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Showing 1 to 20 of 36 for “"Phosphatidylinositol 4,5-bisphosphate"”.
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Dual regulation of inositol 1,4,5-trisphosphate receptors by inositol 1,4,5-trisphosphate and phosphatidylinositol 4,5-bisphosphate
… temporal patterns of Ca<sup>2+</sup> signalling. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P<sub>2</sub>) is a minor, but functionally diverse lipid at the PM. In the canonical Ca<sup>2+</sup> signalling cascade, activation of PM-resident receptors such as G-protein coupled receptors (GPCRs) …
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A study on PIP5Kalpha degradation by Nedd4-1-mediated ubiquitination
Phosphatidylinositol 4,5-bisphosphate (PIP2) is a critical lipid mediator of diverse membrane processes including vesicle trafficking, actin cytoskeleton dynamics and cell signaling at the cell surface, indicating significance of spatiotemporal regulation and underlying mechanism of PIP2 …
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Type I PIP5Kα negatively regulates NGF-induced neurite outgrowth in PC12 cells
"Type I phosphatidylinositol 4-phosphate 5-kinase (PIP5KI) is responsible for the production of a membrane lipid, phosphatidylinositol 4,5-bisphosphate (PtdIns[4,5]P2). Here, I have examined whether PIP5KIα, an isoform of PIP5Kα, plays a role in neurite outgrowth. For this, I generated a stable …
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Regulatory role of phosphatidylinositol 4-phosphate 5-kinases in brain inflammation
Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], mainly produced by the type I phosphatidylinositol 4-phosphate 5-kinase (PIP5KI) family members, PIP5KIα, PIP5KIβ and PIP5KIγ, is an important regulator of diverse cellular processes at the cell surface, such as cell survival, cell proliferation, …
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The 5' inositol phosphatase SHIP2 regulates EGF-elicited protrusion in MTLn3 cells
… that catalyzes the dephosphorylation of phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P 3) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) as well as the dephosphorylation of phosphatidylinositol 4,5- bisphosphate (PI(4,5)P 2). PI(3,4,5)P 3 and P][(4,5)P 2 are two major …
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Self-assembly of filopodia-like structures on supported lipid bilayers
… extracts to supported lipid bilayers containing phosphatidylinositol(4,5)bisphosphate, PI(4,5)P 2. The FLSs recapitulate important characteristics of filopodia - they assemble parallel actin bundles from the lipid membrane and they form in the presence of capping activity. Known filopodial tip …
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Membrane binding properties of Disabled-2
… (PTB) domain mediates protein binding to phosphatidylinositol 4,5-bisphosphate (PIP2) at the inner leaflet of the plasma membrane and helps co-localization with clathrin coats. Dab2, released from platelet alpha granules, inhibits platelet aggregation by binding to the °IIb? integrin …
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Functions of Phosphatidylinositol 4-Phosphate 5 Kinases in Actin Cytoskeletal Regulation During Phagocytosis
Phosphatidylinositol (4,5)-bisphosphate (PIP2) is a crucial signaling phosphoinositide at the plasma membrane (PM) which mediates a variety of biochemical activities and cellular functions. It is primarily synthesized by type I phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) through the …
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Trpv5: Structure, Function And Drug Discovery
… and the abundant plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) which act as an inhibitor and activator, respectively. By solving the structures of TRPV5 in the presence of these modulators as well as TRPV5 in an apo state we clearly identified the binding …
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Phosphatidylinositol 4-phosphate 5-kinase Involved in Neuroglial Toll-like Receptor Signaling
… studied. It was previously demonstrated that phosphatidylinositol 4,5-bisphosphate (PIP2), a membrane lipid produced mainly by the type I phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family members, was necessary for TLR4 signaling. However, details of the PIP5K-mediated PIP2 production …
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Beteiligung der Phospholipase D an der Regulation der Synthese von Phosphatidylinositol-4,5-bisphosphat durch Arf- und Rho-GTPasen
… phosphatidic acid (PA), was found to stimulate phosphatidylinositol-4-phosphate-5-kinase (PIP-5-kinase) activity in vitro. In the present study, we have examined wether PLD affects the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) by PIP-5-kinase. Overexpression of PLD isoforms in …
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Cofilin
… PI3-kinase and one of its substrates, namely phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) which can bind to cofilin, co-localize within CD2-receptor caps. The cofilin/F-actin interaction has been identified as a crucial regulatory element for receptor cap formation and the strength of …
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How to Mend a Broken Heart: Massive Endocytosis and the Role of Lipidic Forces in Membrane Trafficking
… or through coupled calcium-mediated fusion and phosphatidylinositol 4,5-bisphosphate (PIP2) signaling. Both forms of MEND do not rely on classical endocytic proteins such as clathrin or dynamin and appear independent of the cytoskeletal or extracellular matrix. A hypothesis emerged implicating …
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Divalent Cation- and Cholesterol-Induced Perturbation in Pip2 Lateral Organization in Model Membranes - Cluster formation, Phase Partitioning, and PiP2-Protein interactions
… of polyphosphoinositides (PPI), and especially phosphatidylinositol 4,5-bisphosphate (PIP2), has been documented in numerous reports. As large number of proteins bind PIP2 but much more is known about the biochemical interactions between PIP2 and purified proteins in vitro than about the …
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Regulatory and Gating Mechanisms of TMEM16A Chloride Channel
… simulation, we first demonstrate that the phosphatidylinositol-(4,5)-bisphosphate (or PI(4,5)P2) plays a critical role in TMEM16A’s Ca2+-dependent activation and desensitization. We identify key basic residues at the cytosolic interface of transmembrane segments (TMs) 3–5 as the putative …
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Identification and characterization of the acid phosphatase from Francisella tularensis and its potential role in pathogenesis
… by phosphatase-catalyzed dephosphorylation of phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate is believed to play an important role in the intracellular survival of these pathogens. Results from this study show that the intracellular pathogen, F. tularensis (Ft) produces …
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Unravelling Spiral Ganglion Neuron Electrophysiology: Heterogeneity, Gene Therapy, and In-Vitro Testing Models
… therapy approach through the activation of the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta (PIK3CD) gene has been investigated for its potential for SGN regeneration. This gene encodes for phosphoinositide 3-kinase (PI3K), a key initiator of the PI3K/Akt/mTOR pathway. …
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Molecular Characterization and Loss-of-Function Analysis of an Arabidopsis thaliana Gene Encoding a Phospholipid-Specific Inositol Polyphosphate 5-Phosphatase
The phosphatidylinositol signaling pathway utilizes inositol-containing second messengers to mediate signaling events. The enzymes that metabolize phosphoinositides can in some cases serve to terminate the signaling actions of phosphoinositides. The inositol polyphosphate 5-phosphatases (5PTases) …
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PIP5-Kinase Dependent PIP2 Generation Impairs T Cell Activation by Rigidifying the Actin Cortex
… are spatially and temporally regulated by phosphatidylinositol 4,5-bisphosphate (PIP2) (Sechi et al, 2000; Yin et al., 2003; Logan et al., 2006). How actin dynamics is regulated by PIP2 in T cell activation is unclear. Generation of PIP2 at the plasma membrane can be accomplished by the …
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Genetic studies on functional redundancy between profilin1 and profilin2 im mice and the role of the profilin ligand Mena in neuronal cell function and mouse behavior
… in respect to their interactions with actin, phosphatidylinositol-4,5-bisphosphate (PIP2), and proteins containing poly-L-proline rich motives among which the Ena/VASP protein family members such as Mena. While profilin1 is highly expressed throughout development and adulthood in most tissues …
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