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Showing 1 to 3 of 3 for “"Phosphatase of Regenerating Liver"”.
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Investigation of the action of phosphatase of regenerating liver on PTEN using murine models
The addition and removal of phosphate groups is a key regulatory mechanism for many cellular processes. The balance between phosphorylation and dephosphorylation is delicate and must be maintained in order for proper cell functions to be carried out. Protein kinases and phosphatases are the keepers …
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Using High-Resolution NMR to Examine the Components that Contribute to the Activity and Stability of Phosphatase of Regenerating Liver (PRL-1) and Their Dependence on the Redox State of Cysteine Residues
Phosphatase of regenerating liver (PRL-1) has gained attention as an important therapeutic target because of its involvement in cancer and metastasis, where it promotes proliferation and cell motility. The protein is found at high concentration in numerous cancer tissues and when over-expressed …
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The Development of Photo-crosslinkable Trapping Mutants as Tools to Investigate the Interactions of Protein Tyrosine Phosphatases
Abnormalities in the coordinated activities of protein phosphatases (PPs) and<br/>protein kinases (PKs) contribute to the development of many diseases.<br/>Phosphatase of regenerating liver (PRL)-3 and Vaccinia H1-Related (VHR) are<br/>two members of the protein tyrosine phosphatase (PTP) family …