Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Phorbol esters"”.
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Part-I Characterization of phorbol ester; the predominant toxic component of Jathropha curcas and development of an efficient process for the detoxification of Jathropha curcas meal Part-II quantification of 2-hydroxy-4-(methylthio) butanoic acid and pantothenic acid in bovine serum and sea water matrices
… of jatropha meal and oil is attributed to phorbol esters (PEs), while the major anti-nutritionals are the trypsin inhibitors (TIs). However, chemical characterization of both the jatropha PEs and TIs is at best very sparse. Research described in this dissertation was directed at chemical …
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Diterpenes as models for the study of their effect on neural progenitor cells and on cytochrome p-450 enzymes
… that non-tumor pharmacophores like 12- deoxyphorbols (DPA) and lathyranes with ingol skeleton (ELAC) promote proliferation process in adult neural progenitor cell (NPC) via PKC-activating, thus improving the brain's endogenous neurogenic response to traumatic injury. Occurrence of these …
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Localisation of Protein Kinase C in Apoptosis and Neurite Outgrowth
… cells sensitive to apoptosis induced by phorbol esters or C2-ceramide. Moreover, overexpression of PKCa, PKCd or PKCe sensitises both androgen-dependent and androgen-independent prostate cancer cells to phorbol ester-induced cell-death. The apoptotic effects of PKCd and PKCq in …
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Molecular mechanisms underlying morphological effects of protein kinase C under normal conditions and cellular stress.
… sensitivity to the activators diacylglycerol, phorbol esters and Ca2+. We have previously reported of a neurite-inducing effect specific for PKCε, a novel PKC isoform. The effect has been shown to be mediated through the regulatory domain and independently of the catalytic activity of PKCε. …
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Protein Kinase C as an Apoptosis Regulator and a Potential Prognostic Factor in Breast Cancer
… Smac from the mitochondria. Activation of PKC by phorbol esters rescues the interaction during paclitaxel exposure concomitant with a suppression of cell death. Taken together, we have identified a previously unrecognized interaction and suggest that the PKCδ-Smac association may prevent apoptotic …
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The use of cultured cells with defects of citrulline metabolism in diagnosis and in the study of intercellular communication
… communication. Tumor promoters such as phorbol esters and organochlorine pesticides have been reported to inhibit intercellular junctional communication in other systems, and this inhibitory activity may be related to the mechanism of tumor promotion. The organochlorine pesticide …
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Stimulus-secretion coupling in the exocrine pancreas of the rat: Interactions between secretagogues
… into the effects and mechanisms of action of phorbol esters (and related compounds) on secretagogueevoked 3H-protein release (ACh & CCK8) and pancreatic juice secretion (CCK8 & Secretin) in the rat pancreas. 2. Modifications in extracellular Mg 2 affected ACh-evoked 45Ca2 influx, efflux and …
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Protein phosphorylation and cell diversification in the mouse early embryo.
… two drugs, 6-dimethylaminopurine (DMAP) and a phorbol ester (phorbol myristate acetate, PMA), each of which seems to affect both protein phosphorylation and compaction. DMAP is an adenine analogue and putative inhibitor of protein phosphorylation that was found to perturb the cell cycle of …
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Dynamins and myosin-II regulate the distinct modes of synaptic vesicle exocytosis in mature cerebrocortical nerve terminals and this involves calcium dependent phosphorylations.
… or by supramaximal stimulation of PKC by active phorbol esters leads to a switch in the RRP to a FF mode, it would appear that this site may be important for defining the mode of exocytosis. Activated PKC can also phosphorylate myosin-II but the phosphorylation sites on the myosin-II oligomer …
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ΕΠΙΔΡΑΣΗ ΤΟΥ ΦΟΡΒΟΛΙΚΟΥ ΕΣΤΕΡΑ ΤΡΑ ΣΕ ΑΝΘΡΩΠΙΝΑ ΛΕΥΧΑΙΜΙΚΑ ΛΕΜΦΟΚΥΤΤΑΡΑ
… STUDY WE HAVE INVESTIGATED THE EFFECT OF THE PHORBOL ESTER 12-O-TETRADECANOYLPHORBOL-13-ACETATE (TPA) ON TWO HUMAN LEUKEMIC CELL LINES: 1) THE MOLT3 CELL LINE, WHICH SHOWS TWO PHENOTYPES, THAT OF LARGE THYMIC BLASTS (ABOUT 50% OFTHE CELLS). 2) THE SDK CELL LINE, WHICH INCLUDES CELLS WITH …
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Ενεργοποίηση του ογκογονιδίου ha-ras1 του ανθρώπου από ογκογονίδια ιών και κυττάρων
… THE PROMOTER OF THE H-RAS1 GENE RESPOND TO THE PHORBOL ESTER TPA AND CONTAINS MULTIPLE CONSENSUS SEQUENCES WHICH ARE KNOWN TO BE INDUCED BY TPA OR TO BIND TO THE TRANSCRIPTION FACTOR AP-1. IT IS SUGGESTED THAT PROTEINS OF THE AP-1/NUN FAMILY MAY PLAY A ROLE IN THE CONTROL OF THE HUMAN H-RAS1 …