Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Phosphatidylinositol 4,5-Diphosphate"”.
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PIP5-Kinase Dependent PIP2 Generation Impairs T Cell Activation by Rigidifying the Actin Cortex
… are spatially and temporally regulated by phosphatidylinositol 4,5-bisphosphate (PIP2) (Sechi et al, 2000; Yin et al., 2003; Logan et al., 2006). How actin dynamics is regulated by PIP2 in T cell activation is unclear. Generation of PIP2 at the plasma membrane can be accomplished by the …
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Differential Regulation of Phosphatidylinositol 4-Phosphate 5 Kinase Beta during Hypertonic and Oxidative Stress
… role in regulating cellular homeostasis. The phosphatidylinositol derivative, PI(4,5)P2 (PIP2)is an essential mediator of cellular processes such as signal transduction, membrane traffic, actin cytoskeleton, ion homeostasis, growth and apoptosis. Despite the importance of this signaling …
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Crosstalk Between Calcium Signaling and Lipid Metabolism at Endoplasmic Reticulum-Plasma Membrane Junctions
… Ca2+ signals is dependent on the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) at the plasma membrane (PM). To enable subsequent signaling activation and maintain cellular homeostasis, it is necessary to replenish the consumed PIP2. However, the molecular mechanisms underlying PM …
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Molecular Basis of Coupling Calcium Sensing to Fast Membrane Fusion by Synaptotagmin-1 in Neurotransmitter Release
Neuronal communication depends on the rapid release of neurotransmitters through Ca2+-triggered synaptic vesicle exocytosis. Synaptotagmin-1 (Syt1) acts as the Ca2+ sensor for fast, synchronous neurotransmitter release. Despite decades of research, the precise molecular mechanism of Syt1 action and …