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Showing 1 to 20 of 67 for “"Phosphonates"”.
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Functional Metal Phosphonates
… the incorporation of functionality into metal phosphonates. This was done in one of several ways. The first involved using phosphonate ligands that had covalently attached organic functional groups. In some cases, these ligands undergo reactions during the solvothermal syntheses which can …
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Novel acyclic nucleotide phosphonates against RNA viruses
Acyclic nucleotide phosphonates (ANPs) have been used for years as successful anti-viral agents against diseases such as HIV/AIDS and hepatitis while the drug ribavirin is one of the only drugs available for the treatment of RNA-viral infections which mainly affect the developing world. The large …
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Synthesis of Chiral Vanadium Phosphonates and Their Catalytic Activity
… with chiral and achiral phosphonic acids and phosphonates provided the soluble [BuPPh3]4[(V 2O2(OH)2)6(O3PR)8] R = CH(CH2Ph)Pr and CH(Et)Pr, [(VO)6(O3PR) 8{Cl}] R = CH2Ph, CHMePh-S, and [(V 14O22)(OH)4(O3PR)8] 6- with R = CHEtPr, CH(CH2Ph)Pr, and CH(Me)Ph- S cage complexes. These are the first …
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Synthesis and Characterization of Mixed-Metal Phosphonates For Polymer Dielectric Composite Materials
… converted into novel layered mixed metal organophosphonates through hydrothermal or melt methods. The zur Loye group has been interested in preparing polymer dielectric composites. A new series of mixed metal organophosphonates (AB(RPO3)3) were synthesized, fully characterized, and incorporated …
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Towards decomposition of phosphonates in water using catalytic membranes: paraquat on silica as a proxy
… to the effective treatment of wastewater with phosphonates and ensure subsequent removal of degradation by-products. The focus of this MSc thesis is to conduct a feasibility study of using silica supported catalysts as membrane materials to treat wastewater containing phosphonates. Because …
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Study of the reaction of nitriles with dialkyl phosphites for synthesis of a-Amino-bis-phosphonates
<p>Amino bisphosphonate compounds are found in a vast array of products from water chelators to flame retardants to pharmaceuticals. Previous methods to synthesize these compounds involved the use of protic acids, which don’t provide ideal conditions for the starting materials containing acid …
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Synthesis and kinetic studies of tricyclic phosphates and phosphonates: Effect of phosphorus-oxide stereochemistry on allylic rearrangements
… studies are reported on tricyclic phosphates and phosphonates which were prepared from 11 and 12 step syntheses. First order rate constants for solvolysis (k$\sb{\rm s}$) and loss of optical activity (k$\sb\alpha$) were measured for 12a and 12b under solvolytic conditions (30% D$\sb2$O/70% …
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Exploring the interaction between asymmetric phosphonates and acetylcholinesterase. Probing the gorge and P-site via customized covalent modification
<P>Organophosphates (OPs) react with acetylcholinesterases (AChEs) to form a covalent bond at a specific serine residue in the active gorge, thereby providing a highly precise modification of this enzyme and an opportunity to explore protein structure, function and mechanism. The goal of this study …
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Exploring the interaction between asymmetric phosphonates and acetylcholinesterase. Probing the gorge and P-site via customized covalent modification
<P>Organophosphates (OPs) react with acetylcholinesterases (AChEs) to form a covalent bond at a specific serine residue in the active gorge, thereby providing a highly precise modification of this enzyme and an opportunity to explore protein structure, function and mechanism. The goal of this study …
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Phosphonate biogeochemical cycling in the marine environment: from an ocean scale to a molecular scale
… (P) redox cycle was recently confirmed when phosphonates, organophosphorus compounds with P in the (III) oxidation state, were found in high molecular weight dissolved organic matter. Although some features of the P redox cycle have come to light since the discovery of phosphonates, many …
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Phosphonate biogeochemical cycling in the marine environment: from an ocean scale to a molecular scale
… (P) redox cycle was recently confirmed when phosphonates, organophosphorus compounds with P in the (III) oxidation state, were found in high molecular weight dissolved organic matter. Although some features of the P redox cycle have come to light since the discovery of phosphonates, many …
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Developments in Analytical Chemistry: Acoustically Levitated Drop Reactors for Enzyme Reaction Kinetics and Single-Walled Carbon Nanotube-Based Sensors for Detection of Toxic Organic Phosphonates
Developments in analytical chemistry were made using acoustically levitated small volumes of liquid to study enzyme reaction kinetics and by detecting volatile organic compounds in the gas phase using single-walled carbon nanotubes. Experience gained in engineering, electronics, automation, and …
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Synthesis and Structural Studies of Calcium and Magnesium Phosphinate and Phosphonate Compounds
… of magnesium and calcium based phosphinate and phosphonates with possible applications as bone scaffolding materials or additives to bone cements. The challenge to the chemistry of the alkaline earth phosphonate target compounds includes poor solubility of compounds, and poorly understood …
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Synthesis and Characterization of Polymer Composite Materials For Lithium Battery Cathodes and Capacitors
… of titanates, aluminates, and novel mixed metal phosphonates. We investigated BaTiO3 materials, covalently surface-modified BaTiO3, and novel mixed metal phosphonates, ATi(O3PC6H5)3 (A = Ba, Sr) to assess the effect of particle size and surface treatment on the composites' effective dielectric …
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Investigations of molecular recognition processes
… and $\alpha$-aryl substituted $\alpha$-amino phosphonates were prepared. The ability of several CSPs to separate the enantiomers of N-(3,5-dinitrobenzoyl) derivatives of $\alpha$-alkyl and $\alpha$-aryl substituted $\alpha$-amino phosphonates was investigated. Using the chromatographic …
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Synthesis and Chromatographic Evolution of Structurally Rigid Naproxen Analogs and Trans-3,4-Disubstituted-2,6-Piperidinediones
… evaluation of a number of (beta-aminoalkyl)phosphonates are reported.
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Molecular characterization of phosphonate biosynthesis in nature
Phosphonates, compounds characterized by direct C-P bonds, comprise a structurally diverse class of natural products demonstrating an impressive range of biological activities. Although the first biologically produced phosphonate was described more than 50 years ago, the range and diversity of …
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Investigation of the biosynthesis of the phosphonate antibiotics bialaphos and dehydrophos
… group. Since the dianionic form of phosphonates at pH 7 poses a drawback with respect to their ability to mimic carboxylates and tetrahedral intermediates, esterification of a phosphonate group by SAM-dependent methyltransferase, DhpI would provide a solution to alleviating the high …
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