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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 844 for “"Phosphatase"”.
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The eIF2 phosphatase: characterization and modulation
… ISR is PPP1R15A, a regulatory subunit of Protein Phosphatase 1 (PP1). The PP1/PPP1R15A holophosphatase dephosphorylates eIF2 and terminates the ISR once the stresses are resolved. Hence, eIF2 kinases and phosphatases work together to control levels of phosphorylated eIF2. Maintaining the right …
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Alkaline phosphatase formation in Escherichia coli K10
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Untersuchungen zur Funktion der Protein-Tyrosin-Phosphatase PTPRR
… Somit ist PTPRR die erste tyrosinspezifische Phosphatase, der eine Dephosphorylierung von MAPKn in höheren Eukaryonten nachgewiesen wurde. Eine weitere Analyse durch transiente Überexpression der PTPRR in HEK293-Zellen ergab, daß PTPRR spezifisch die MAPKn ERK1/2, nicht jedoch p38 Kinase oder …
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Spatiotemporal Regulation of the NADP(H) Phosphatase Nocturnin
… with the endonuclease/exonuclease/phosphatase (EEP) domain-containing CCR4 family of deadenylases, we show that highly-purified recombinant NOC lacks ribonuclease activity. Instead, NOC catalyzes the dephosphorylation of NADP(H), and its activity level is associated with the …
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Glucose-6-Phosphatase in Metabolic Disease and Cancer
… recessive IEM caused by defects in Glucose-6-Phosphatase, Catalytic Subunit (G6PC), the terminal enzyme in both glycogenolysis and gluconeogenesis. Fasting hypoglycemia, a prominent symptom of GSD1a, is understandable because of G6PC's role in hepatic glucose output. Other metabolic anomalies …
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Towards the synthesis of novel protein phosphatase inhibitors
Protein phosphatases (PPases) are important enzymes which mediate dephosphorylation of proteins in eukaryotic cells. These enzymes are involved in a variety of cellular processes, and disruption of their activity has been shown to be involved in the development of diseases such as cancers and …
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Studies of T4 Polynucleotide 5'kinase 3'phosphatase
Bacteriophage T4 polynucleotide 5'kinase 3'phosphatase catalyzes two different reactions. Although the biochemical properties of both activities have been relatively well characterized, the role of this enzyme in T4 infection is not understood. By determining the physiological function of this …
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Phosphokinase and Phosphatase Activity of Mammary Gland Homogenates
Made available in DSpace on 2014-12-05T23:07:47Z (GMT). No. of bitstreams: 1 0004425.pdf: 3945838 bytes, checksum: 96e6128c0aeff9ccb0960aad47b6edf5 (MD5) Previous issue date: 1952
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Characterization of the Protein Phosphatase 2A Regulatory Subunit PR70
Protein phosphatase 2A (PP2A) is a phosphoserine/threonine phosphatase that controls the phosphorylation of numerous proteins in eukaryotic cells. PP2A consists of a core dimer composed of a scaffolding subunit (A-subunit) and a catalytic subunit (C-subunit) that interacts with a variety of …
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Cerium oxide Nanoparticles: Their Phosphatase Activity and its Control
… studies have found these nanoparticles possess phosphatase mimetic activity. Studying such catalytic activities will qualify their biomedical applications and render information on their bioavailability and potential toxicity. Two oxidation states of cerium exist in these nanoparticles (3+ or …
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Protein Phosphatase 1 at the Kinetochore Regulates Chromosome Segregation
… kinetochore kinases, including Aurora B. Protein Phosphatase 1 (PP1) plays a counteracting role to Aurora B to stabilize kinetochore-microtubule attachments and silence the SAC. The regulation of PP1 to modulate these functions, however, remains enigmatic. Using the biochemical tools available in …
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Regulation of cell motility by Shp-2 tyrosine phosphatase
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Purification and Characterization of Alkaline Phosphatase of Bacillus Licheniformis
Made available in DSpace on 2014-12-09T22:04:19Z (GMT). No. of bitstreams: 1 6915288.pdf: 5419845 bytes, checksum: 3ab5e3b9047515a55007724d136c42c8 (MD5) Previous issue date: 1969
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Shp2 Regulates Vascular Endothelial Matrix Degradation in Phosphatase-Independent Manner
Shp2 is a protein tyrosine phosphatase that is implicated in many diseases such as developmental disorders and cancers. One of its suggested physiological functions is regulation of angiogenesis, which is often impacted in Shp2 pathologies. However, its role in angiogenesis is still poorly …
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Modulation of Nocturnin Phosphatase Activity through the Disordered Amino Terminus
… to the CCR4 family of endonuclease-exonuclease-phosphatase (EEP) enzymes. Its expression is induced by acute stimuli and loss of Nocturnin (Noct-/-) in mice results in resistance to diet-induced obesity on a high fat diet and confers a protective effect to oxidative stress in HEK cells. Modeling …
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Protein Phosphatase Inhibitor-1 and Cdk5: Of Molecules and Memory
Protein phosphatase inhibitor-1 and cyclin-dependent kinase 5 (Cdk5) have been independently implicated in synaptic plasticity, learning, and memory. We began our studies with the identification, confirmation, and characterization of a novel Cdk5-dependent phosphorylation site (Ser6) on …
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