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Showing 1 to 2 of 2 for “"Phosphatase activation"”.
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The intramolecular domain interactions and phosphatase activation mechanisms of Shp2
… Homology 2 Domain-containing Protein Tyrosine Phosphatase 2) is a pivotal player in various signaling pathways in response to growth factors. It contains two SH2 domains (N-SH2 and C-SH2), a phosphatase catalytic domain and a C-terminal tail containing two tyrosyl phosphorylation sites. While …
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The Role of Angiotensin-(1-7) in the Modulation of Angiotensin II-Dependent Cardiac Remodeling
… decreased the Ang II-induced ERK1/ERK2 activation. (0.19 ± 0.11). Previous studies demonstrated that stimulation of MAP kinases is associated with cardiac hypertrophy while over-expression of the MAP kinase phosphatase MKP-1 (the dual-specificity phosphatase, DUSP-1) reduced cardiac …