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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 88 for “"Phospholipase C"”.

  1. Molecular mechanisms regulating phospholipase C-gamma 2 activity

    Bühler, AnjaUniversität Ulm

    ulm-diss Repository record

  2. Dual Regulation of Phospholipase C-beta by G betagamma

    Kadamur Bhavani, Ganesh2018

    … betagamma subunits of the Gi family stimulate phospholipase C-beta (PLC-b) isoforms to catalyze hydrolysis of phosphatidylinositol-1,2-bisphosphate (PIP2) generating the second messengers, inositol trisphosphate (IP3) and diacylglycerol (DAG). PLC-b isoforms are also GTPase activating proteins …

    utswmed Repository record

  3. Strukturelle Voraussetzungen der Rac2-vermittelten Aktivierung der Phospholipase C-gamma2

    Christow, CarolinUniversität Ulm

    ulm-diss Repository record

  4. Localisation and function of phosphoinositide-specific phospholipase C in Sacchromyces cerevisiae

    Luo, DingUniversity of Birmingham2010

    Phosphoinositide-specific phospholipase C enzymes (PLCs) cleave the plasma membrane phospholipid PtdIns(4,5)P\(_2\) to generate two messengers, inositol (1,4,5) trisphosphate [Ins(1,4,5)P\(_3\)] and diacylglycerol (DAG). Ins(1,4,5)P\(_3\) is an important second messenger in animal cells. It …

    birmingham Repository record

  5. Funktionelle Charakterisierung von phosphomimetischen Mutanten der Phospholipase C-γ2 in intakten Zellen

    Singer, LarissaUniversität Ulm

    ulm-diss Repository record

  6. Trypanosoma Cruzi Phosphoinositide -Specific Phospholipase C (tcpi-Plc) and Its Role in Differentiation

    Okura, Michael DavidUniversity of Illinois at Urbana-Champaign2015

    … discovered Trypanosoma cruzi phosphoinositide phospholipase C (TcPI-PLC) is lipid modified in its N-terminus, and located in the plasma membrane of amastigotes. The N-terminal 20 amino acids of TcPI-PLC contain primary structural information sufficient to target the heterologous Aequorea …

    uiuc Repository record

  7. Effect of phospholipase C papain on feathering defect in 11% homogenized UHT processed cream

    Chung, Yong JooVirginia Tech1995

    … induced feathering defect near pH of 5.60 while phospholipase C treatment of cream (0.75 EU/ml) did not cause coagulation of protein and fat globules at pH 5.09. Papain-treated cream flocculated in coffee with pH 4.56 at 85°C but phospholipase C-treated cream did not. Small activity (0.075 EU/ml) …

    vt Repository record

  8. A Phosphoinositide-Specific Phospholipase C of Trypanosoma Cruzi: Unique Characteristics of a Delta-Type Homologue

    Furuya, TetsuyaUniversity of Illinois at Urbana-Champaign2015

    The phosphoinositide-specific phospholipase C gene (TcPI-PLC  ) of the protozoan parasite Trypanosoma cruzi was cloned, sequenced, expressed in E. coli, and the protein product (TcPI-PLC) was shown to have enzymatic characteristics similar to those of mammalian delta-type PI-PLCs. The …

    uiuc Repository record

  9. Untersuchung der Funktionen der beiden switch-Regionen von RhoH bei der inhibitorischen Wirkung von RhoH in Phospholipase C-vermittelten Signalwegen

    Nicola, EvelyneUniversität Ulm

    ulm-diss Repository record

  10. Synthetic studies on inositol phosphates : approaches to the synthesis of phosphatidyl inositol 3-phosphate and of potential inhibitors of phospholipase C

    Gilbert, Ian H.University of Cambridge1990

    cambridge Repository record

  11. Characterization of the Involvement of Integrins, Focal Adhesion Kinase, and Phospholipase C Enzymes Endogenous to the Oocyte in Bovine Fertilization and Oocyte Activation

