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Showing 1 to 20 of 47 for “"Phosphatidic acid"”.
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Regulation of mTORC1 by phosphatidic acid: mechanism and structural insight
… mechanism by which the lipid second messenger, phosphatidic acid, activates mTOR complex 1. The mammalian target of rapamycin complex 1 (mTORC1) is regulated, in part, by the endogenous inhibitor DEPTOR. However, the mechanism of DEPTOR regulation with regard to rapid mTORC1 activation remains …
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Identifying the Role of Phospholipase D1 and Phosphatidic Acid in Exocytosis
… D1 (PLD1), and its product, the lipid phosphatidic acid (PA), are involved in multiple exocytic processes. However, PLD1 and PA’s role in this process has remained unclear. In this work, PLD1 and the production of PA were visualized during exocytosis, and PA localization to regions of …
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The regulation of yeast homotypic vacuole fusion by phosphatidic acid and diacylglycerol
… for fusion to occur includes ergosterol, phosphatidic acid (PA), diacylglycerol (DAG), and phosphoinositides. However, the interactions and effects each of these lipids has throughout the stages of membrane fusion has not been elucidated. This project aimed to identify specific regulatory …
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Lateral organization and dynamics of phospholipids in membrane
… phosphatidylethanolamine, or phosphatidic acid. However, another integral membrane protein, D-$\beta$-hydroxybutyrate dehydrogenase (BDH), reorganized the phospholipids in the bilayer into a nonrandom distribution. Although the enzyme has a specific requirement for …
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Identification and quantification of lipid metabolites in cotton fibers: Reconciliation with metabolic pathway predictions from DNA databases.
… hirsutum, L) fibers was determined. Fatty acid profiles revealed that linolenate and palmitate were the most abundant fatty acids present in fiber cells. Phosphatidylcholine was the predominant lipid class in fiber cells, while phosphatidylethanolamine, phosphatidylinositol and …
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Structural Basis for Dishevelled-2 Association to the Plasma Membrane
… the recruitment of ionic lipids, such as phosphatidic acid, to regulate its localization to the plasma membrane and association to the frizzle receptor. However, the physical mechanism for DEP association to the plasma membrane is still unknown. We show that mDvl2-DEP interacts with …
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Elucidating the Role of Yeast Lipin (PAH1) in Lipid Droplet Biogenesis
… will be to understand the role of the phosphatidic acid hydrolase (Pah1p) in the biogenesis of lipid droplets in Saccharomyces cerevisiae. Pah1p is an enzyme that converts phosphatidic acid to diacylglycerol, and its absence or elimination of its catalytic activity results in the …
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Hormonal regulation of phosphatidylcholine metabolism in Apium graveolens
… using plant growth inhibitors and gibberellic acid led to the hypothesis that two pools of phosphatidylcholine exist within the plant cell; one capable of producing signals involved in cell proliferation and the other capable of releasing signaling molecules which facilitate cell …
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The Effect of The Modification of The Acidic and Zwitterionic Phospholipid Composition on The Enzymatic Activity of D-Beta-Hydroxybutyrate Dehydrogenase
… Phospholipase D was used to increase the acidic phospholipid composition. This enzyme hydrolyzed primarily zwitterionic phospholipids to phosphatidic acid, an acidic phospholipid. The accumulation of phosphatidic acid increases the electrostatic potential at the surface of the membrane. …
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Interactions of Inorganic Mercury and Inorganic Cadmium with Biomimetic and Complex Biological Membranes and their Influence on Membrane Packing and Size
… a suppression of the Tm of membranes composed of phosphatidic acid (PA), cardiolipin (CL), phosphatidylserine (PS), phosphatidylglycerol (PG) and phosphatidylinositol (PI). Cd2+ induces more rigidity in rigid anionic membranes compared to more fluid anionic membranes. These results further our …
