Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Phospholipid Synthesis"”.
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Phospholipid Synthesis and Incorporation Into Membranes of Rhodopseudomonas Sphaeroides
… represents the first comprehensive study of phospholipid biosynthesis as it relates to intracytoplasmic membrane (ICM) assembly in Phodopseudomonas sphaeroides. Description of the phospholipid biosynthetic pathway and demonstration of cell cycle specific intermembrane transfer of …
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Novel Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase and Lipogenesis
… the contribution of de novo fatty acid and phospholipid synthesis has not been elucidated. The data in this dissertation demonstrates the requirement of fatty acid synthesis for the generation and function of invadopodia. Inhibition of acetyl-CoA carboxylase (ACC), the rate-limiting step of …
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Role of diacylglycerol in the cellular response to lysophosphatidylcholine analogues
… stationary phase, when DAG is used to support phospholipid synthesis for membrane proliferation. Vacuolar membranes experienced constant morphological changes displaying DAG enriched microdomains co-existing with liquid-disordered areas demarcated by Vph1. Formation of these domains was …
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Defining the genetic and molecular pathways underlying motor neuron degenerative diseases
… the discovery of biallelic variants in the phospholipid synthesis (Kennedy) pathway gene, CEPT1, as causative of a complex neurological disorder associated with motor and speech delay and spasticity/ataxia. Molecular studies confirmed that disease-associated CEPT1 variants dramatically …
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Transient Metabolic Alterations Induced by Chemotherapeutics in Cancer Persisters
… demonstrate that metabolites associated with phospholipid synthesis, pyrimidine, one-carbon metabolism, and branched-chain amino acid metabolism are significantly altered in vemurafenib persister cells when compared to the bulk cancer population. Our data also show that vemurafenib persisters …
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Regulation of fatty acid synthesis in enterococcus faecalis
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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The Regulation of the Phosphatidate Phosphatase Gene <em>PAH1</em> and Its Regulatory Role on Cell Homeostasis
… to form diacylglycerides, the first step in the synthesis of triacylglycerols. Pah1p, one of the main PA phosphatases in yeast, has not only emerged as a key player in lipid biosynthetic pathways, but also acts as an important regulator of nuclear membrane biogenesis, the transcriptional …
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Role of PABP4 in intrauterine growth restriction
… essential processes such as membrane growth (via phospholipid synthesis) and cholesterol is essential for membrane fluidity and hormone synthesis. However, when glucose is not readily available lipids can substitute as energy source. Due to the interrelatedness of glucose and lipids levels, …