Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Phosphoethanolamine"”.
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Phosphoethanolamine methyltransferases inhibitors with broad-spectrum anthelmintic effect against livestock nematodes
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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A Family of Phosphoethanolamine Transferases That Function in GPI Anchor Assembly in Saccharomyces Cerevisiae
My results support models for branching of the GPI assembly pathway, and highlight differences between GPI synthetic enzymes of yeast and mammals that could be exploited therapeutically.
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Complexity of the Late Stages of GPI Anchor Biosynthesis in Saccharomyces Cerevisiae
… PIG-F protein, a protein suspected of adding phosphoethanolamine to the third mannose of the mammalian GPI anchor. Genetic disruption of the yeast PIG-F gene (termed GPI11), demonstrated that it is essential for vegetative growth. Yeast gpi11 mutants in which the Gpi11 protein (Gpi11p) could …
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Mechanism Determination of the Effects of Pancratistatin on Model Mitochondrial Membranes
… (POPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), and tetraoleoyl cardiolipin (TOCL). Small-angle neutron and X-ray scattering (SANS and SAXS) were utilized to determine how PST influences membranes structure. Molecular dynamics (MD) simulations were used to compliment …
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Time Delayed Protein Complementation
… with growth: threonine, 29.2%; and leucine, phosphoethanolamine, taurine and serine <6.5%. This study confirms previous work in this laboratory which suggested that vegetable proteins fed 5 hours apart in combined or alternating fashion had equal growth promoting capacity. Contrary to …
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Development of a Biosensor for Investigating Membrane Curvature Sorting
… and 1,2-dihexadecanoyl-<em>sn</em>-glycero-3-phosphoethanolamine, sense curvature by accumulating in areas over nanoparticles, and both are able to laterally exchange with surrounding lipids. Dynamic fluidity of the bilayer was assessed using fluorescence recovery after photobleaching. Lipids …
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O-H activation in phosphates: oxidative addition to an iridium(I) center and reactivity of the resulting iridium(III) species
… with 1,2- dihexadecanoyl-rac-glycero-3-phosphoethanolamine (PEA), a dialkyl phosphate, produced only the N-H addition product.
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Engineering Lipid Nanoparticle-Mediated Delivery of Nucleic Acids to Lymphoid Organs and Immune Cells
… cells and neutrophils. Phospholipids containing phosphoethanolamine (PE) head groups likely increase endosomal escape due to their fusogenic properties. Additionally, it was found that negatively charged phospholipids drive spleen tropism. The use of a spleen selective organ targeting (SORT) …
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Tools for improving and understanding microbial performance in biorenewable applications
… phospholipid head groups from phosphocholine to phosphoethanolamine somewhat improved the leakiness and fluidity. Therefore, small alterations in the phospholipid composition could be helpful in creating more robust membranes.</p>
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Vitamin B12 impacts amyloid-β induced proteotoxicity by regulating the methionine/s-adenosylmethionine cycle
… (PtdCho) through SAMe dependent methylation of phosphoethanolamine. Supplementation with either choline or PtdCho delayed Aβ-induced paralysis. Together, these results suggest a model in which vitamin B12 dependent methionine/SAMe cycle activity increases phosphatidylcholine production to reduce …
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Periplasmic Modification of the 1-Phosphate Group of Lipid A in Gram-Negative Bacteria.
… two enzymes, a lipid A phosphatase and a phosphoethanolamine (pEtN) transferase, involved in modifying the 1-position of <em>H. pylori</em> lipid A. <em>H. pylori</em> lipid A contains a pEtN unit directly linked to the 1-position of the disaccharide backbone. This is in contrast to the …
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DOES FAT MATTER? Lipidomics investigations during Blue mussel (Mytilus sp.) hatchery production
… ripe from undeveloped ovaries, such as ceramide phosphoethanolamine (PE-Cer) 40:1 and the saturated ether-linked glycerophosphocholine (PC) O-30:1/P-30:0b (area under the curve, AUC>0.9). The thesis is completed by two chapters dealing with diet feeding trials on mussel larvae and juveniles. …
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Amphiphilic Cell-Penetrating Hybrid Cyclic-Linear Peptides as a Drug Delivery System
… and absence of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE). [R<sub>6</sub>K]W<sub>6</sub> and [R<sub>5</sub>K]W<sub>5 </sub>were found to be very efficient in the delivery of siRNA. Furthermore, co-formulation of peptides with lipid DOPE significantly enhanced the efficiency of …
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Investigation of the Structure of Alkyne Self-Assembled Monolayers on Gold and the Development of Matrix-Enhanced Secondary Ion Mass Spectrometry Methods
… DPPC) and 1,2-dipalmityl-sn-glycero-phosphoethanolamine: DPPE) were at least two orders of magnitude better. The data also show that ILs are suitable matrices for imaging SIMS. The IL matrices did not cause changes to the sample surface; no ¡°hot spots¡± were observed. The …
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Design, Development and Evaluation of Erlotinib-Loaded Hybrid Nanoparticles for Targeted Drug Delivery to NonSmall Cell Lung Cancer
… cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000) respectively. ETB was loaded into CSLAHNPs by incubation method. Murine anti-EGFR monoclonal antibody (mAb) was reduced to hAb using tris(2- carboxyethyl)phosphine and …
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A Study of the Membrane Binding Properties of the Matrix Protein from Human Respiratory Syncytial Virus
… the lipid head group is phosphocholine or phosphoethanolamine. It interacts differently with monolayers containing sphingomyelin, which in combination with cholesterol forms phase separated liquid-ordered (Lo) microdomains. RSV M was found to bind extrinsically to the …
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Surface Functionalisation of Metal-Organic Frameworks for Biomedical Applications
… phospholipids—1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)—to enhance its internalisation in cancer cells. The coated MOFs underwent a full physicochemical characterisation …
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Towards Combined Computational and Experimental Studies on Toxicity of Silver Nanoparticles
… head are the phosphocholine (PC) and phosphoethanolamine (PE), which are abundant in HepG2 cells. Computational study shows that the presence of Ag+ results in partial oxidation of both the phospholipid heads. Our preliminary experimental and computational studies lead us to develop …
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Sustained hydrogel-based delivery of RNA interference nanocomplexes for gene knockdown
… with PEG and a lipid 1, 2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) molecule, commercial lipid based Lipofectamine® RNAiMax and Invivofectamine® 3.0 nanoparticles. D and MD achieved better RNase protection compared to lipid nanocomplexes though Invivofectamine® 3.0 nanocomplexes protected …
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Anti-Obesity Effects of Adipose-Targeting Resveratrol Nanocarriers
… GSWKYWFGEGGC) to 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-5000] (DSPE-PEG5000-Maleimide) to form DSPE-PEG5000-Peptide conjugate, which is used to synthesize ligand-coated Rnano (L-Rnano). The ASC-targeting peptide and hydrophilic heads of DSPE and …
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