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Showing 1 to 20 of 183 for “"Phosphatases"”.
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The Chemotaxis Phosphatases cheC and cheX
The CheY-P phosphatase CheC is important for chemotactic adaptation. The phosphatase ability of CheC is enhanced nearly five fold upon association with CheD. In this study, CheC mutants were generated in putative active site residues and the CheD binding helix. The mutants were examined for in vivo …
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Structure/function studies of protein phosphatases
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1995.
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Protein phosphatases and protein kinases in dictyostelium
… and partial characterization of 5 protein phosphatases, 6 paranitrophenyl phosphate (pnpp) phosphatases and 2 protein kinases from <i>Dictyostelium</i> are described. .Two of the protein phosphatases are shown to have subunit structures. All of the protein phosphatase activities described …
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Specificity of SH2 domains and protein tyrosine phosphatases
… PTK activity. SH2 domains and protein tyrosine phosphatases (PTPs) play essential roles in transmitting these signals. SH2 domains are small domains of V100 amino acids that bind to phospho-tyrosine (pY) in the context of adjacent amino acids. and PTPs counteract the activity of PTKs by removing …
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DNA catalysts as phosphatases and as phosphoserine lyases
… directed towards identifying sequence-selective phosphatases deoxyribozymes, we were unsuccessful in accomplishing this specific goal of selectivity in the context of peptide sequence discrimination. Dehydroalanine (Dha) is a non-proteinogenic electrophilic amino acid that serves as a synthetic …
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Regulation of DNA replication by PP2A family phosphatases
… PP2A-Rts1 and PP2A-Cdc55, alongside PP4, as the phosphatases responsible for Sld3 dephosphorylation and partially of Sld2. To overcome the pleiotropy of these phosphatases hindering S phase analysis, I identify the Sld3-PP2A-RTS1 interaction site and mutation of this site affects Sld3 …
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Role of phosphatases in controlling arabidopsis mapk signalling cascades
… (MKP) sub-class of dual-specificity tyrosine phosphatases have been recognized as key players for inactivating MAPKs. Five MKP homologues are found in Arabidopsis thaliana, but only limited information is available concerning their properties and biological roles. Based on initial data derived …
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Leveraging Local Perturbations to Map Allosteric Networks of Phosphatases
… Conformationally dynamic human Protein Tyrosine Phosphatases (PTPs) exemplify the challenges and opportunities associated with allostery. The archetypal PTP, PTP1B, has been highly validated as a therapeutic target but no allosteric inhibitors have been approved for clinical use. This is largely …
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Role of CDC25 Phosphatases in Non-Melanoma Skin Cancer
… activators, the cell division cycle 25 (CDC25) phosphatases, and also activates Erbb family members indirectly through reactive oxygen species (ROS)-inhibition of tyrosine phosphatases to stimulate proliferation. CDC25 family members, including CDC25A, CDC25B and CDC25C, are over-expressed in …
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Role of phosphatases in the end-on conversion process
… unknown. This project aimed to study the role of phosphatases in the regulation of the end-on conversion process. First, I investigated the different contribution of the two outer-kinetochore phosphatases - BubR1- recruited PP2A-B56 and KNL1-recruited PP1 - in counteracting Aurora B kinase during …
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Dual-specific protein phosphatases in the <i>Archaea</i>
… sequence similarity among the three families of phosphatases. All known LMW PTP remove phosphoryl groups esterified to the hydroxyl amino acid: tyrosine, whereas all members of the Cdc25 family are dual-specificity protein phosphatases that dephosphorylate all the hydroxyl amino acids: tyrosine, …
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Structural and Functional Studies of Escherichia coli Kinases and Phosphatases
… a protein phosphatase), and two nucleotide pyrophosphatases, YjjX and YhdE. X-ray crystallographic structure determination combined with bioinformatics analyses, mutageneses and biochemical experiments, both in vitro and in vivo, were utilized for the functional characterization of each protein. …
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Role Of Phosphoglucan Phosphatases In Regulating Starch Degradation In Plants
… glucan phosphorylation by novel dikinases and phosphatases at the granule surface. This phosphorylation disrupts the semi-crystalline structure of starch, and removal of these phosphates provides access for β- amylases to release maltose. The phosphoglucan phosphatases are members of the dual- …
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Structure and function of the R2B adhesive receptor tyrosine phosphatases
Protein tyrosine phosphatases (PTPs) are key regulators of cellular signalling through the control of cellular phosphotyrosine levels. The R2B family of receptor-like PTPs – PTPRK, PTPRU, PTPRM and PTPRT - are well placed on the plasma membrane at sites of cell-cell contact to influence cell …
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Functional Characterization of Protein Tyrosine Phosphatases in Tumorigenesis through Substrate Identification
<p>Tyrosine phosphorylation plays critical roles in literally every cellular process. Highlighting its importance, the dysregulation of tyrosine phospho-rylation leads to the pathogenesis of many human diseases including cancers. Tyrosine phosphorylation is regulated by two families of enzymes PTKs …
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Regulation of human protein kinases and phosphatases by 14-3-3
… regulates the function of protein kinases and phosphatases in cells.
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Changes in Acid Phosphatases During Differentiation of a Cellular Slime Mold
Made available in DSpace on 2015-05-14T14:57:08Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7121253.PDF: 4012650 bytes, checksum: 5aadbc84755fc44a972eb9ca04299eb6 (MD5) Previous issue date: 1971
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Functional studies on receptor-type protein tyrosine phosphatases of the R3 subgroup
The receptor-type protein tyrosine phosphatases (RPTPs) of the R3subgroup play key roles in the immune, vascular and nervous system. They are characterised by an extracellular domain (ECD), comprised of multiple FNIII-like repeats, a transmembrane domain and a single intracellular phosphatase …
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