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Showing 1 to 12 of 12 for “"Phosphodiesterase 5"”.
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PHOSPHODIESTERASE-5 INHIBITION: A NOVEL STRATEGY TO IMPROVE STEM CELL THERAPY IN THE HEART
… Recent studies have shown that inhibition of phosphodiesterase-5 (PDE-5) is a powerful strategy to precondition the heart and cardiomyocytes against ischemia/reperfusion injury. We therefore tested the hypothesis that inhibition of PDE-5 with sildenafil (Viagra®) or selective knockdown with a …
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Long-term cardioprotection with phosphodiesterase-5 inhibition against ischemia-reperfusion injury: Role of nitric oxide.
Recent studies have shown that the potent phosphodiesterase-5 (PDE-5) inhibitor, sildenafil citrate, induces a powerful cardioprotective effect against ischemia-reperfusion (I/R) injury in rabbit and mouse hearts. However, the effect of this drug in inducing long-term protection against I/R injury …
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Thick Ascending Limb Nitric Oxide Production And Inhibition Of Nkcc2 Activity Are Impaired In Angiotensin Ii-Induced Hypertension
… and this was restored by inhibition of phosphodiesterase 5.</p> <p>In conclusion, we found that in angiotensin II-induced hypertension THAL NO production is reduced and NO-induced inhibition of NKCC2 activity is blunted due to increased phosphodiesterase 5 activity. We believe this could …
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Biosynthesis and medicinal chemistry of therapeutically promising plant natural products
… with improved potency in inhibiting human phosphodiesterase-5. We subsequently identified and characterized a novel flavonoid prenyltransferase and O-methyltransferase from the medicinal herb Epimedium sagittatum that is known to produce many bioactive prenylated and methylated flavonoids.
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Liposomal delivery of PDE5 inhibitors and UT-15C to human erythrocytes
… of drugs such as prostacyclin or its analogs and phosphodiesterase 5 (PDE5) inhibitors. These medications can be used alone or in combination and may have serious unwanted side effects that are additive when used in combination.</p><p>Here an alternative drug delivery technique using drug-loaded …
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NOVEL STRATEGIES TO IMPROVE METABOLIC PARAMETERS AND PRECONDITION DIABETIC HEARTS AGAINST ISCHEMIA/REPERFUSION INJURY
… We hypothesized that daily administration of the phosphodiesterase-5 inhibitor tadalafil (TAD) ± the curcumin analogue (HO-3867) will attenuate inflammation, improve metabolic parameters and reduce infarct size after ischemia/reperfusion injury (IRI). Furthermore, we propose that TAD therapy will …
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Type-5 Phosphodiesterase Inhibition in the Prevention of Doxorubicin Cardiomyopathy
… are designed to determine if sildenafil, a phosphodiesterase-5 inhibitor and known mitochondrial KATP channel opener, would protect against chronic doxorubicin cardiomyopathy both in vivo and in vitro.Male ICR mice were randomized to 1 of 4 treatments: saline, sildenafil (0.7 mg/kg IP), …
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The effects of statins on hypoxia-induced proliferation and cell signalling pathways in pulmonary artery fibroblasts
… with the prostacyclin analogue treprostinil, the phosphodiesterase-5 inhibitor sildenafil and the endothelin-1 antagonist bosentan were negative. Bosentan, however, inhibited the hypoxic PAF-PASMC interaction, suggesting endothelin-1 release by hypoxic PAFs, with proproliferative effects on …
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Novel Strategies in Cardioprotection against Ischemia/Reperfusion Injury
… preconditioning (PC) of the heart. Phosphodiesterase type 5 (PDE-5) is an enzyme that specifically hydrolyzes cGMP thereby decreasing its tissue concentration. Sildenafil is a potent selective inhibitor of PDE-5 and therefore allows the accumulation of cGMP in several tissues shown …
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Biochemische Charakterisierung des ADP-Rezeptors P2Y12 und pharmakologische Therapiekontrolle von Thrombozytenfunktionshemmern
… Aktivierung von cyclonukleotidabbauenden Phosphodiesterasen, sondern auf Grund einer Aktivierung der cGMP-abhängigen Proteinkinase. In Anbetracht der essentiellen Bedeutung der Gi-Protein Stimulation für die Plättchenaktivierung stellt dies einen wichtigen Mechanismus dar, wie das aus dem …
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Ανάδειξη νεφροπροστατευτικής δράσης φαρμακευτικών παραγόντων σε πειραματικό μοντέλο ισχαιμίας επαναιμάτωσης στον επιμύ
Σκοπός της μελέτης: Μολονότι τα τελευταία χρόνια έχει επιτελεστεί σημαντική πρόοδος στην κατανόηση του παθοφυσιολογικού μηχανισμού πίσω από το φαινόμενο της βλάβης εξ ισχαιμίας και επαναιμάτωσης στο νεφρό, υπάρχει έλλειψη φαρμακευτικών παραγόντων στην κλινική πράξη που να μπορούν να την ανατρέψουν. …
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PATHOGENIC ROLE OF PHOSPHODIESTERASE TYPE 5 UPREGULATION IN CARDIAC ISCHEMIA/REPERFUSION INJURY
Phosphodiesterase Type 5 (PDE5) inhibitors are cardioprotective against ischemia/reperfusion (I/R) injury. However, it remains uncertain if I/R affects PDE5. We hypothesized that generation of reactive oxygen species (ROS) during I/R leads to upregulation of PDE5, which contributes to pathological …