Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Phosphoinositide 3-kinases"”.
-
SYNTHESIS AND SCREENING OF PI3K INHIBITOR PRODRUGS FOR TREATMENT OF PROSTATE CANCER
… recurs as androgen-independent prostate cancer. Phosphoinositide 3-kinases (PI3Ks) are involved in several imperative cellular functions such as growth and survival; therefore, inhibition of PI3K induces apoptosis (programmed cell death) and suppresses tumor growth. Several compounds have been …
-
Elucidating the molecular mechanisms of p110δ activation in T cell antigen receptor signalling
Phosphoinositide 3-kinases (PI3Ks) are activated in immune cells downstream of the antigen recognition receptors, the signals from which are crucial for the development, differentiation and activation of lymphocytes. Engagement of the T cell antigen receptor (TCR) initiates a signalling cascade …
-
Investigating the isoform-specific role of phosphoinositide 3- kinase p110delta
Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that regulate a diverse array of biological functions in every cell type by generating lipid second messengers. The PI3K family is comprised of multiple isoforms that are divided into three main classes; class I, II and III. All class I …
-
Designing Compounds that Probe the Phosphatidylinositol 3-Kinase Signalosome
Phosphoinositide 3-kinases (PI3K) are major regulators of many cellular functions, and its hyperactivation is a major target for anticancer drug discovery. PI3Kα is the isoform most implicated in cancer, and this thesis is dedicated to investigating how specific protein-ligand interactions in the …
-
Gene therapy for axon regeneration
… by using vectors containing CRISPR-Cas9 and phosphoinositide 3-kinases. Chapter I is a literature review about cell surface receptors called integrins and their role in axonal regeneration. Integrins contribute to the spontaneous axon regeneration in the peripheral nervous system by …
-
Simulated impact trauma and osteoarthritis: the role of cell volume and mechanotransduction
… (uridine; calcium mobilizing mediator) and the phosphoinositide 3-kinases (PI3K) inhibitor wortmannin were used to determine its mechanism of action. Wortmannin alone increased cell death and inhibited REV5901 chondroprotective effects with no alteration in cell volume compared to REV5901 alone. …
-
Mechanistic Investigation of Genotype-Phenotype Correlations in PIK3R1-Related Diseases
… - that are regulatory subunits of Class IA phosphoinositide 3-kinases (PI3Ks). These regulatory subunits heterodimerise with one of three catalytic subunit isoforms, namely p110$\alpha$, p110$\beta$, or p110$\delta$. Class IA PI3Ks are critical enzymes involved in fundamental metabolic and …
-
The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling
… PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling Abstract Class I phosphoinositide 3-kinases (Class I PI3Ks) are essential players involved in the signalling events in the cell and are critical promoters of cellular growth, survival and metabolism. Once …
-
DISSECTING THE FUNCTION AND INTERACTOME OF PLEKHS1 IN PROSTATE TUMORIGENESIS
… product and key signalling output of Class I phosphoinositide 3-kinases (PI3Ks) and acts as a coordinator of a huge network that controls cellular processes such as metabolism, cell growth and movement. Mutations that augment the activity of this network are amongst the most common drivers of …
-
Signalling reactions of PI3Kgamma in T cells
Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases involved in the regulation of diverse important cellular functions. The members of PI3K class I exhibit dual enzymatic specificity both as lipid kinases and protein serine kinases, and they are known to be indispensable for the …