pr and CH(Et)Pr, [(VO)6(O3PR) 8{Cl}] R = CH2Ph, CHMePh-S, and [(V 14O22)(OH)4(O3PR)8] 6- with R = CHEtPr, CH(CH2Ph)Pr, and CH(Me)Ph- S cage …
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Block and Graft Copolymers Containing Carboxylate or Phosphonate Anions
… Binding capabilities of the acrylamide phosphonic acids were investigated through interactions with hydroxyapatite. Previously our group has prepared poly(ethylene oxide)-b-poly(acrylic acid) (PEO-b-PAA) copolymers and used these polymers as carriers for both MRI imaging agents and …
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Investigation of Biotransformation of 6:6 PFPiA into C6 PFPA during Anaerobic Digestion of Sludge
… of perfluorinated phosphinic and phosphonic acids (PFPiAs & PFPAs) have been studied in animal and plant models, but not in wastewater treatment plant sludge. This is concerning since the toxicity and general research into PFPiAs and PFPAs is lacking and biosolids, a by-product of …
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Novel acyclic nucleotide phosphonates against RNA viruses
… was then deprotected to their corresponding phosphonic acids via a bromotrimethylsilane mediated phosphonate ester hydrolysis. In one example, a bis(pivaloyloxymethyl) prodrug variant was produced in order to probe a general synthesis for prodrug protected ANP derivatives. All new compounds …
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Synthesis and Characterization of Pyrrole Based Adhesion Promoter Systems on Oxide Substrates
… oxidized surfaces, 3-substituted pyrrole alkyl phosphonic acids, 11-(pyrrol-3-yl undecyl) trimethoxysilanes and 1-substituted pyrrole alkyl organosilanes with different chain length were designed and successfully synthesized as adhesion promoters. These new derivatives were studied for their …
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Chiral phosphonyl and thiophosphonyl carbanions in asymmetric alkylation and olefination reactions
… which allowed the preparation of scalemic phosphonic acids and phosphonates with three $\alpha$-substitution patterns (aryl, alkyl, and alkoxy). Synthesis of $\alpha$-hydroxyphosphonates in either antipodal form could be achieved by the highly diastereoselective alkylation of anions derived …
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Synthesis and structural analysis of [alpha]-aminophosphonic acids and their phosphonate ester derivatives
… and characterisation of novel [alpha]-aminophosphonic acids and their phosphonate ester derivatives. Compounds of these types are of interest because of their potential for biological activity, particularly in the area of agricultural chemistry. The second objective was to investigate the …
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On the coordination chemistry of pentavalent (σ⁴, λ⁵) phosphorus compounds
… asymmetric synthesis of enantiopure α-alkylbenzylphosphonic acids, and the use of these compounds to prepare homochiral vanadium diphosphonate materials that can serve as heterogeneous catalysts for the asymmetric epoxidation of allylic alcohols, and (2) the design and synthesis of novel …
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Targeting isoprenoid biosynthesis for drug discovery
… structurally diverse compounds (benzoic/diketo/phosphonic acids, bisamidine, and bisamine) that inhibit UPPS, an essential enzyme involved in cell wall biosynthesis. The inhibitors bind to one or more of the four inhibitor-binding sites with the most active leads binding to site-4, not the …
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Separation of alkali metal cations and alkaline earth cations using ionizable crown ethers
… A series of novel crown ether carboxylic acids , crown ether phosphonic acid monoesters, and crown ether phosphonic acids which possess lipophilic pendant groups were employed for the study of extraction and membrane transport. In addition to mono- and di-ionizable macrocyclic complexing …
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Oxygen-dependent enzymes involved in phosphonate biosynthesis
… Among the most useful natural products are the phosphonic acids, which contain a carbon-phosphorus bond. Over the years, these small molecules have shown great success as drugs and herbicidal compounds, thus it is prudent to facilitate the rapid discovery and characterization of new phosphonate …
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Synthesis and Characterization of Thin films of Novel Functionalised 2,5-Dithienylpyrrole Derivatives on Oxide Substrates
… based monomers, 3-phenyl N-alkyl pyrrolyl phosphonic acids referred as C10PhP and C12PhP and the monomers based on 2,5-dithienylpyrrole were synthesized with different anchoring groups namely, -Si(OMe)3 and-PO3H2 and spacer groups (n= 4, 6, 10, 12, benzyl). SNSnP for …
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Synthesis and characterisation of novel ferrocenyl compounds
… with diethyl phosphite. The ferrocenyl phosphonic acids FcP(O)(OH)₂ 3, FcCH₂P(O)(OH)₂ 4, FcCH₂CH₂P(O)(OH)₂ 5, 1,1'-Fc' [P(O)(OH)₂]₂ 6 and 1,1'-Fc'[CH₂P(O)(OH)₂]₂ 7 were synthesised by hydrolysis of the corresponding phosphonate esters. X-ray crystal structure determinations were carried …