Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Phosphatase and tensin homolog (PTEN)"”.
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The molecular mechanisms of pseudogene-mediated PTEN expression.
The phosphatase and tensin homolog, PTEN, is a protein that negatively regulates the PI3K-Akt pathway through its phosphatase activity. PTEN is a tumour suppressor gene and mutations to the PTEN gene are often a precursor to the development of cancerous cells, common in many different types of …
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The Effects of PTEN Deletion on Cell Size and Plasticity in the Hippocampus
<p>The tumor suppressor phosphatase and tensin homolog (PTEN) is the central negative regulator of the phosphatidylinositol 3-kinase (PI3K) -signaling pathway, which mediates diverse processes in various tissues. In the nervous system, the PI3K pathway modulates proliferation, migration, cellular …
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microRNA-21 as a Pro-Fibrotic Mediator in Right Ventricular Failure
… right ventricle (RV)-specific therapies, and classical pharmacological interventions for LV failure are often not effective when re-appropriated as interventions for RV failure. Different and still largely unknown molecular mechanisms governing the two ventricles, perhaps related to the …
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The Role of IGF-1 and Notch Signaling in Thoracic Malignancies.
… neuroendocrine (small cell lung cancer, or SCLC) and mesothelial origin (malignant mesothelioma, or MM). The DNA oncogenic virus Simian Virus 40 (SV40) has been shown to cooperate with environmental oncogenic fibers in the onset of MM. Insulin like growth factor-1 (IGF-1) signaling plays a central …
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The Effect of Manipulation of the Phosphoinositide 3-kinase Pathway on Axon Regeneration in vivo
… are visually impaired by optic nerve diseases, and glaucoma, the leading cause of irreversible blindness, is due to affect approximately 80 million people by 2020. The optic nerve is comprised of retinal ganglion cell (RGC) axons, and like all mammalian central nervous system axons, they fail to …
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Dual regulation of transcription factor Nrf2 by Keap1 and the beta-TrCP/GSK-3 in cancer
… worldwide with about 14.1 million new incidences and 8.2 cancer related deaths occurring globally. NF-E2 p45-related factor 2 (Nrf2), a cap-‘n’-collar basic leucine zipper (CNC-bZIP) transcription factor, prevents carcinogenesis through expression of genes that ensure the excretion, enzymatic …
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Exploring Cancer Stem Cells (CSCs) pathways to design novel therapies for glioblastoma treatment
… multiforme (GBM) is the most aggressive and common form of primary brain tumor in adults, with a median survival rate of 14 months (Taphoorn et al.;2005 ). GBM is characterized by rapid diffusely infiltrative growth and high level of cellular heterogeneity, which are fueled by …
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The impact of supplemental vitamin D on motor learning and seizures in mice with hyperactive mTOR induced epilepsy and ataxia.
… growth, debilitating motor impairments, and may contribute to the development of epilepsy. mTOR inhibitors can reduce seizures and may prevent behavioral impairments but are associated with serious side effects. Thus, a critical need for better therapies to treat individuals with …