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Therapeutic targeting of DGKA-mediated macropinocytosis in lymphangioleiomyomatosis
… cells, marked by the accumulation of phosphatidic acid and ceramides. Treatment with ritanserin leads to the accumulation of diacylglycerol and phospholipids, as well as a reduction in phosphatidic acid. CONCLUSIONS: TSC2-deficient cells rely on macropinocytosis to meet their metabolic …
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The Tumor Suppressor BRCA1 in IP3R Calcium Signaling and Apoptosis
… BRCT (BRCA1 C-Terminus) domain of BRCA1. Lastly, phosphatidic acid, which is was identified in a lipid binding screen, is produced at the ER during apoptosis suggesting a mechanism for apoptotic recruitment of BRCA1 to the ER. These findings provide a mechanistic explanation by which BRCA1 can act …
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D2R Dopamine Receptor Mediates Changes in Dual Specificity Phosphatase Expression in a Small Cell Lung Cancer Cell Line
… induced by treatment with exogenous arachidonic acid (AA). In addition, the NPA mediated increases in these genes was inhibited by 5,8,11,14‑eicosatetraynoic acid (ETYA) an AA analog and inhibitor of downstream activity, suggesting NPA induction of these three genes is AA dependent. Ethanol …
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Lipid composition and membrane physical parameters regulate priming and SNARE function in yeast vacuole membrane fusion
… lipids that includes ergosterol, diacylglycerol, phosphatidic acid and phosphoinositides. Although a lot is known about the SNARE protein machinery, the role of lipids and the lipid environment of the membrane are not clear. For long, lipids had been thought to play a passive role by binding …
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Η TETRAHYMENA PYRIFORMIS ΣΑΝ ΒΙΟΧΗΜΙΚΟ ΣΥΣΤΗΜΑ ΜΕΛΕΤΗΣ ΤΩΝ ΔΡΑΣΕΩΝ ΚΑΙ ΤΗΣ ΠΑΡΑΓΩΓΗΣ ΤΟΥ ΠΑΡΑΓΟΝΤΑ ΕΝΕΡΓΟΠΟΙΗΣΗΣ ΑΙΜΟΠΕΤΑΛΙΩΝ
… SITES. AGEPC (10-6M) RAISES THE LEVEL OF THE PHOSPHATIDIC ACID CONTENT OF THE PROTOZOAN LIPIDS. CHANGES APPEAR TO ALL THE SPECIES OF ACYL CHAINS, WITH MORE PRONOUNCED THAT OF THE PHOSPHATIDYLCHOLINE FRACTION. THERE WAS ALSO A DRASTIC DECREASE OF THE 1-0-ALKYL-5N-GLYCERYL-3-PHOSPHORYLCHOLINE …
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Design, Synthesis, and Evaluation of Small Molecules in the Discovery of Novel Antimicrobial Agents
… of novel inhibitors of the PlsX/PlsY pathway to phosphatidic acid, a key intermediate in the biosynthesis of phospholipids in Gram-positive bacteria. Substrate mimics, incorporating various bioisosteric replacement head groups, were discovered demonstrating good enzyme inhibition and good …
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The role of the Dgk1 and Pah1 in lipid interconversion on saccharomyces cerevisiae vacuole physiology, homeostasis, protein sorting and fusion
… and regulatory lipids. The deletion of the phosphatidic acid (PA) phosphatase gene Pah1, which converts PA in diacylglycerol kinase (DAG), was previously shown to produce a fragmented vacuole phenotype, greatly inhibit fusion and result in the vacuolar protein sorting defect. As such, the …
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Nanoscale Organization of The Small Gtpase Rac1
… found that Rac1 selectively associates with phosphatidic acid (PA) and phosphoinositol (3,4,5)-trisphosphate (PIP3), resulting in nanoclusters enriched in these anionic lipids. I found these lipids to be structurally important as depleting the PM of PA or PIP3 impaired both Rac1 PM targeting …
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Biochemical and physiological studies of Arabidopsis thaliana Diacylglycerol Kinase 7 (AtDGK7)
… the substrate diacylglycerol (DAG) to generate phosphatidic acid (PA) . Both molecules, DAG and PA, are involved in signal transduction pathways. In the model plant Arabidopsis thaliana, seven candidate genes (named AtDGK1 to AtDGK7) code for putative DGK isoforms. Here I report the molecular …
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Understanding the Genome-Wide Response of Streptomyces coelicolor to the Glycopeptide Antibiotic Teicoplanin
… characterisation of a group of genes with phosphatidic acid phosphatase activity which affected the sensitivity of S. coelicolor to a broad range of cell wall targeting antibiotics. One of these genes, SCO6355, significantly counteracted the intrinsic vanRSHAX resistance system of S. …
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