Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Phospholipid bilayer"”.
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Photochemical Applications to the Study of Complexity Phospholipid Bilayer Environments
… a biological membrane model, phosphatidylcholine bilayers, were investigated using novel spiropyran/merocyanine molecular probes. The femtosecond to second dynamics of this system's photochemistry enabled bilayer viscosity and free volume to be studied over a broad time scale. …
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Investigation of Phospholipid Bilayer Interactions With Substrates, Polymers, and Nanoparticles
… to interact with and disrupt cell membranes. Bilayers composed of both neat zwitterionic lipid headgroups and cationic lipid headgroups were examined to investigate charge interactions between the lipid headgroups and negatively charged fullerene aggregates. Our results indicate that water …
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Development of a saposin A based native-like phospholipid bilayer system for NMR studies
… mimetic system. It provides a native-like lipid bilayer, high incorporation yield and more importantly size adaptability. SapA lipid nanoparticles have been applied to structural studies and two high-resolution structures of membrane proteins were previously obtained using cryo-electron …
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A DETAILED STUDY OF PROTEIN-SUPPORTED PHOSPHOLIPID BILAYER SYSTEMS AS MODEL INTERFACES TO INVESTIGATE BIOMEMBRANE INTERACTIONS
… interaction between ionic liquids and supported phospholipid bilayers by AFM. 4) Synthesis and characterization of highly conjugated heterocyclic molecules with interesting photophysical properties.
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Characterization of Monomeric Human Cytochrome P450 3A4 and Cytochrome P450 Reductase in Nanoscale Phospholipid Bilayer Discs
… The use of a discrete soluble nanoscale phospholipid bilayer system with an incorporated CYP3A4 molecule will be described here; it is this homogeneous monomeric population that will give rise to the detailed description of the differences between these systems of study. This Nanodisc …
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Microscopic and Spectroscopic Investigation Of: I. Copper-Additive Systems in Electroplating Bath. II. Supported Phospholipid Bilayer Systems
… the phase transition process of supported lipid bilayer systems with and without the influence of other macromolecules. Addition of a weak polyelectrolyte, poly(methacrylic acid) (PMA), to a supported phospholipid bilayer depresses the melting temperature and alters the morphology of the bilayer …
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Paviršiuje imobilizuotų membranų formavimosi ir sąveikos su α-hemolizinu dinamikos tyrimas greitosios Fourier transformacijos elektrocheminio impedanso spektroskopijos metodu /
Tethered bilayer membranes (tBLM) are used as models that mimic biological cell membranes. In this work, such a model was developed using a glass slide coated with fluorine-doped tin oxide (FTO), on which a phospholipid bilayer (60 % DOPC and 40 % Chol.) was immobilised via self-assembled monolayer …
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The Effect of Phospholipid Polar Head Group Supplementation on The Microsomal Cytochrome B5 System
The maintenance of a fluid phospholipid bilayer is important for a number of membrane associated functions. The fluidity of the bilayer is determined by the lipid composition. The lipid composition can be described in terms of the phospholipid polar head group composition, the fatty acid …
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Investigating lipid corona formation onto polystyrene nanoparticles through fluorescence correlation spectroscopy
… body is the cell membrane, which is composed of phospholipid bilayer. Fluorescence correlation spectroscopy (FCS) is a promising tool that can be used to probe nanoparticle-cell interactions. FCS experiments focusing on exposure of lipid vesicles to different polystyrene nanoparticles indicate …
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Regulation of The Expression and Lysine Acetylation of Pro-Inflammatory Molecules By Lipid-Modifying Enzyme (LPCAT2) in RAW264.7 Cells
… significantly regulate changes in the glycerophospholipid components of the macrophage membrane phospholipid bilayer. LPCAT2 is a subtype of LPCAT that regulates inflammatory responses to infection by lipopolysaccharides and lipopeptides. LPCAT2 co-localises with TLR4 and prevents its …
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Analyzing Functional Interactions of Designed Peptides by NMR Spectroscopy
… cyclic peptides and their linear analogs with a phospholipid bilayer mimicking a bacterial membrane was studied using nuclear magnetic resonance (NMR) spectroscopy. These results provided insight into the mechanism of peptide bactericidal action and the role of the peptide structure in their …
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Development of a novel SERS assay for the detection of MiRNA and the synthesis and use of lipid soluble nanoparticles for the application to cardiovascular disease
… particles and their ability to penetrate the phospholipid bilayer, thus demonstrating their potential to act as a biomarker detector.
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QUB-3005, a bioactive peptide from the defensive skin secretion of Rana amurensis
… of activities, for example, by disrupting the phospholipid bilayer of the target cell membrane to kill bacteria or inhibit their growth.<br/><br/>In this thesis, a bioactive peptide, named QUB-3005, was isolated using “shotgun” cloning of its biosynthetic precursor-encoding cDNA from a skin …
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Engineering spores to display g protein-coupled receptors for directed evolution
… are surrounded by a plasma membrane made from a phospholipid bilayer, which is responsible for maintaining a biologically active species, while stopping entry of deleterious substances from the outside. G protein-coupled receptors (GPCRs) are the membrane proteins, which transmit signals across …
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Investigating Cholesterol Orientation in Lipid Bilayer by Raman Spectroscopy
… of molecules ranging from different sterols to phospholipids to membrane partitioning proteins. While the overall compositions of these various elements are understood in part, how the phospholipid bilayer in cells accommodates the different processes for the copious types of proteins is not …
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The tissue factor-factor VII(a) complex in blood coagulation
… association with TF inserted in an appropriate phospholipid bilayer increases its proteolytic activity on macromolecular substrates many million-fold. The mechanisms by which TF enhances the activity of FVIIa, and the role of the membrane surface in enhancing catalysis by the TF/FVIIa complex …
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Dynamics of biological macromolecules investigated by fluorescence depolarization
… disk-like molecule, a rod-like molecule in a phospholipid bilayer, and a tryptophan residue in a protein matrix."
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Dynamics of biological macromolecules investigated by fluorescence depolarization
… disk-like molecule, a rod-like molecule in a phospholipid bilayer, and a tryptophan residue in a protein matrix."
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Structure and Application of Photosensitive Self-assembled Pseudoisocyanine J-aggregates on Membrane Surfaces
… assemble into crystals in solution, on planar bilayer templates, and on the membranes of living cells. Pseudoisocyanine J-aggregates were found to form on top of the heterogeneous lipid domains in a phospholipid bilayer. This behaviour is limited to a few headgroup chemistries and lateral …
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