Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Phosphatidylinositol Phosphates"”.
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Modulation of host phosphatidylinositol phosphates by salmonella effector protein SOPB
… SopE2 activates Cdc42 only. SopB is a known phosphatidylinositol phosphate phosphatase possessing both 4- and 5-phosphatase activities promoting membrane ruffling and invasion. The mechanisms through which SopB utilizes its phosphatase activities to mediate membrane ruffling and invasion are …
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Deciphering The Role of Huntingtin In Endosomal Functions
… tested HTT’s effect on the production of phosphatidylinositol phosphates, the sizes and maturation of endosomes and lysosomes such as lysosomal acidification, and the subcellular distribution of different endosomal markers. My findings support a critical role of HTT on endosome maturation, …
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Molecular mechanisms of Sorting nexin-9 in membrane triggered actin polymerisation
… SNX9 are able to integrate inter- actions with phosphatidylinositol phosphates (PIPs) at membranes, and membrane curvature sensing to trigger actin polymerisation via the Arp2/3 complex. While membrane binding is key in in vitro purified reconstitutions of actin polymerisation, the lipid …
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Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
… a lipid-binding domain, with phosphoinositides (phosphatidylinositol phosphates or PIPs), an important class of regulatory phospholipids. PH domains are presumed to bind PIPs, but specific interaction with and regulation by PIPs for most PH domain-containing protein remains unclear. …
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PI(4)P-Dependent Recruitment of Clathrin Adaptors to the Trans-Golgi Network
… found that the Golgi is particularly enriched in phosphatidylinositol 4 phosphate [PI(4)P] and that the clathrin adaptor AP-1 binds PI(4)P directly, suggesting that PI(4)P binding may specify the TGN-specific recruitment in conjunction with Arf1. My studies showed that another monomeric clathrin …