    Sessions, Benjamin Rand

    utahstate Repository record

  12. Effects of Linoleic Acid on Tether Formation between Monocytes and Endothelial Cells

    Irick, Joel2008

    … in tether frequency was blocked by the U73122 phospholipase C inhibitor indicating that linoleic acid increased monocyte adhesion through a phospholipase C mediated mechanism.</p><p>Treatment with free linoleic acid did not affect the threshold force for tether extraction or the effective …

    duke Repository record

  13. Heterotrimeric G protein beta:gamma bound to a biologically active peptide : structural definition of a preferred protein interaction surface

    Davis, Tara Lynne2010

    … Gα, phosphotidylinositol 3 kinase, phosducin, phospholipase C β, adenylyl cyclase, G protein receptor kinase, G protein regulated inwardly rectifying channels, and N and P/Q type calcium channels. The 2.7Å crystal structure of Gβ1γ2 bound to a peptide (SIGKAFKILGYPDYD) obtained from a random …

    utswmed Repository record

  14. [alpha](1,3)galactosyltransferase mediated gene therapy for cancer: developing new models and improving on existing ones

    Hellrung, Daniel2006

    … thuringiensis phosphatidylinositol-specific phospholipase C (PIPLC). The PIPLC native signal sequence was replaced with the human epidermal growth factor signal sequence, EGFssPIPLC, to induce secretion from mammalian cells. (Abstract shortened by UMI.)</p>

    iastate Repository record

  15. Pressure-Induced Intracellular Signaling in Isolated Arteries

    Miriel, Victor A.2019

    … with calcium sensitizing pathways involving phospholipase C. In contrast, the expression of the proto-oncogene, c-fos, in response to pathological increases in intraluminal pressure is regulated by tyrosine kinase pathways.</p>

    odu Repository record

  16. Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference

    Kathy Marie GenzerThe University of Texas Medical Branch2008

    … studies have demonstrated a link between phospholipase D (PLD) and metabotropic glutamate receptors (mGluRs), while other studies show an interaction between dopamine receptors (DRs) and PLD. Therefore, we investigated the mechanisms of the dopamine agonist-induced synaptic plasticity that …

    utmb Repository record

  17. Ruolo della PLCγ1 e della PKCε nel differenziamento miogenico

    Gaboardi, Gian Carlo <1978>Alma Mater Studiorum - Università di Bologna2008

    Phospholipase C (PLC) has been known to be a key effector protein in signal transduction pathway for cell proliferation and differentiation. Studies on signalling through the insulin/IGF-1 receptors in muscle differentiation have revealed that PLCγ1 is involved during this process and that both …

    bologna Repository record

  18. Modulation of airway mucin glycosylation by Pseudomonas aeruginosa pyocyanin

    Jeffries, JaymeUniversity of Illinois at Urbana-Champaign2013

    … a TNF-α dependent phosphoinositol-specific phospholipase C (PI-PLC) pathway. Importantly, PA is better able to bind airway epithelial cells previously exposed to PCN. These results suggest that PA secretes PCN to induce a favorable environment for chronic colonization of CF lungs by …

    uiuc Repository record

  19. Novel interactions of the 5-HT₂ₐ and related receptors with intracellular signalling proteins

    Robertson, Derek NormanThe University of Edinburgh2006

    … GPCRs. The receptor is known to activate phospholipase C (PLC) via the heterotrimeric G proteins Gaq/n, but has been shown to also signal through the phospholipase D (PLD) pathway in an ADP-ribosylation factor (ARF)-dependent manner, that appears to be independent of Gq/n. The M3 …

    edinburgh Repository record

  20. Cxcr2 Macromolecular Complex In Pancreatic Cancer: A Potential Therapeutic Target In Tumor Growth

    Wang, Shuo2014

    … is physically coupled to its downstream effector phospholipase C-β3 (PLC-β3) that is mediated by PDZ scaffold protein Na(+)/H(+) exchange regulatory factor 1 (NHERF1) into a macromolecular signaling complex both in vitro and in pancreatic cancer cells. We also observe that disrupting the CXCR2 …

    wayne-thes Repository record

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