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Showing 1 to 20 of 20 for “"Phospholipid Bilayers"”.
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Interactions of disruptive materials with phospholipid bilayers
… to study the morphology of model supported phospholipid bilayers (SLB). Thermal and diffusive properties of membranes are identified using differential scanning calorimetry (DSC) and fluorescence correlation spectroscopy (FCS). Attenuated total reflectance infrared spectroscopy (ATR-FTIR) …
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Rate dependent rupture of solid-supported phospholipid bilayers.
An experimental study on solid-supported phospholipid bilayers was performed in order to investigate rate-dependent behavior of force and probability of bilayer rupture. 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) solid-supported lipid bilayers were created on mica using vesicle fusion …
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Nanoscale Confinement Effects on Poly(ε-Caprolactone) Crystallization at the Air/Water Interface & Surfactant Interactions with Phospholipid Bilayers
… glycol (PEG) surfactant adsorption onto phospholipid bilayers through quartz crystal microbalance with dissipation monitoring (QCM-D) measurements revealed a strong dependence of the adsorption and desorption kinetics on hydrophobic tail group structure. PEG surfactants with a single …
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Simultaneous extraction of order parameters and orientational distribution fuctions from 31[superscript]P NMR spectra of magnetically partially oriented phospholipid bilayers
… magnetically oriented 31p NMR spectra of phospholipids. A mixture of synthetic lipids, POPE and POPG, is analyzed to measure distortion of multilamellar vesicles in a magnetic field. In the analysis three models describing the shape of the distorted vesicles are examined. Ellipsoids of …
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Molecular Dynamics Simulations for the Study of Biophysical Processes on Biological Membranes
Phospholipid bilayers constitute the primary structural element of biological membranes, and as such, they play a central role in biochemical and biophysical processes at the cellular level, including cell protection, intercellular interactions, trans-membrane transport, cell morphology, and …
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A DETAILED STUDY OF PROTEIN-SUPPORTED PHOSPHOLIPID BILAYER SYSTEMS AS MODEL INTERFACES TO INVESTIGATE BIOMEMBRANE INTERACTIONS
… interaction between ionic liquids and supported phospholipid bilayers by AFM. 4) Synthesis and characterization of highly conjugated heterocyclic molecules with interesting photophysical properties.
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Microscopic and Spectroscopic Investigation Of: I. Copper-Additive Systems in Electroplating Bath. II. Supported Phospholipid Bilayer Systems
… poly(methacrylic acid) (PMA), to a supported phospholipid bilayer depresses the melting temperature and alters the morphology of the bilayer in the gel phase. AFM study of the gel-fluid phase transition in supported phospholipid bilayers shows that at ∼5°C above Tm, AFM studies reveal …
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Elucidation of the mycosamine dependent sterol binding and antifungal activities of amphotericin B
… salt-bridge interaction, 2) anchoring AmB to phospholipid bilayers and 3) binding to sterols. However, an alternative hypothesis states that AmB does not directly bind sterols but rather that sterol-induced global membrane properties are the source of the sterol dependency of AmB. This debate …
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Main Group Hydrogen-Bond Donors and Pyridyl Ligands for Supramolecular and Coordination Chemistry
… as synthetic anion transporters through phospholipid bilayers. Next, we establish synthetic methodologies for the rational design of bimetallic phosphazane coordination complexes of the type [LnM(PyridylNH)P(µ-NtBu)]2 (M = transition metal, L = supporting ligand). By optimisation of the …
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Validation of the charge equilibration lipid force field for simulations of phospholipid membranes with an application to the study of the free energetics of methyl guanidinium permeation across a DPPC bilayer
… use in molecular dynamics (MD) simulations of phospholipid bilayers. We present results to further validate these force fields by extending to simulations of a model DPPC-water monolayer. Several physical and electrostatic properties have been calculated for comparison with previously re-ported …
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Investigating Cholesterol Orientation in Lipid Bilayer by Raman Spectroscopy
… of molecules ranging from different sterols to phospholipids to membrane partitioning proteins. While the overall compositions of these various elements are understood in part, how the phospholipid bilayer in cells accommodates the different processes for the copious types of proteins is not …
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The Development of a Time-Resolved, Vesicle-Based, Fluorescence Assay for the Activity of the Lipid Kinase Pik1
… its substrate, phosphatidylinositol (PI), within phospholipid bilayers with assistance from the PI/PC transfer protein Sec14 (4). It is proposed that Sec14 stimulates the activity of Pik1 by partially removing PI from the bilayer and presenting it to the kinase as a more suitable substrate (4). In …
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Photochemical Applications to the Study of Complexity Phospholipid Bilayer Environments
… a biological membrane model, phosphatidylcholine bilayers, were investigated using novel spiropyran/merocyanine molecular probes. The femtosecond to second dynamics of this system's photochemistry enabled bilayer viscosity and free volume to be studied over a broad time scale. …
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Tools for improving and understanding microbial performance in biorenewable applications
… increased fluidity and leakage in artificial phospholipid bilayers when treated with alcohols. Also, altering just 5% of the phospholipid head groups from phosphocholine to phosphoethanolamine somewhat improved the leakiness and fluidity. Therefore, small alterations in the phospholipid …
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Studies of CD36 interacting with fatty acids, oxidized low-density lipoprotein, and the cellular plasma membrane
… in control experiments with protein-free phospholipid bilayers. To gain new insights into the physiological relevance of FA binding to CD36, we applied surface plasmon resonance (SPR) to quantify FA and oxLDL binding to the ectodomain of CD36. Structurally distinct FA [saturated, …
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Solid-State NMR Studies of Polymeric and Biomembranes
… the formation of toroidal pores and thinned bilayers in oriented zwitterionic and anionic phospholipid bilayers, (biomembrane mimetic systems), by the antimicrobial peptides (AMPs) magainin-2 and aurein-3.3, will be mentioned. The toroidal pore geometries induced by magainin-2 were different …
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Solution and solid-state NMR studies of amphotericin B
… primarily embedded as discrete ion channels in phospholipid bilayers, we have performed an extensive series of solid-state NMR experiments. These data sets enabled us to assign the 13C signals of AmB and to assess geometric and topological aspects of the structural models. The work described in …
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Quartz Crystal Microbalance Analysis of Amyloid-Beta Intermediate Aggregate Assembly: Kinetic Evaluation and theImportance of Physiological Parameters
… Intermediate aggregate affinity for supported phospholipid bilayers as well as the ability of these surfaces to support intermediate growth via monomer addition is evaluated as a function of phospholipid fatty acid saturation. Both unsaturated bilayers as well as those which incorporate …
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Investigations of the Role of Triglycerides in Synthetic Colloidal Systems
… membranes, broadly speaking, are composed of phospholipid (PL) bilayers and a variety of membrane-associated proteins that assist in the maintenance of cells and their organisms. Since the 1990's, the components of synthetic biological membranes have been employed in the design drug-delivery …