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Showing 1 to 5 of 5 for “"Phosphonate biosynthesis"”.
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Molecular characterization of phosphonate biosynthesis in nature
Phosphonates, compounds characterized by direct C-P bonds, comprise a structurally diverse class of natural products demonstrating an impressive range of biological activities. Although the first biologically produced phosphonate was described more than 50 years ago, the range and diversity of …
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Oxygen-dependent enzymes involved in phosphonate biosynthesis
… us to identify the enzymes required for the biosynthesis and functionalization of these compounds and the enzymes that may be used for inactivation of toxic compounds. They also inform us on strategies that can be used to manipulate these organisms to produce derivatives of potentially useful …
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Investigation of phosphonate biosynthesis: I. Structure of dehydrophos II. Mechanism of hydroxyethylphosphonate dioxygenase
Natural product phosphonates are used extensively in the clinic as antibacterials and in commercial agriculture as herbicides. In an effort to efficiently discover new natural product phosphonates, a multidisciplinary, collaborative program has been established at the Institute for Genomic Biology …
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Mechanistic investigations of enzymes in phosphonate metabolism
Synthetic and naturally-occurring phosphonates have found widespread use in both agriculture and medicine. A program at the Institute for Genomic Biology at the University of Illinois at Urbana-Champaign was established to discover novel phosphonate natural products. In addition to this effort, the …
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Phosphonate natural products from host-associated enterobacteria
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01